Andarine (S-4)

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Andarine (S-4) – Product Details

Andarine, also known as S-4 or GTx-007, is a selective androgen receptor modulator (SARM). A scientific study published in 2005 examined the effects of Andarine S-4 on the skeletal muscles, bones, and pituitary glands of castrated male rats. A treatment protocol (3 and 10mg/kg S4- Andarine for 8 weeks) was commenced 12 weeks after castration. Andarine (doses 3 and 10 mg/kg) restored soleus muscle mass and strength and levator ani muscle mass to that seen prior to castration or in intact animals.

In another animal study, the osteoanabolic activities of it were compared with that of dihydrotestosterone (DHT). When S-4 was administered to ovariectomized rats for 4 weeks, their femur bone mineral density and levator ani muscle weight were increased as markedly as DHT. However, prostate weight was not elevated over the normal at any doses tested.

This makes S4 an investigational Selective androgen receptor modulator for the possible treatment of conditions related to muscle wasting, osteoporosis, and benign prostatic hypertrophy (BPH). It has the ability to mimic many of the beneficial pharmacologic effects associated with testosterone.

Andarine S-4  
CAS Number 19269-85-3
Molar Mass 128.3 g/mol-1
Chemical Formula S4
IUPAC Name Tetrathietane


How Does Andarine Work?

Andarine works by targeting androgen receptors (ARs) on a tissue-selective basis. It mainly binds ARs in the muscle and bone tissue, sparing the reproductive organs. This distinguishes it from Testosterone and anabolic steroids, whose effects aren’t as limited.

An animal study published in 2003 confirmed this. It was set out to examine the in vitro and in vivo pharmacological activity of Andarine and other SARMs. The study found that the activities of S-4 were tissue-selective in that it stimulated the anabolic organs more than the androgenic organs.

While Andarine S-4 was less potent and efficacious than testosterone in androgenic activity, its anabolic activity was similar to or greater than that of testosterone. Also, it didn’t cause significant luteinizing hormone or follicle-stimulating hormone suppression at doses near the ED (50) value. [R]

Andarine Research

Andarine has been subjected to various animal studies. Almost all of them involved rats. That means that the available clinical data is insufficient to claim that it is safe for human consumption. Long-term, randomized clinical trials are needed to verify its safety and efficacy.

Andarine and Muscle Mass

Andarine was developed to treat conditions such as muscle wasting.

A recent study set out to investigate the bone anabolic effects of Andarine. The compound was administered to ovariectomized rats for 4 weeks. It was found that the muscle weight of levator ani was increased as markedly as DHT. But the prostate weight was not elevated over the norm. [R]

Another study showed similar results. Twelve weeks after castration, ovariectomized rats were administered 3 or 10mg/kg of it or 3mg/kg of DHT for 8 weeks. It restored soleus muscle mass and strength and levator ani muscle mass to that seen in intact animals. [R]

Andarine and Bone Density

In an animal study, the effects of S-4 treatment in osteopenic female rats were noted. Significant increases in cortical bone quality were observed at the femoral midshaft, resulting in increased load-bearing capacity. S-4 also demonstrated partial/total recovery of bone parameters to age-matched intact levels.

In a separate study, S-4 treatment prevented bone loss in ovariectomized rats, while in another rat study, Andarine treatment caused a significantly larger increase in bone mineral density than DHT. All these studies show massive promise in the potential bone strength increase brought on by Andarine. [R]

Andarine and Fat Loss

A study was conducted to examine the bone and body composition effects of It in ovariectomized rats. It was found that the S-4 treatment decreased body fat in these animals while increasing bone strength. [R]

More extensive research and randomized trials are needed to potentially evaluate this SARM’s efficacy in inducing fat loss in select populations.

Andarine FAQs

Is Andarine A Effective SARM?

An animal study has shown that this SARM treatment improves muscle strength and body composition and prevents bone loss in ovariectomized rats. All these effects were achieved with minimal pharmacologic effects in the prostate. [R]

Is Andarine Legal?

It is legal to purchase as a research compound.

Like other SARMs, it can be used for laboratory research use only.

What Is The Half-Life of Andarine S-4?

Andarine S-4 has a short half-life of 4 hours.

Where to Buy Andarine Online

PureRawz is the best place to buy Andarine S-4 for sale.

In order to be the best SARMs supplier, we provide reference materials with every product we sell. Each of our SARMS comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

Andarine Summary

It was developed to treat conditions such as muscle wasting, osteoporosis, and benign prostatic hypertrophy (weakening of the prostate gland).

Multiple animal studies have shown that it possesses potential muscle and bone anabolic effects. Aside from that, in at least one rat study, this compound caused fat loss. Still, long-term randomized clinical trials are needed to verify this compound’s efficacy and safety.


This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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18 reviews for Andarine (S-4)

  1. Hunter Burston

    Great compound. No sides, all gains

  2. Hugh K

    Improved my performance a lot.

  3. Matthew F

    Can highly recommend this product! The quality is nothing short of great and the results are visible.

  4. Olsen Jacobs

    Very impressed

  5. Wesley Tate

    Getting my summer body back whooo whoo!

  6. Ethan Young

    Helps get rid of water retention fast.

  7. Adam Sweeney

    Keep seeing awesome results!

  8. Kenneth Martin

    Not sure how it works, but it does. I feel stronger while working out. More endurance as well.

  9. Eric Smith

    Amazing product. It only took a couple weeks to see positive changes in my physique.

  10. Shane Barnes

    Visible muscular gains.

  11. Emett Aucamp

    Workouts are feeling great and the results looking good.

  12. Daniel Allen

    No doubt, this product is awesome

  13. Jason Singe

    I’m not sure if it’s just me, but my appetite and energy levels have increased. I will buying from you more often. Thanks, PureRawz your really awesome!

  14. Jan Roberts

    Been using a while, bone density increased amazingly at 50+.

  15. Erin

    Very happy with the results I am seeing, the amount of muscle mass I have been gaining is very impressive to say the least.

  16. Jeremy Martins

    Very happy with the amount of lean muscle mass I am gaining.
    Great strength improvements as well.

  17. John Tooley (verified owner)

  18. Robert alexander (verified owner)

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