Humanin (HNG)

Description

Humanin (HNG) Overview

HNG (Humanin G) is a synthetic derivative of Humanin, a naturally occurring mitochondrial peptide involved in cellular stress responses.

Humanin peptides have attracted scientific interest due to their potential role in cellular protection, mitochondrial signaling, and metabolic regulation. HNG was developed as a modified form of Humanin to allow researchers to further investigate these biological pathways in laboratory settings.

In experimental models, HNG is being studied for its potential neuroprotective, cytoprotective, and anti-inflammatory properties, particularly in research related to cellular stress responses, mitochondrial biology, and metabolic signaling.

Chemical and Molecular Properties

PubChem CID	16131438
Molecular Formula	C119H204N34O32S2
Molecular Weight	2687.2 g/mol
Synonyms	Formyl humanin Protein Humanin (human) 1-24-Protein humanin (human) T lymphocyte activation-associated protein PRO86272 (human)
IUPAC	24-amino acid mitochondrial-derived peptide (MDP)
CAS	832714-52-8
Labeling	Research Use Only (RUO), not for human or animal consumption
Chemical Structure Depiction
Purity	96%
Classification	Research Use Only (RUO)
Storage Temperature	Store at -20°C (-4°F) for long-term stability
Solubility	Water, DMSO (research-grade solvents)
Safety	Handle with gloves, a lab coat, eye protection; use a fume hood if dust/aerosol is possible

Mechanisms of Action

Researchers are studying HNG for its potential role in supporting cellular stability under conditions of stress.

Preclinical investigations suggest HNG may:

• Interact with pro-apoptotic proteins, which may influence cellular survival pathways
• Reduce oxidative stress in experimental models
• Support mitochondrial signaling and function
• Modulate inflammatory signaling pathways
• Influence metabolic signaling pathways, including those associated with insulin response

These mechanisms are currently being investigated in laboratory and preclinical research environments, and their relevance outside controlled research settings has not been established.

Potential Research Applications

Scientists are exploring HNG across several areas of experimental research:

Neuroprotection Research

HNG is being studied for its potential to protect neuronal cells from stress-related damage in laboratory models.

Mitochondrial Biology

Because Humanin peptides originate from mitochondria, researchers are examining HNG's potential involvement in mitochondrial signaling and cellular energy processes.

Metabolic Signaling Studies

Preclinical investigations suggest HNG may influence pathways related to insulin signaling and glucose metabolism.

Inflammatory Pathway Research

Early studies indicate HNG may interact with pathways associated with inflammatory signaling and oxidative stress responses.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

References:

1. Lue, Y., Swerdloff, R., Wan, J., Xiao, J., French, S., Atienza, V., Canela, V., Bruhn, K. W., Stone, B., Jia, Y., Cohen, P., & Wang, C. (2015). The potent humanin analogue (HNG) protects germ cells and leucocytes while enhancing Chemotherapy-Induced suppression of cancer metastases in male mice. Endocrinology, 156(12), 4511-4521. https://doi.org/10.1210/en.2015-1542
2. Kim, S. M., Kang, J., Yoon, H., Choi, Y. K., Go, J. S., Oh, S. K., Ahn, M., Kim, J., Koh, Y. S., Hyun, J. W., Yoo, E., & Kang, H. (2020). HNG, a humanin analogue, promotes hair growth by inhibiting Anagen-to-Catagen transition. International Journal of Molecular Sciences, 21(12), 4553. https://doi.org/10.3390/ijms21124553