Mazdutide

Description

Mazdutide Overview

Mazdutide, also known as IBI-362, is a synthetic dual-receptor agonist peptide studied in preclinical and laboratory research models. It is designed to activate two primary receptors:

• GLP-1 receptor (GLP-1R)
• Glucagon receptor (GCGR)

Mazdutide is an acylated peptide analogue with structural modifications intended to enhance stability and prolong its half-life in experimental settings. Researchers investigate Mazdutide to understand receptor activity and downstream cellular signaling in metabolic research models.

Chemical and Molecular Properties

PubChem CID	167312357
Molecular Formula	C207H317N45O65
Molecular Weight	4476 g/mol
Synonyms	IBI362 2259884-03-0 GTPL13924 IBI-362
IUPAC	20-[[(1S)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-5-amino-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-2-methylpropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[2-[(2S)-2-[[(2S)-1-[(2-amino-2-oxoethyl)amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-2-oxoethyl]amino]-2-oxoethyl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-20-oxoicosanoic acid
CAS	2259884-03-0
Labeling	Research Use Only (RUO), not for human or animal consumption
Chemical Structure Depiction
Purity	>95%
Classification	Research Use Only (RUO)
Storage Temperature	Store at -20°C (-4°F) for long-term stability
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Mechanisms of Action

Mazdutide functions as a dual-receptor peptide agonist in controlled laboratory studies. Its primary actions are observed through:

GLP-1 Receptor (GLP-1R) Activation

• Studied for effects on glucose-dependent cellular signaling in experimental models
• Explored for modulation of nutrient absorption and energy-processing pathways in preclinical research

Glucagon Receptor (GCGR) Activation

• Investigated for its influence on cellular energy regulation and metabolic signaling
• Studied for coordinated receptor signaling networks in laboratory models

Potential Research Applications

Mazdutide is used in preclinical and laboratory research to study:

• Receptor activation profiles: GLP-1R and GCGR signaling in experimental models
• Intracellular signaling pathways: Mapping downstream pathways in controlled research systems
• Metabolic pathway studies: Examining cellular energy regulation, glucose-dependent pathways, and receptor-mediated signaling networks
• Preclinical model studies: Investigating potential interactions with cellular metabolic and endocrine pathways

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

References:

1. Nalisa, D. L., Cuboia, N., Dyab, E., Jackson, I. L., Felix, H. J., Shoki, P., Mubiana, M., Oyedeji-Amusa, M., Azevedo, L., & Jiang, H. (2024). Efficacy and safety of Mazdutide on weight loss among diabetic and non-diabetic patients: a systematic review and meta-analysis of randomized controlled trials. Frontiers in Endocrinology, 15, 1309118. https://doi.org/10.3389/fendo.2024.1309118
2. Guo, L., Zhang, B., Xue, X., Zhang, X., Cai, H., Jiang, H., Zhang, L., Jin, P., Wang, X., Cheng, Z., Zhang, S., Geng, J., Guo, Y., Hu, H., Ma, Q., Li, L., Du, H., Han-Zhang, H., Xue, F., . . . Investigators, O. B. O. T. D. (2025). Mazdutide versus dulaglutide in Chinese adults with type 2 diabetes. Nature. https://doi.org/10.1038/s41586-025-10031-z