Description

7,8 Dihydroxyflavone – Product Information

• 7,8 Dihydroxyflavone is offered as 1g powder.

What is 7,8 Dihydroxyflavone?

7,8 – Dihydroxyflavone, also referred to as 7,8 -DHF has the chemical formula C15H10O4 and a molecular weight of 254.24g/mol. It is a natural flavone found in Godmania aesculifolia, Tridax procumbens, and primula leaves, it has recently been identified as a promising therapeutic target for BDNF-TrkB signaling. The 7,8-DHF can also reach the brain and exert cognitive effects [R]

7,8-Dihydroxyflavone (7,8-DHF) is a small molecule that is rapidly metabolized in the liver and has a low oral bioavailability. This is due to the extensive first-pass metabolism of 7,8-DHF, which reduces the amount of the substance that reaches the systemic circulation.

7.8 Dihydroxyflavone
CAS Number	38183-03-8
Molar Mass	254.241 g·mol−1
Chemical Structure	C15H10O4
IUPAC Name	7,8-Dihydroxy-2-phenyl-4H-chromen-4-one

How Does 7,8 Dihydroxyflavone Work?

7,8-Dihydroxyflavone (7,8-DHF) has the potential ability to cross the blood-brain barrier. It effectively mimics the effect of brain-derived neurotrophic factor (BDNF) in the brain by selectively activating tyrosine kinase receptor B (trkb receptors) and downstream signaling pathways, giving neuroprotective effects (or neurogenerative effects occur in neurons). [R] It also helps restore communication between neurons in animal models.

It has been studied for its potential health benefits and is used as an ingredient in dietary supplements. While there is still much to learn about the effects of 7,8 Dihydroxyflavone on human health, it has been studied for its potential to help with a variety of suspected medical conditions including cancer, Alzheimer’s disease, depression, and obesity.

7,8-Dihydroxyflavone (7,8-DHF) is a small molecule that is rapidly metabolized in the liver and has a low oral bioavailability. This is due to the extensive first-pass metabolism of 7,8-DHF, which reduces the amount of the substance that reaches systemic circulation.

7,8 Dihydroxyflavone  Research

Numerous animal models and human studies have been conducted on the potential application of 7,8 Dihydroxyflavone. Below follows some of the relevant findings:

7,8 Dihydroxyflavone on Neurodevelopmental Disorders

Neurodevelopmental disorders are a group of conditions caused by central nervous system impairments during development. Brain-derived neurotrophic factor (BDNF) is a fundamental neurotrophin that plays an important role in brain development.

Pre-clinical research indicates that increasing BDNF signaling may be an effective way to prevent, arrest, or even reverse abnormal neurodevelopmental events caused by a variety of genetic or environmental factors.

However, many difficulties make administering BDNF efficiently difficult. The recent discovery of a small BDNF-mimetic, the naturally occurring flavonoid 7,8-dihydroxyflavone (7,8-DHF), may open the door to efficient and safe activation of the BDNF pathway in treating neurodevelopmental disorders.[R]

7,8 Dihydroxyflavone on neuroprotective effects Parkinson’s disease

Parkinson’s disease (PD) is a common neurodegenerative disease characterized by a significant loss of dopaminergic neurons in the midbrain.

A study was conducted to understand the effect of DHF on monkey models with Parkinson’s disease. It was discovered that 7, 8-DHF could be absorbed and metabolized into 7-hydroxy-8-methoxyflavone in monkeys after oral administration. In monkey plasma, the half-life of 7, 8-DHF is 4-8 hours.

Furthermore, these monkeys remain healthy after seven months of treatment with 7, 8-DHF (30 mg/kg/day). Importantly, 7, 8-DHF treatments have been shown in monkeys to prevent the progressive degeneration of midbrain dopaminergic neurons by attenuating the neurotoxic effects of MPP+. The findings showed the promising small molecule can be developed into a clinically useful pharmacological agent. [R]

While some of these health benefits have been demonstrated in monkeys, more research is needed to determine the effects of 7,8 dihydroxyflavone on human cognitive effects.

7,8 Dihydroxyflavone on Improved Memory and Learning

Brain-derived neurotrophic factor (BDNF) is a key regulator of how neurons in the central nervous system live and change (CNS). Because of this, there has been a growing interest in the role of BDNF in neuropsychiatric disorders like depression and dementia that are linked to neurodegeneration.

The effect of 7,8-DHF on the processes involved in the consolidation of memories was investigated in the current study. When given to healthy rats and used in an object recognition task, 7,8-DHF improved memory consolidation processes in rats and mice. of previously learned objects in the context of the task. This effect was seen both immediately and 3 hours after learning.

