PAL-GHK (10mg Powder) – Product Details

PAL-GHK, otherwise known as glycyl l histidyl lysine, is a peptide split from the human endogenous tetrapeptide GHK. PAL-GHK (Palmitoyl oligopeptide and palmitoyl tetrapeptide-3) is a peptide complex that has been extensively studied for its collagen-stimulating properties.

PAL-GHK, sometimes known as Pro-Vitamin A, is a cell-regenerating nutrient. Research has established that PAL-GHK plays an important role in improving the skin’s ability to cope with acne, wrinkles, stretch marks and scarring [R].

PAL-GHK offers other benefits such as improving the overall texture and hydration of the skin. It works by stimulating the natural production of collagen and elastin which are responsible for skin health and elasticity [R]. PAL-GHK is increasingly being featured in anti wrinkle creams on the market today, as the anti aging effects that it offers can help reduce wrinkles and lines caused by aging and sun damage.

What is PAL-GHK?

PAL-GHK, or palmitoyl tripeptide-1, is a palmitic acid-based peptide molecule that has been proven to have anti-aging effects on human skin fibroblasts. It works by upregulating the extracellular matrix (ECM) proteins of dermal cells, producing collagen and increasing the overall elasticity of the skin [R]. This makes it an ideal agent for improving the natural ageing process, as PAL-GHK’s acid chains interact with lipids found in the stratum corneum to aid in moisture retention and reduce the appearance of wrinkles.

PAL-GHK reduces collagen degradation and is therefore gaining recognition in the cosmetics industry as an effective ingredient with scientifically supported results in assisting towards youthful looking skin [R]. PAL-GHK also shows potential to be used as an internal standard in biophysical chemical analysis.

How Does PAL-GHK Work?

PAL-GHK (PGH) is an adhesion molecule that participates in the adhesion of calcium phosphate crystals. It has been the subject of intensive research to characterize its role in the mineralization process. PGH plays a key role in adhesion processes, promoting adhesiveness and stability of crystallized structures. These adhesion molecules also participate in inflammatory reactions and wound healing by binding integrin molecules.

The most well-recognised function of Palmitoyl peptide is that it increases collagen synthesis and helps to promote collagen production within the dermal layers of skin, ultimately promoting a more youthful complexion [R].

PGH is especially effective at helping to repair collagen damage that naturally occurs due to environmental stressors like aging, exposure to ultraviolet (UVA light) radiation and other pollutants. Palmitoyl tripeptide 1 helps cells hold onto collagen molecules more effectively, which aids in collagen formation and keeps the skin firmer and hydrated while reducing wrinkles and other visible signs of aging [R].

Potential Research Benefits

When applied topically, PAL-GHK has the potential to stimulate the skin’s natural collagen and elastin production, resulting in smoother skin [R]. It has also been shown to reduce wrinkles, redness and dark spots while maintaining or increasing hydration levels. In addition, it may help protect against environmental stressors like UV radiation, making it ideal for daily use alongside sunscreen as part of an overall sun protection regimen [R]. Furthermore, it may help improve wound healing after certain procedures such as microdermabrasion and laser therapy [R].

Collagen Degradation Ex Vivo

Studies have shown that this collagen degradation ex vivo has the potential to improve collagen hydration and density. This has several beneficial effects on overall skin health, including relief from inflammation, wrinkle softening, improved elasticity and texture, as well as improving collagen and elastin production [R].

Other studies suggest that Palmitoyl tripeptide 1 may help to protect against collagen loss due to external forces, such as smoking and air pollution. Consequently, it can provide vital support for collagen maintenance and renewal for healthy skin cells and ultimately lead to an overall healthier complexion with improved tone and texture [R].

Dermal Skin Layers

Dermal skin layers are made up of proteins such as collagen and elastin, which degrade with age leading to wrinkles and dryness [R]. Studies have shown that when applied topically, Palmitoyl tripeptide 1 works by stimulating the synthesis of new collagen and elastin in the skin leading to improved hydration [R].

In addition, it increases the activity of antioxidants responsible for promoting a healthy epidermis. The result is smoother, firmer looking skin with fewer wrinkles and a healthier glow [R].

Wound Healing

It is believed that the peptides accelerate the process of skin repair by evoking an inflammatory response, increasing epidermal growth factors, enhancing collagen production and improving tissue defense [R].

Wound healing is a complex process requiring precise interactions between cell-derived factors and extracellular matrix components. Studies demonstrate that PGH greatly improves wound healing by activating both biochemical and cellular cascades which facilitate a rapid recovery from wounds [R].

Summary of PAL-GHK

PAL-GHK is a peptide derived from palmitoyl-lysine-glycine-histidine-lysine that has been shown to be advantageous for skin care [R]. Studies on PAL-GHK’s effect on the stratum corneum, revealed that PAL-GHK helps increase collagen synthesis as well as providing great moisturisation and further barrier protection [R].

PAL-GHK consists of palmitic acid, lysine, glycine and histidine residues in a specific order that allows it to self assemble into a more efficient form without additional components.

As PAL-GHK infiltrates the stratum corneum, it nourishes the skin through the metal-ion dependent structure that aids in both increasing collagen production and enhancing barrier restoration abilities. Subsequent studies have continued to explore PAL-GHK’s mechanism of action within the study of its self assembly process as well as its beneficial results for skin health.