IGF-1 DES – Product Information
For research purposes, it is recommended to reconstitute this compound with Acetic Acid 0.6%. The addition of acetic acid to the IGF solution plays a vital role in preserving its activity by maintaining pH balance and stability. Furthermore, acetic acid assists in ensuring proper dispersion and enhancing the solubility of the IGF compound, preventing degradation.
IGF-I DES belongs to the insulin gene family and has been isolated from the bovine colostrum, human brain, and porcine uterus. It is a truncated variant of a vital growth hormone known as IGF-I with the tripeptide Gly-Pro-Glu missing from the N-terminus. [R]
This protein is most likely the result of IGF-I post-translational cleavage. IGF-1 DES is approximately ten times more potent than IGF-I in stimulating hypertrophy and proliferation of cultured cells. [R] In vitro studies demonstrate that IGF-1 DES has potential medical applications, but the chemical still needs more clinical trials to confirm its benefits.
Purerawz sells IGF-1 DES for research purposes only.
|Molar Mass||1546.9 g/mol|
What is IGF-1 DES?
IGF-1 DES, also known as insulin growth factor DES, is a truncated version of IGF-1 in which it lacks the first three amino acids at the N-terminus of IGF-1. It is a naturally occurring variant of IGF-1 that has been found in the human brain, cow colostrum, and pig uterine tissue. [R]
It is ten times more potent than IGF-1 in stimulating cell hypertrophy and proliferation because it is unaffected by IGF-1 binding proteins and thus, more bioavailable. [R] From here, we could say that it could also provide specific effects that IGF-1 gives, including certain growth-promoting effects affecting muscle growth.
Interest is shown in using the peptide to induce anabolism in catabolic conditions and to treat inflammatory bowel disease. [R]
It is considered a research chemical, which implies utilizing the drug for laboratory and research use only. The experimental chemical is not advised for human consumption.
You may use this post as your own review of IGF-1 DES to determine its potential applications and uses.
How does IGF-1 DES Work?
IGF-1 DES is a shortened form of the standard IGF-1 having a tri-peptide structure. It has been intentionally separated to be more effective in specific tissue types.
It is ten times more effective than IGF-1 in the hypertrophy and proliferation of so-called satellite cells in muscle tissue and other tissues due to the changed structure. Furthermore, it should have a significantly greater metabolic and fat-burning effect than standard IGF-1. [R]
Additionally, it can preserve several functions of IGF-1, such as enhancement of skeletal muscle growth and neuron protection. However, the former differs from the latter because it does not bind to IGFBPs. This feature enables IGF-1 DES to be more useful. For one, it allows the peptide to pass into the brain quicker than its counterpart.
IGF-1 DES vs IGF-1 LR3
IGF-1 DES and IGF-1 LR3 are two different forms of insulin-like growth factor 1 (IGF-1), each with distinct characteristics and mechanisms of action. Here are the key differences between IGF-1 DES and IGF-1 LR3:
IGF-1 DES is a shortened form of IGF-1 that consists of the first three amino acids of the IGF-1 sequence (des(1-3)). It has a shorter half-life compared to the full-length IGF-1 and lacks the C-terminal extension found in IGF-1 LR3.
IGF-1 LR3 is a modified form of IGF-1 that has a longer half-life than the native IGF-1. It contains a modified amino acid sequence with the substitution of arginine for glutamic acid at position 3 (hence “Long R3”). This modification allows for increased stability and a prolonged duration of action.
Both IGF-1 DES and IGF-1 LR3 are believed to exert their effects by binding to the IGF-1 receptor (IGF-1R). Activation of the IGF-1R signaling pathway plays a crucial role in various cellular processes, including cell growth, proliferation, and differentiation. However, due to their structural differences, IGF-1 DES and IGF-1 LR3 may have varying affinities for the IGF-1R and interact differently with other binding proteins.
What are the Potential Applications of Insulin Growth Factor (IGF-1) DES?
IGF-1 DES and Neurological Disorders
The experimental compound being considered could also provide specific cognitive benefits that could influence cognitive function among mammals.
IGF-1 and its analogs were tested for Rett syndrome and chromosome 22 deletion syndrome. The peptides had a good effect in these circumstances. Aside from preserving excitatory synapses in the brain and increasing neuron density, IGF-1 reduced the harmful effects of NMDA over-stimulation. This property shielded neurons against excitotoxicity, which could result in neuron death. [R]
IGF-1 DES and Autism Spectrum Disorder
Using a mouse model that expresses most of the critical core as well as associated behavioral deficits of ASD, namely social, cognitive, and repetitive behaviors, we show that systemic administration of the polypeptide insulin-like growth factor II (IGF-II) reverses all of these deficits. [R]
The effects of IGF-II are mediated by IGF-II receptors rather than IGF-I receptors, and they target both basal and learning-dependent molecular abnormalities found in several ASD mouse models, including those caused by identified genetic mutations. [R]
We believe that IGF-II could be a new therapeutic target for ASD. [R]
IGF-1 DES and Immune Function
Many immune system cells, such as mononuclear cells and neutrophils, have IGF-1 receptors on their surface. According to research, it can improve immune function by increasing the release of hydrogen peroxide in mononuclear cells and encouraging neutrophils to differentiate into pathogen-killing blastocytes. [R]
IGF-1 DES and Cancer
One of the issues with cancer cells is that they are undifferentiated at an early stage of differentiation. This causes the cells to malfunction. [R]
Cells in the later stages of differentiation grow at a slower rate. Forced differentiation of cancer cells may slow tumor growth. It has been shown from in vitro studies to force certain cancer cells to differentiate, slowing tumor growth by inhibiting differentiation. [R]
IGF-1 DES 1 DES and Wound Healing
Dermal fibroblasts are the primary cells responsible for tissue repair following injury. Under certain conditions, these cells produce several IGFBPs, and it is well known that this protein significantly reduces the impact of IGF-1 on its other receptors. [R]
According to research, inflammatory cytokines can alter IGFBP levels, which may impact healing. It is possible to avoid the effects of inflammatory cytokines by administering peptides unaffected by IGFBP. [R]
This, in turn, has the potential to accelerate wound healing. [R]
Safety and Side Effects
It does come with side effects, as supported by empirical evidence from the compound’s studies. Here are the known possible adverse research reactions of IGF-1 DES in research subjects:
- Temporary subcutaneous water retention
- Joint pain
Frequently Asked Questions
How is IGF-1 DES different from IGF-1?
It lacks three amino acids which are present in IGF-1. Such a small change, however, makes the experimental compound more potent. Animal studies show that IGF-1 DES is more effective in lowering blood sugar than IGF-1. [R]
Can IGF-1 DES promote muscle growth in research subjects?
It has also been demonstrated that IGF-1 DES has one to three times the effects on tissue growth, particularly muscle tissue, compared to IGF-1. [R]
Where can you buy IGF-1 DES?
PureRawz is the best place to buy IGF-1 DES online for your laboratory research. We offer other high-quality peptides you could use for your clinical research studies.
In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
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