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Centrophenoxine

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Description

Centrophenoxine – Product Information

Centrophenoxine is a cholinergic nootropic. Clinical research has shown that it may potentially improve memory in healthy elderly human subjects as well as older patients with dementia. Centrophenoxine has also been found to potentially enhance memory formation in healthy adults.

Several animal studies have reported that Centrophenoxine may potentially shield nerve cells from oxidative damage caused by stroke or toxic exposure. Additionally, the nootropic has exhibited the potential ability to increase RNA synthesis, glucose uptake, and protein synthesis in neurons.

  • Centrophenoxine is offered as 25g powder.

PureRawz sells Centrophenoxine for laboratory research use only.

Centrophenoxine
CAS Number 51-68-3
Molar Mass 257.71 g/mol
Chemical Formula C12H16ClNO3
IUPAC Name 2-Dimethylaminoethyl (4-chlorophenoxy)acetate

What is Centrophenoxine?

Centrophenoxine, also known as meclofenoxate, is a cholinergic nootropic. It is capable of increasing acetylcholine levels in the brain. This is significant given that the acetylcholine neurotransmitter regulates various crucial functions, i.e., learning, memory, etc.

The nootropic was originally developed in 1959 in France as a potential treatment for various age-related brain disorders, such as dementia. Clinical research has shown that Centrophenoxine may be helpful in medium-level dementias in quite old groups of patients. [R]

In preclinical studies, Centrophenoxine has demonstrated the potential ability to protect nerve cells from oxidative damage. It may also reduce the damage caused by free radicals, increase the activity of major antioxidants in the brain, and expedite energy use in the brain’s cells. [R][R][R]

How does Centrophenoxine Work?

Centrophenoxine is made up of two chemical compounds: Dimethyl-aminoethanol (DMAE) and parachlorphenoxyacetic acid (pCPA). DMAE, a natural substance found in some foods and in small amounts in the brain, is the main active ingredient of this compound.

Once it is absorbed in the human body, Centrophenoxine is potentially broken down into DMAE and pCPA. Afterward, DMAE reportedly converts to choline before crossing the blood-brain barrier, while the remaining Centrophenoxine circulates through the bloodstream. [R][R]

Here are the proposed mechanisms of action for Centrophenoxine:

  • Potentially Increases acetylcholine in the brain. Acetylcholine is a major neurotransmitter that contracts smooth muscles, slows heart rate, and dilates blood vessels. It is thought to play a major role in memory and learning. [R][R]
  • Potentially Increases glucose uptake. At least two preclinical studies have demonstrated that Centrophenoxine may potentially increase glucose uptake (more energy) and promotes blood flow (more oxygen) within the brain and neurons. [R][R]
  • Potentially Enhances RNA production. In one of the above clinical studies, Centrophenoxine was found to potentially cause protein turnover in neurons, boosting RNA production. This effect was more evident in neurons where damaged proteins could be replaced. [R]
  • Reduces lipofuscin levels. Lipofuscin is an aging pigment that potentially builds up in cells (including neurons) with age. It is responsible for causing brown liver spots on the skin. CPH has been shown to reduce lipofuscin concentrations in animals. [R]

Centrophenoxine Research

What follows is a summary of the available research on Centrophenoxine. The information offered in this section is for information purposes only.

Centrophenoxine and Dementia

In a double-blind placebo-controlled trial, elderly dementia patients were administered Centrophenoxine or a placebo. Results from the trial show that Centrophenoxine treatment may have caused improvement in memory functions in 48% of patients against 28% of the placebo group. [R]

Another trial explored the effects of Centrophenoxine and another synthetic compound on elderly patients with senile dementia of Alzheimer’s type (SDAT). Prolonged treatment with both compounds potentially improved cognitive performance (attention, concentration, memory, IQ). [R]

Lastly, a double-blind pilot trial studied the effects of Centrophenoxine on the mental ability of older patients with mild-to-moderate degrees of dementia. Results from this study show that the CPH group potentially improved on all key metrics compared with control group members. [R]

Centrophenoxine and Neuroprotection

Results from a preclinical study show that Centrophenoxine potentially increases the activity of antioxidants in the brain. This finding led the researchers to conclude that CPH supplementation may be potentially beneficial in combating oxidative stress conditions in the aging brain. [R]

In another preclinical study, Centrophenoxine potentially reduced the reduction of lipofuscin (the age pigment) and had a positive effect on cell metabolic functions. The nootropic also reportedly caused a delay in the aging of glial cells (non-neuronal cells in the central nervous system). [R]

Additionally, when administered to rats with various types of brain injury, it prevented some cognitive deficits that may have been caused by elevated oxidative stress.

CPH was found to thwart impairments to memory, motor control, and overall cognitive function. [R]

Centrophenoxine and Learning & Memory

In a clinical study involving 60 healthy elderly individuals, Centrophenoxine treatment reportedly promoted the formation of long-term memories. A significant number of subjects receiving the nootropic also potentially increased an increased level of mental alertness. [R]

A preclinical study was made to examine the effects of this nootropic compound on learning and memory. The treated animals learned the devised task in fewer attempts than untreated ones.

The compound also significantly improved memory in old mice after three months of treatment. [R]

Centrophenoxine and Lifespan

Results from an animal study demonstrated that Centrophenoxine increased the lifespan of treated mice by up to 40%. CPH was found to reduce the activity of four substances – lipofuscin pigments, lysosomal enzymes, acid phostase, and simple esterase – implicated in the aging process. [R]

Another animal study found that Centrophenoxine may reverse the effects of aging in the brain. It could reportedly do that by reducing lipofuscin concentration and lipid peroxidation. However, clinical research is needed to examine the effects of CPH on aging in humans. [R]

Where to Buy Centrophenoxine?

PureRawz is the best place to buy Centrophenoxine capsules.

In order to be the best supplier of research peptides, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin.

Check out reviews to know what existing customers have to say about our product purity and appropriate handling methods.

Centrophenoxine Summary

Various clinical trials have shown that Centrophenoxine possesses the potential to be a useful therapeutic treatment for dementia. In preclinical studies, this nootropic has exhibited the potential ability to induce neuro-protection, increase lifespan and enhance learning and memory.

Long-term clinical studies are needed to fully understand the safety and associated risks of Centrophenoxine powder and capsules.

Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.
All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA). Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon. By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

8 reviews for Centrophenoxine

  1. Paul McC

    I can feel the difference when I use this, it works amazingly well.

  2. Owen Giroud

    I most certainly felt the effects in my day-to-day life. You guys are life savers thank you so much

  3. Angel

    Being a student, busy with exams, this really helped with my concentration and focus.

  4. Anonymous

    Highly recommended. If you have brain fog for any reason, give this a try. Most helpful.

  5. F. Lewis

    I’ve been taking them for a few weeks now and feel like things have improved. I think I am a bit more focused and find that my mind isn’t wandering as much. I hope this helps others.

  6. Stefan O

    Will buy again.

  7. Caitlen Thirston

    Shipping was a bit delayed. But the results of this product speak for it self.

  8. Anonymous

    If you have brain fog for any reason, give this a try. Most helpful. Highly recommended.

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