FGL

Description

Overview

FGL peptide is a synthetic 15–amino acid peptide fragment derived from a functional region associated with Fibroblast Growth Factor-2 (FGF-2) signaling. The peptide corresponds to a sequence that mimics the FG loop region of the Neural Cell Adhesion Molecule (NCAM), a protein involved in cellular communication within neural tissues.

Because of this structural relationship, FGL is frequently studied in investigational neuroscience research to explore mechanisms related to receptor-mediated signaling and neuronal communication.

In in vitro studies and experimental research models, FGL is used to investigate how NCAM-associated peptide fragments interact with fibroblast growth factor receptors (FGFRs) and influence intracellular signaling pathways. These molecular interactions are of interest in laboratory environments examining synaptic signaling networks, receptor activation mechanisms, and intracellular signal transduction processes.

Chemical and Molecular Properties

Compound Name	FGL Peptide
Synonyms	FGL peptide; HY-P3281; DA-53184
CAS Number	499993-62-3
PubChem CID	16200289
Molecular Formula	C₇₁H₁₁₆N₂₀O₂₅
Molecular Weight	1649.8 g/mol
Chemical Classification	Synthetic peptide
Amino Acid Length	15 amino acids
IUPAC Name	L-alpha-glutamyl-L-valyl-L-tyrosyl-L-valyl-L-valyl-L-alanyl-L-alpha-glutamyl-L-asparagyl-L-glutaminyl-L-glutaminyl-glycyl-L-lysyl-L-seryl-L-lysyl-L-alanine
Physical Form	Typically supplied as a lyophilized peptide powder for research applications
Chemical Structure Description

Working Mechanism

FGL peptide is investigated in experimental neuroscience models for its ability to mimic a functional interaction region associated with NCAM-FGFR signaling. The mechanism examined in laboratory studies primarily involves receptor activation and intracellular signal transduction pathways.

• FGL contains a sequence designed to replicate a region of NCAM responsible for interaction with fibroblast growth factor receptor-1 (FGFR1).
• When studied in experimental cell systems, FGL can bind to FGFR1, a receptor tyrosine kinase associated with multiple intracellular signaling cascades.
• Through receptor-mediated signaling activation, FGL is investigated as a research tool for studying intracellular pathways involved in neuronal signaling processes, synaptic communication mechanisms, and receptor-driven transcriptional responses within controlled experimental systems.

Experimental studies have shown that FGFR1 activation can trigger several intracellular pathways frequently examined in cell signaling research, including:

• MAPK/ERK signaling pathway, involved in cellular signal transduction and transcriptional regulation 
• PI3K–Akt signaling pathway, associated with intracellular regulatory signaling networks 
• PLCγ pathway, which contributes to intracellular calcium signaling dynamics

Research Applications of FGL Peptide in Laboratory Settings

NCAM–FGFR Signaling Studies

FGL is utilized in in vitro receptor interaction studies to investigate how NCAM-derived peptide sequences influence FGFR activation and downstream signaling pathways.

Synaptic Signaling and Cellular Communication Research

Researchers employ FGL in experimental neural cell models to study intracellular signaling pathways that regulate neuronal communication and synaptic signaling dynamics.

Intracellular Signal Transduction Analysis

FGL can be used in molecular pathway experiments designed to analyze activation of signaling cascades such as MAPK/ERK, PI3K–Akt, and PLCγ in controlled experimental systems.

Neurobiology and Cellular Signaling Investigations

In preclinical research environments, FGL may serve as a peptide-based research tool for examining molecular pathways involved in neuronal signaling networks and receptor-mediated communication.

Experimental Models of Neural Signaling Pathways

FGL is also used in laboratory-based neurobiological studies that investigate how peptide fragments influence intracellular regulatory pathways related to neural cell signaling processes.

Why Choose Purerawz for FGL Peptide?

Buy FGL Peptide for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

Reference Links

• Anand, R., Seiberling, M., Kamtchoua, T., & Pokorny, R. (2007). Tolerability, safety and pharmacokinetics of the FGLL peptide, a novel mimetic of neural cell adhesion molecule, following intranasal administration in healthy volunteers. Clinical Pharmacokinetics, 46(4), 351–358. https://doi.org/10.2165/00003088-200746040-00007
• Popov, V. I., Medvedev, N. I., Kraev, I. V., Gabbott, P. L., Davies, H. A., Lynch, M., Cowley, T. R., Berezin, V., Bock, E., & Stewart, M. G. (2008). A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three–dimensional ultrastructural study. European Journal of Neuroscience, 27(2), 301–314. https://doi.org/10.1111/j.1460-9568.2007.06004.x