PAL-GHK

Description

Pal-GHK Overview

Pal-GHK is a synthetic peptide analog. It is derived from the naturally occurring tripeptide GHK and chemically modified with a palmitoyl group. Palmitoylation is commonly used in peptide engineering. 

The addition of a palmitoyl group has been associated with increased molecular stability and lipid affinity in peptide research. The peptide has been studied for its interactions within lipid-rich environments and membrane-associated research models.

Chemical Properties

Formal Name	N-(1-oxohexadecyl)glycyl-L-histidyl-L-lysine
CAS Number	147732-56-7
Synonyms	C16-GHK C16-GK-3 Palmitoyl Oligopeptide Palmitoyl Tripeptide-1
Molecular Formula	C30H54N6O5
Formula Weight	578.8
Purity	Purity ≥95% (verified by HPLC or equivalent analytical method)
Solubility	DMF: 30 mg/ml DMSO: 10 mg/ml Ethanol: 30 mg/ml
InChi Key	BYUQATUKPXLFLZ-UIOOFZCWSA-N
λmax	283 nm
Storage	-20°C
InChi Code	InChI=1S/C30H54N6O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-27(37)33-22-28(38)35-26(20-24-21-32-23-34-24)29(39)36-25(30(40)41)17-15-16-19-31/h21,23,25-26H,2-20,22,31H2,1H3,(H,32,34)(H,33,37)(H,35,38)(H,36,39)(H,40,41)/t25-,26-/m0/s1

What is the Proposed Working Mechanism of Pal-GHK?

Pal-GHK is investigated in experimental models as a peptide analog of GHK. In cellular research, preclinical models, peptide signaling molecules are studied for their interactions with receptor-mediated pathways. These pathways have been associated with regulation of extracellular matrix–related protein expression and cellular communication in in vitro studies. 

The palmitoyl modification increases the peptide's lipophilic properties. Palmitoyl modification has been studied for its potential to influence how the molecule associates with lipid membranes in experimental systems. 

These interactions have been studied to evaluate peptide transport, molecular stability, and diffusion behavior in experimental environments.

Additionally, synthetic peptide derivatives such as Pal-GHK are often evaluated in structure-activity relationship (SAR) investigations. 

Possible Research Applications of Pal-GHK

Within controlled laboratory environments, Pal-GHK may be utilized for investigations involving:

• Peptide signaling pathway analysis in experimental models
• Extracellular matrix-related protein expression studies
• Peptide stability and lipid-associated transport investigations
• Structure-activity relationship studies involving synthetic peptide analogs
• Molecular evaluation of peptide components used in cosmetic research systems

All applications are limited strictly to analytical and experimental research environments.

Why Choose Purerawz?

Buy Pal-GHK for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each compound is supplied with an independent third-party Certificate of Analysis verifying identity, purity, and concentration.

Note: Pal-GHK is an investigational peptide currently undergoing scientific evaluation and has not been established as safe or effective for any therapeutic application.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH PURPOSES ONLY.

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ATTENTION: All products are for LABORATORY AND RESEARCH PURPOSES ONLY. They are not for veterinary or human use.

Reference Links

• Copper peptide GHK: biological activity and molecular signaling roles - Journal of Biomolecular Structure and Dynamics https://doi.org/10.1080/07391102.2020.1744425/
• Palmitoylated peptides and lipid-mediated cellular interactions - International Journal of Molecular Sciences https://doi.org/10.3390/ijms21010242/
• Pal-GHK (CAS 147732-56-7). (2026). Caymanchem.com; Cayman. https://www.caymanchem.com/product/27059/pal-ghk?srsltid=AfmBOoqivM6D-6Dq59maIelddSV4AnZFVTxY4ai5LgIvrrPjzG84mw9v