Ligandrol (LGD-4033) – Product Details
Ligandrol is a novel nonsteroidal oral selective androgen receptor modulator currently being investigated in research as a potential treatment for conditions relating to muscle dystrophy and osteoporosis.
Recent studies investigated the effects of LGD 4033 on muscle tissue in ovariectomized rats. A daily dose of LGD was administered and calculated according to the body weight of each individual rat at the onset of the study.
Results and changes were noted as soon as week 2, the control group having weighed significantly less than rats undergoing LGD treatment. This difference remained until the end of the study, irrespective of LGD treatments.
Additionally, the LGD treatments resulted in a higher number of capillaries in all muscles studied. Longer randomized trials and research could potentially evaluate its efficacy in improving physical function and health outcomes in select populations.
|Molar Mass||338.253 g·mol−1|
How Does Ligandrol Work?
Ligandrol LGD-4033 works by binding androgen receptors (ARs) on a tissue-selective basis. It primarily targets ARs in the bone and muscle tissues, sparing the vital organs. This distinguishes LGD-4033 and other SARMs from testosterone and anabolic steroids, whose approach isn’t as targeted.
Ligand Pharmaceuticals developed LGD-4033 for increasing anabolic activity and the treatment of conditions such as muscle wasting and osteoporosis. This research compound was patented in 2009 and has attracted at least one clinical trial since.
In phase 1 clinical trials, this SARM has been shown to increase lean muscle mass and strength, though it also suppressed total testosterone. Animal studies have highlighted its effects on bone density and strength.
Still, the available clinical data isn’t enough to verify its safety and efficacy. Long-term randomized clinical trials are needed.
Ligandrol and Muscle Mass
In the phase 1 clinical trial, 76 healthy men (ages 21-50 years) were randomized to placebo or 0.1, 0.3, or 1.0mg LGD-4033 daily for 21 days. Among other metrics, lean and fat mass and muscle strength were measured during and for 5 weeks after intervention.
LGD 4033 increased lean body mass in a dose-dependent manner. The gains in lean body mass were similar to those reported with Ostarine, although the treatment duration in the Ostarine trial was substantially longer (12 weeks). [R] [R]
Ligandrol and Muscle Strength
The phase 1 clinical trial also noted the effect of LGD-4033 on muscle strength. An increase in muscle strength averaging 68.3N was observed among the 1.0mg dose group, but this change was not significantly different from that in the placebo group.
This 3-week study, by demonstrating the safety and tolerability of LGD-4033 and significant gains in lean muscle mass and strength, paves the way for longer-term efficacy trials.
Ligandrol and Body Fat
The abovementioned trial also evaluated the impact of Ligandrol on body fat. While subjects who were administered 1mg/day LGD 4033 experienced more fat loss than those on 0.1mg and 0.3mg daily doses, on the whole, the fat mass did not change significantly.
More extensive research and randomized trials could potentially evaluate its efficacy in reducing body fat mass and increasing muscle growth in select populations.
Ligandrol and Bone Strength
In the 62nd Annual Meeting of the Gerontology Society of America in Atlanta, data from a preclinical study on LGD-4033 was featured. It was observed that Ligandrol increased bone density and bending strength (an indicator of resistance to fracture) in osteopenic female rats. [R]
Statistically significant improvements in bone mineral density were also observed after 12 weeks of administering LGD-4033 at doses as low as 0.03mg/kg/day (in cortical bone) and 0.3mg/kg/day (in cancellous bone).
Is LGD-4033 Legal?
Ligandrol LGD-4033 is legal to buy and sell as a research compound. Like other SARMs, it can only be used for laboratory research use and isn’t approved for human consumption
Is LGD-4033 Safe?
In its only clinical trial conducted to date, LGD-4033 was well-tolerated.
There were no drug-related adverse events and the frequency of adverse events was similar between the placebo and any dose group. There were no clinically significant changes in liver enzymes, hematocrit, prostate-specific antigen, or electrocardiogram at any dose.
What is the half-life of LGD 4033?
Ligandrol LGD-4033 has a prolonged elimination half-life (24 – 36 hours) in research subjects.
Does Ligandrol suppress endogenous testosterone?
In a placebo-controlled study, there was a dose-dependent suppression of total testosterone and sex-hormone globulin levels from baseline to day 21. Upon discontinuation of LGD-4033, the hormone levels returned to baseline by day 56.
Does LGD-4033 cause liver toxicity?
In a placebo-controlled randomized clinical trial of LGD-4033 on healthy subjects, there were no clinically significant changes in liver enzymes.
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Ligandrol LGD-4033 achieved significant dose-dependent gains in lean body mass and muscle strength in a short-duration placebo-controlled clinical trial. The compound was well tolerated by the subjects and there were no drug-related adverse events.