Myostatin

Description

Myostatin Overview

In investigational research models, myostatin is widely studied to understand the molecular mechanisms governing cell growth regulation. Researchers study this protein to understand its role in regulating muscle growth and differentiation in preclinical models. 

Myostatin has become an important subject in in vitro studies and experimental molecular biology research models. It is studied to understand how growth factors interact with receptor complexes and intracellular transcriptional regulators.  

Note: Myostatin is not FDA-approved for human or animal consumption. We sell this product only for research purposes. 

PubChem CID	118705608
CAS Number	1621169-52-5
UNII	U8DGS69FVC
ChEMBL ID	CHEMBL3410227
Molecular Formula	C133H227N43O33
Molecular Weight	2956.5 g/mol
IUPAC Name	L-alanyl-L-tryptophyl-L-arginyl-L-glutaminyl-L-asparagyl-L-threonyl-L-arginyl-L-tyrosyl-L-seryl-L-arginyl-L-isoleucyl-L-alpha-glutamyl-L-alanyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-seryl-L-lysyl-L-leucyl-L-arginyl-L-leucinamide
Synonyms	1621169-52-5 (CAS Number)
Sequence	Ala-Trp-Arg-Gln-Asn-Thr-Arg-Tyr-Ser-Arg-Ile-Glu-Ala-Ile-Lys-Ile-Gln-Ile-Leu-Ser-Lys-Leu-Arg-NH₂
Usage	Research Use Only (RUO), not for human or animal consumption
Purity	Purity ≥95% (verified by HPLC or equivalent analytical method)
Solubility	Water, DMSO (research-grade solvents)
Storage Temperature	-20°C (-4°F) for long-term stability
Handling Precautions	Use gloves, a lab coat, and eye protection
Ventilation	Use a fume hood if dust/aerosol is possible

Proposed Working Mechanism of Myostatin

Myostatin binds to activin type II receptors (ActRIIA and ActRIIB) on muscle cells, which then recruit and activate type I receptors to initiate intracellular signaling. It further triggers a cascade of phosphorylation events inside the cell, as observed in in vitro studies.

This signaling cascade activates SMAD proteins, specifically SMAD2 and SMAD3, which combine with SMAD4 and move into the nucleus of the cell. 

Once inside the nucleus, the SMAD complex regulates gene expression. It suppresses genes involved in muscle cell growth and differentiation while promoting genes that inhibit muscle development in preclinical investigational models. This signaling has been associated with reduced proliferation and differentiation of muscle precursor cells in preclinical studies.

Potential Research Applications of Myostatin

• Cell Differentiation Research
• Study of myoblast proliferation and differentiation pathways 
• TGF-β Signaling Pathway Studies
• Investigation of SMAD-dependent transcriptional regulation 

Why Choose Purerawz for Myostatin?

Buy Myostatin for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

References:

• Lee, S., & McPherron, A. C. (2001). Regulation of myostatin activity and muscle growth. Proceedings of the National Academy of Sciences, 98(16), 9306-9311. https://doi.org/10.1073/pnas.151270098
• McPherron, A. C., & Lee, S. (1997). Double muscling in cattle due to mutations in the myostatin gene. Proceedings of the National Academy of Sciences, 94(23), 12457-12461. https://doi.org/10.1073/pnas.94.23.12457