How Does Ostarine Work?

Ostarine MK 2866 is a selective androgen receptor modulator or SARM that works by targeting androgen receptors on a selective basis. Unlike anabolic steroids or testosterone, it mainly focuses on the muscle and bone tissue, sparing the reproductive organs.

This selectivity enables Ostarine to avoid a wide range of intense side effects and has given researchers the opportunity to study this SARM in female and elderly test subjects. However, long-term and randomized human trials are needed to verify its safety.

Ostarine Research

Ostarine is one of the well-researched SARMs. Many clinical trials have been conducted on this research compound. It has also been researched in cancer patients, postmenopausal women, and the elderly. Here’s how what existing studies have to say about MK-2866:

Ostarine and Muscle Mass

A double-blind placebo-controlled trial set out to investigate the effects of Ostarine on lean body mass and physical function in healthy elderly men and postmenopausal women. It was found that Ostarine produced a dose-dependent improvement in total lean body mass and physical function. [R]

In another trial, Ostarine was studied for its effects on muscle wasting and physical function in patients with cancer. One group was administered a placebo and two groups were given Ostarine. Both MK-2866 groups experienced significant increases in total lean body mass compared to baseline levels. [R]

This shows the massive potential research implications of anabolic effects MK-2866 can possess.

Ostarine and Bone Density

Ostarine is being researched for its potential ability to improve bone density.

In a rat model of osteoporosis, MK-2866 was administered for 5 weeks to ovariectomized rats. Another ovariectomized group of rats received no Ostarine. Final analysis showed improvements in structural properties such as bone mineral density and bone volume density in the Ostarine group. [R]

In a separate study, the potential bone-healing effect of Ostarine in ovariectomized rats was investigated. The final results showed that Ostarine appears to positively affect early bone healing. Long-term and randomized human trials are needed to explore its potential as a therapy for osteoporosis. [R]

Ostarine and Heart Health

A 12-week double-blind, placebo-controlled trial was conducted to evaluate various effects of Ostarine in healthy elderly men and postmenopausal women. The trial’s subjects were divided into three groups, including 0.3mg, 1mg, and 3mg.

Ostarine treatment decreased serum triglycerides in the 1- and 3-mg groups compared to placebo. A statistically significant reduction in total cholesterol was also observed in all three groups. The 3mg group also experienced a significant decrease in blood glucose. [R]

This shows massive promise in Ostarine’s potential ability to improve heart health.

Ostarine and Diabetes

In the same trial quoted above, Ostarine brought about a decrease in insulin resistance from baseline in the 1-mg and 3-mg treatment groups. Researchers noted that the decrease was similar to that observed with glipizide and metformin, drugs used in the treatment of diabetes. [R]

However, more randomized long-term trials are needed to investigate the potential anti-diabetic effect of liquid Ostarine.

Ostarine and Fat Loss

In the same study quoted above, the effects of Ostarine treatment on fat mass in healthy elderly men and postmenopausal women were noted. A statistically significant decrease in total fat mass was observed at the 3-mg Ostarine dosage.

The decrease in fat mass from baseline in the 3mg group compared to placebo was similar in females and males. There was approximately a loss of 0.6kg relative to placebo. [R]

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Ostarine FAQs

Is Ostarine Illegal to Purchase?

Ostarine is legal to purchase as a research compound.

Like other selective androgen receptor modulators, it can be used for laboratory research use only. However, since it is on the World Anti-Doping Agency’s list, athletes and professionals should avoid this drug.

Does Ostarine Shut Down Testosterone Production?

In a double-blind placebo-controlled trial, there were no statistically significant differences in free testosterone levels in Ostarine groups relative to placebo.

Does Ostarine Make You Bigger?

Ostarine produced a dose-dependent increase in total lean body mass in the same study quoted above. Longer randomized trials and research are needed to evaluate its potential ability to help users gain muscle mass.

Summary

Ostarine has demonstrated its ability to improve lean muscle mass, reduce body fat and increase bone mineral density in a clinical study. More long-term randomized clinical trials are needed to understand its safety and efficacy in humans.