What is TUDCA?

TUDCA is a water-soluble bile acid that has been used in traditional Chinese medicine for centuries due to its therapeutic potential. As one of 8 bile acids in the body, it has been shown to improve insulin sensitivity and cholesterol in clinical populations. [R][R][R]

TUDCA is formed through a microbial process in the body. The process kicks off with the production of ursodeoxycholic acid or UDCA (another bile acid) in the lower intestine. UDCA then gets conjugated to a molecule of Taurine (an amino acid) to produce TUDCA.

In various clinical trials, it has exhibited the ability to improve overall liver health. TUDCA treatment has been associated with improved liver function in patients with hepatitis, liver cirrhosis, and cholestasis. It may also reduce markers of liver inflammation. [R][R][R]

How does TUDCA Work?

Although its exact working mechanism remains unknown, TUDCA has been shown to:

• Boost insulin sensitivity to help your body use glucose more effectively [R]
• Prevent programmed death of body cells (apoptosis) by various mechanisms [R]
• Help proteins fold properly by relieving endoplasmic reticulum stress [R]
• Remove toxic bile acids from your liver and keep them from damaging liver cells [R]

Research Applications

What follows is a summary of the existing research on TUDCA. The information presented in this section is for educational purposes only and doesn’t constitute medical advice. PureRawz sells gluten-free and soy-free TUDCA for laboratory and research purposes only.

1) Cholestasis

Cholestasis is a disease in which the healthy flow of bile acids from your liver is impeded. It can be a life-threatening condition in pregnant females. Symptoms of this condition include excessive itching, jaundice, light-colored stool, and pain in the abdomen area. [R]

In a randomized, double-blind trial, 76% of patients in the TUDCA group experienced a serum ALP reduction of more than 25% from baseline after just one week of treatment. The results are significant because cholestasis is characterized by increased serum ALP levels. [R][R]

2) Hepatitis C

Hepatitis C is one of the most common liver disorders worldwide, causing about 1.5 million new infections each year. Among other symptoms, patients with this condition generally have elevated aminotransferase serum (ALT) levels in their bloodstream. [R]

According to a multi-center, placebo-controlled study, TUDCA treatment (500 mg/day or 700 mg/day) produced a consistent decrease in aminotransferase serum levels (ALT) in patients with the hepatitis C virus. A progressive improvement in patients’ condition was also found. [R]

3) ALS

Amyotrophic lateral sclerosis is a rare neurological disease that is almost always fatal. Patients with this condition have a remaining life expectancy of only five years. [R]

In a double-blind, placebo-controlled study, 34 patients were administered TUDCA (1g twice daily) or a placebo dietary supplement for 3 months. Following a year of treatment, the TUDCA group experienced improved ALSFRS-R levels and consequently less disability with ALS. [R]

4) Liver Cirrhosis

Liver cirrhosis, or scarring of the liver, is an incurable disease. It affects 1 in every 400 adults in the US and causes more than 0.8 million deaths every year. [R]

In a double-blind, placebo-controlled trial, TUDCA treatment improved the outcome measure in 23 patients with liver cirrhosis.

The authors concluded that TUDCA therapy is safe and more effective than FDA-approved dietary supplements in the treatment of liver cirrhosis. [R]

5) Insulin Sensitivity

Insulin sensitivity is a measure of how sensitive the body is to insulin. Low insulin sensitivity leads to elevated blood glucose levels and may, over time, lead to pre-diabetes and type-2 diabetes. [R]

According to a trial involving 20 obese men and women with insulin resistance, TUDCA treatment (1,750 mg/day for 4 weeks) caused a 30% increase in insulin sensitivity in the liver and muscle. It remains unknown whether this bile salt could replicate the effects in adults without insulin resistance. [R]

6) Cholesterol

High cholesterol levels raise your risk of developing life-threatening conditions, such as stroke, high blood pressure, angina, and heart attack. [R]

In a small study involving 24 cirrhosis patients, higher doses of TUDCA (1,000 or 1,500 mg/day) for 6 months decreased total control compared to baseline. However, TUDCA treatment also reduced high-density lipoprotein (aka ‘good’) cholesterol levels. [R]

7) Alzheimer’s

In multiple pre-clinical studies, TUDCA has shown great therapeutic potential for the treatment of Alzheimer’s disease (AD). [R]

Various studies performed in 2003 reported that TUDCA inhibited AB-induced apoptosis (death) in the primary culture of rat cortical neurons. Considering the role of apoptosis in AB-induced toxicity, TUDCA may delay the neurodegenerative process in individuals with AD. [R]

Frequently Asked Questions

Is TUDCA legal?

In Europe, various TUDCA supplements have been approved to treat amyotrophic lateral sclerosis (ALS). In the US, TUDCA is clinically used to treat cholestatic liver disease. PureRawz sells TUDCA for laboratory and research use, not human consumption.

What is the half-life of TUDCA?

TUDCA has a half-life of between 2.1 ± 0.71 hr. [R]

Where to Buy TUDCA Online?

Pure Rawz is the best place to buy the highest-quality TUDCA online.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. We sell liquid, powder, and capsule high-quality TUDCA formulations. All the formulations are equally high-quality.

Summary

TUDCA is a water-soluble bile acid that can penetrate the blood-brain barrier. It has been shown to reduce cholestasis symptoms, alleviate the hepatitis C virus and improve functionality in patients with amyotrophic lateral sclerosis (ALS).

Speak to your medical health provider to know more. Do not rely solely on the information given.