Potent antidepressant effects are evident when BDNF/TrkB-signaling has enhanced via the administration of 7,8-DHF [this study suggests that 7,8-DHF might be a promising therapeutic target for dementia]. According to the findings of this study, 7,8-DHF has the potential to be a useful therapeutic target for dementia.[R]

It’s important to note that while some of these health benefits have been shown in mice subject to cognitive function, further research is needed to determine if the effects are similar in humans’ brain health.

7,8 Dihydroxyflavone on Reduced Anxiety and Depression

In a study, 7,8-DHF reversed the partially anxious and depressive-like behaviors brought on by Chronic Mild Stress (CMS). It showed that the CMS-subjected rats’ hippocampal BDNF levels and serum corticosterone levels were both significantly increased by 7,8-DHF, which may account for the medication’s antidepressant and/or partial anxiolytic effects. The study offers a novel therapeutic approach to depression: a TrkB agonist, 7,8-DHF. It possesses a fast-onset antidepressant effect and a partial anxiolytic effect.

Most importantly, chronic systemic treatment with this drug has the benefit of being more feasible and less invasive than viral or recombinant protein delivery and allows the chronic targeting of neural pathologies of depression where BDNF levels and HPA axis activity are dysregulated. [R]

Other studies have found that 7,8 Dihydroxyflavone can increase the number of neurotransmitters released by other neurons, leading to improved communication between them and an antidepressant effect.

It’s important to note that while some of these health benefits have been shown in mice, further review research is needed to determine the effects of 7,8 dihydroxyflavone in humans. Always consult with a qualified health physician before taking any new dietary supplement or other supplement to treat cure or prevent such disease.

7,8 Dihydroxyflavone on Cardioprotective Effects

Cardiac fibrosis is defined by an abnormal accumulation of collagens and other ECM proteins in the cardiac interstitial space.

The purpose of the study was to look into the effects of 7,8-DHF on cardiac fibrosis and the possible mechanisms. Treatment with 7,8-DHF significantly reduced cardiac fibrosis in mice with Myocardial Ischemia (MI).7,8-DHF reduces cardiac fibrosis and, at least partially, regulates circadian rhythmic signals by inhibiting the Bmal1/Akt pathway, which may provide new insights into therapeutic cardiac remodeling.

By inhibiting the Bmal1/Akt pathway, 7,8-DHF reduces cardiac fibrosis and, at least partially, regulates circadian rhythmic signals, potentially providing new insights into therapeutic cardiac remodeling. [R]

However, it should not be used to diagnose or treat any medical condition without consulting with a doctor first. The potential side effects of 7,8 Dihydroxyflavone are still being studied and more research needs to be done before it can be recommended for use.

7,8 Dihydroxyflavone on Anti-inflammatory Effects

The cellular and molecular mechanisms of 7,8-DHFs as anti-inflammatory were studied in cell culture. The findings suggest that the anti-inflammatory property of 7,8-DHF is related to the downregulation of iNOS, COX-2, and IL-1 in RAW264.7 cells as a result of NF-B inhibition, as well as the negative regulation of MAPK activation. As a result, 7,8-DHF could be a novel therapeutic agent for the prevention of a variety of inflammatory diseases.[R]

More research is needed to fully understand the mechanisms of action and potential therapeutic applications of 7,8-DHF in order to fully realize its anti-inflammatory effects. In addition, taking 7,8-DHF as a food dietary supplement has not been thoroughly studied for its safety or long-term effects.

7,8-DHF against Alcohol and High-Fat Diet (HFD)

A  study was conducted to determine the protective effect and molecular mechanism of 7,8-DHF in rats against alcohol and high-fat diet (HFD)-induced memory deficits. It was found that 7,8-DHF administration in rats improved memory deficits caused by alcohol and HFDs due to its unique antioxidant, anti-inflammatory, and anti-apoptotic properties, as well as activation of the TrkB/BDNF signaling pathway in the hippocampus.[R]

However, it should not be used to diagnose treat cure any medical conditions since 7,8 Dihydroxyflavone’s side effects must be evaluated more before intended use.

7,8 Dihydroxyflavone on Obesity

Chronic activation of the brain-derived neurotrophic factor TrkB receptor is a potential method for preventing the development of obesity, but the short half-life and non-bioavailability of BDNF make validation difficult. The activation of muscular TrkB by the BDNF mimic 7,8-dihydroxyflavone is sufficient to protect female mice from diet-induced obesity.[R]

However, more research is needed to fully understand the effects of 7,8-DHF on obesity and related health conditions.

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