ACTH (4-7) Pro-Gly-Pro

Description

ACTH (4-7) Pro-Gly-Pro Overview

This material consists of two synthetic peptide analogues, N-Acetyl ACTH (4-7) Pro-Gly-Pro Amidate and N-Acetyl Selank Amidate. Both compounds are modified peptide structures derived from short endogenous peptide fragments and are studied in biochemical research for their interactions with molecular signaling pathways and peptide-receptor regulatory systems.

The molecules are studied in biochemical systems to investigate peptide-mediated signaling processes and receptor-associated regulatory pathways.

Chemical Characteristics

N-Acetyl ACTH (4-7) Pro-Gly-Pro Amidate
Peptide Sequence	Met-Glu-His-Phe-Pro-Gly-Pro
Structural Analogue	Derived from an adrenocorticotropic hormone (ACTH) fragment
Chemical Modifications	N-terminal acetylation and amidation
Mechanistic Implications	Modifications influence peptide stability and enzymatic degradation kinetics
Research Context	Used in molecular and biochemical studies of peptide signaling and receptor interactions

 

N-Acetyl Selank Amidate
Peptide Sequence	Thr-Lys-Pro-Arg-Pro-Gly-Pro
Structural Analogue	Derived from tuftsin-related peptide fragments
Chemical Modifications	N-terminal acetylation and amidation
Mechanistic Implications	Modifications influence peptide conformation and resistance to proteolytic cleavage
Research Context	Used in molecular and biochemical studies of peptide signaling and receptor interactions

Molecular Activity and Signaling Pathways

Experimental investigations examine interactions between these peptides and several biochemical signaling systems, which include:

Neurotrophic Factor Regulation

Research models have evaluated interactions with pathways associated with:

• Brain-derived neurotrophic factor (BDNF) transcription
• nerve growth factor (NGF) signaling
• intracellular transcriptional regulation associated with neuronal peptide signaling.

Neurotransmitter-Associated Pathways

Peptide signaling investigations include modulation of molecular pathways linked to:

• dopaminergic signaling networks
• serotonergic regulatory pathways
• receptor-associated signaling cascades involved in neuronal communication.

Immune-Associated Signaling

Studies have explored the relationship between peptide fragments and molecular pathways such as:

• cytokine-associated signaling networks
• intracellular inflammatory transcription pathways including NF-kB regulation.

Structural Peptide Research Context

These peptides are commonly examined in molecular and biochemical research to analyze:

• peptide stability modifications through acetylation and amidation
• peptide-receptor binding dynamics
• peptide influence on intracellular transcription factors
• neuropeptide-related signaling cascades.

Research Handling Context

This material is intended exclusively for controlled laboratory investigation of peptide signaling mechanisms and molecular interaction studies.

No statements regarding safety, efficacy, or biological outcomes are provided.

Why Choose Purerawz for ACTH (4-7) Pro-Gly-Pro?

Buy ACTH (4-7) Pro-Gly-Pro for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

Reference Links

• Medvedeva, E. V., Dmitrieva, V. G., Povarova, O. V., Limborska, S. A., Skvortsova, V. I., Myasoedov, N. F., & Dergunova, L. V. (2014). The peptide ACTH (4-7) Pro-Gly-Pro affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis. BMC Genomics, 15(1), 228. https://doi.org/10.1186/1471-2164-15-228
• Sciacca, M. F., Naletova, I., Giuffrida, M. L., & Attanasio, F. (2022). ACTH (4-7) Pro-Gly-Pro, a synthetic regulatory peptide, affects Copper-Induced abeta aggregation and amyloid formation in artificial membrane models. ACS Chemical Neuroscience, 13(4), 486-496. https://doi.org/10.1021/acschemneuro.1c00707