CJC-1295 With DAC – Product Details
CJC-1295 is a synthetic analog of the growth hormone-releasing hormone (GHRH). GHRH stimulates the anterior pituitary to produce and release growth hormone (GH) into the bloodstream. GH, in turn, stimulates the secretion of insulin-like growth factor (IGF-1) from the liver.
One study has shown that a single administration of CJC-1295 could potentially produce 2- to 10-fold increases in plasma GH concentrations among healthy subjects. Furthermore, multiple CJC-1295 doses resulted in mean IGF-1 levels potentially remaining above baseline for up to 28 days. [R]
PureRawz sells CJC-1295 for laboratory research use only.
|CJC – 1295 DAC Peptide|
|Molar Mass||3367.954 g·mol−1|
|IUPAC Name||CJC 1295 (DAC-GRF)|
What Is CJC-1295 With DAC?
CJC-1295 is a synthetically modified form of GHRH. This peptide hormone potentially stimulates the GHRH to increase the secretion of growth hormones from the pituitary gland. CJC-1295 has also been shown to have the potential ability to increase serum IGF-1 levels in the bloodstream. It may also treat GH deficiency.
CJC-1295 has been proven to have a greater half-life and bioavailability than GHRH. This is due to the addition of drug affinity complex (DAC) to this peptide’s chain. This binding extends CJC-1295’s half-life, potentially resulting in a prolonged duration of action in several animal species. [R]
How Does CJC-1295 Work?
CJC-1295 binds to endogenous albumin and stimulates the release of GH and IGF-1. A single administration of CJC-1295 has been shown to potentially increase mean plasma growth hormone concentrations by 2- to 10-fold and mean plasma IGF-1 concentrations by 1.5- to 3-fold in healthy subjects.
CJC-1295 could take approximately 1-4 hours to reach peak concentrations in the bloodstream. This means it would be slower to act than other growth hormone secretagogues, like Ipamorelin, which may reach peak serum levels more quickly. However, CJC-1295 lasts longer in the bloodstream. [R][R]
That is because this synthetic GHRH analog may selectively and covalently bind to endogenous albumin after administration, thereby extending its half-life as well as the duration of action. [R]
CJC-1295 Vs CJC-1295 With DAC
CJC-1295 is available in two forms, the other containing an added chemical compound known as the drug affinity complex (DAC). Research has shown that the addition of DAC to this synthetic peptide’s chain extends its half-life and duration of action. [R]
This means that CJC-1295 DAC could potentially last much longer in the bloodstream of subjects. It has also been proven that this synthetic peptide has a potentially improved ability than CJC-1295 to bond with blood protein. Pure Rawz sells CJC-1295 with DAC for laboratory and research purposes only.
Multiple clinical trials have been conducted on CJC-1295. This synthetic peptide has also attracted various animal studies. These trials and studies have shown that CJC-1295 could potentially increase GH and IGF-1 levels in the bloodstream and helps subjects overcome GH deficiency.
CJC-1295 and Growth Hormone
A randomized, double-blind placebo-controlled trial was conducted to evaluate the effect of CJC-1295 DAC on GH levels. The study’s participants comprised healthy male and female subjects ages 21 – 61 years. All the subjects had a body mass index of 30 kg/m2 or less.
Results indicated that mean GH concentrations showed the potential to increase by 2- to 10-fold after a single dose administration of CJC-1295. In contrast, mean GH concentrations remained stable in the placebo group. The mean peak GH levels among the CJC-1295 group occurred 0.4 to 5 h after dosing. [R]
CJC-1295 and IGF-1
In the same trial mentioned above, a single dose of CJC-1295 produced potential dose-dependent increases in mean plasma IGF-1 concentrations by 1.5- to 3-fold. Furthermore, one dose had the potential ability to keep the IGF-1 levels elevated for 9-11 days.
Researchers further noted that when multiple CJC-1295 doses were administered to patients, their IGF-1 levels had the potential ability to remain above baseline for 28 days. No more serious adverse reactions were reported, and there were no significant increases in serum cortisol either.
CJC-1295 and GH Deficiency
Although GH replacement therapy has gained widespread acceptance, the need for potential daily administration remains a significant barrier to widespread use. To overcome this limitation, multiple studies are ongoing to potentially try and extend the half-life of the growth hormone-releasing factor. [R]
CJC-1295 was under investigation for the treatment of GH deficiency in adults. Promising results in the earlier stages saw CJC-1295 reach phase II clinical trials, which were discontinued upon the death of one of the trial subjects unrelated to CJC-1295 treatment. [R]
However, an animal study involving GH-deficient mice showed that once-daily administration of CJC-1295 completely normalized growth. Furthermore, at the end of the 5-week treatment period, CJC-1295/24hr group exhibited normal total body weight. [R]
More research is needed to investigate CJC-1295’s effects on GH deficiency.
CJC-1295 and Sleep
Multiple studies have established that GHRH could potentially stimulate sleep, especially non-rapid eye movement (NREM) sleep, which is the first sleep stage you enter after dozing off. Research is currently ongoing to investigate the potential effects of CJC-1295 on sleep. [R]
Where to Buy CJC-1295 With DAC?
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In multiple human studies, CJC-1295 has shown a potential to stimulate insulin-like growth factor 1 and growth hormone release in healthy adults. The increase in GH and IGF-1 levels could be significant and long-lasting.
Higher growth hormone levels have been linked to increased muscle mass. However, GH excess might have a negative impact on bone density.
More research is needed to fully understand the potential effects of this growth hormone secretagogue.