Description

SNAP-8

SNAP-8 (Acetyl Octapeptide-3) is a synthetic octapeptide composed of 8 amino acids. It is an elongated analogue of Argireline (Acetyl Hexapeptide-3), originally developed by Lipotec (now Lubrizol) for cosmetic-formulation and biochemical research.

SNAP-8 is studied in preclinical and in vitro research settings for molecular interactions spanning the SNARE-complex signaling pathway and neuromuscular junction research parameters. It is available in 10mg and 100mg fill sizes.

RESEARCH USE ONLY: This product is intended for laboratory research and cosmetic-formulation purposes only. We do not sell this product for human or animal consumption.

Available Fill Sizes

Fill Size	Catalog Code	Format	Best Suited For
10mg	SNAP8-10	White lyophilized powder, single vial	Standard research quantities, individual testing
100mg	SNAP8-100	White lyophilized powder, single vial (bulk)	Larger-scale formulation and research batching

Chemical and Molecular Properties

Property	Value
PubChem CID	71587832
Synonyms	Acetyl Octapeptide-3; Acetyl Glutamyl Heptapeptide-1 (INCI); formerly Acetyl Glutamyl Heptapeptide-3 (older INCI designation)
Sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
Molecular Formula	C42H72N16O15S
Molecular Weight	1,073.2 g/mol
IUPAC	Available per Certificate of Analysis
CAS	868844-74-0
Purity	Verify per batch COA (HPLC verified)
Physical Form	White lyophilized powder
Solubility	Soluble in sterile water
Shelf Life	Verify per Certificate of Analysis
Classification	Research Use Only (RUO); regulated as a cosmetic ingredient under FDA's MoCRA framework, not a bulk drug substance

Proposed Working Mechanism of SNAP-8

Investigational findings indicate that SNAP-8 may competitively occupy a binding position within the SNARE complex normally used by native SNAP-25. In preclinical and cell-based research models, this interaction has been associated with reduced acetylcholine release at the neuromuscular junction.

Research data suggests SNAP-8's potential to reduce muscle micro-contraction signaling without cleaving SNAP-25, a mechanistically different approach from botulinum toxin, which cleaves the protein directly. This mechanism has been proposed to underlie observations related to expression-line and formulation research noted across manufacturer and analytical literature.

Studies conducted in controlled laboratory environments have observed that SNAP-8's added length relative to Argireline may influence binding affinity and formulation stability. This interaction is of particular investigational interest in the context of cosmetic-formulation and peptide structure-function research.

Note: SNAP-8 is an investigational research and cosmetic-formulation compound. Independently published, peer-reviewed clinical trial data specific to SNAP-8 remain limited; most efficacy figures originate from manufacturer (Lipotec) technical documentation rather than FDA-reviewed human clinical trials.

Possible Research Applications of SNAP-8

SNAP-8 is a synthetic peptide that has gained attention in cosmetic-science and biochemical research for its potential research applications, which include:

SNARE-Complex Binding Research Preclinical investigations in laboratory models have recorded measurable shifts in SNAP-25 occupation and competitive binding metrics. Interaction kinetics and receptor/protein occupation profiles were documented as key parameters.

Neuromuscular Signaling Research Investigational studies have yielded quantifiable data on acetylcholine release parameters, neuromuscular junction signaling markers, and downstream muscle micro-contraction measurements in research settings.

Cosmetic Formulation & Stability Research Investigational findings have documented peptide stability under varying pH and temperature conditions, relevant to topical formulation research and shelf-life modeling.

Comparative Peptide Research Preclinical studies have recorded notable comparative data between SNAP-8 and its shorter parent peptide, Argireline, within structure-function research frameworks.

Research Stability & Handling Profile

SNAP-8 exhibits notable stability characteristics that distinguish it within the peptide research space.

Storage Recommendations for Research Use:

• Store lyophilized SNAP-8 at -20°C in a sealed, desiccated environment
• Once reconstituted for laboratory use, maintain at 2–8°C and utilize within established research protocol timeframes
• Avoid repeated freeze-thaw cycles to preserve peptide integrity for research purposes
• Keep away from UV light exposure during storage
• For reconstitution, use sterile water appropriate to the intended research or formulation protocol

Risk & Handling

• SNAP-8 is intended for research and formulation purposes only and should be handled by trained professionals using appropriate laboratory procedures and safety protocols.
• Due to limited independent clinical data, the full safety profile, potential adverse effects, and long-term implications remain under investigation.
• Researchers should avoid direct exposure through inhalation, ingestion, or skin contact and use suitable protective equipment during handling.
• Materials should be stored in a cool, dry, and controlled environment away from heat, moisture, and direct sunlight to maintain stability and integrity.
• All preparation and handling equipment should be sterile and properly maintained to reduce the risk of contamination or compromised results.
• SNAP-8 should not be marketed or represented as an approved treatment, cure, or preventive solution for any condition without regulatory authorization.
• Proper documentation, labeling, and disposal procedures should be followed in accordance with institutional, local, and national regulations.

PureRawz Quality & Purity Standards

PureRawz is committed to supplying the USA research and formulation community with high-integrity investigational compounds. Every batch of SNAP-8 is confirmed by independent HPLC analysis, with a Certificate of Analysis (COA) available per lot.

Note: SNAP-8 is an investigational research and cosmetic-formulation compound and has not been established as safe or effective for any therapeutic use.

Frequently Asked Questions

Can I legally order SNAP-8 in the US? 

Yes. It's sold as a research/cosmetic ingredient, not a drug, so it's legal to order for lab or formulation use.

Do I need a license to buy it? 

No license is needed to purchase it, but it should only be used by trained people in a real lab or formulation setting not at home.

Should I get 10mg or 100mg? 

Same peptide either way. 10mg is fine for smaller research needs; 100mg costs less per milligram and suits bigger batches.

Does SNAP-8 really work like people say online? 

Some of it is real science, but the biggest claims (like "63% wrinkle reduction") come from the manufacturer's own studies, not outside researchers. Take those numbers with a grain of salt.

What do people actually use SNAP-8 for? 

Mostly to study how it might soften expression lines, by blocking the same signal Botox blocks without freezing the muscle.

How do I store it once it arrives? 

Freezer, at -20°C, away from light and moisture. Once mixed with water, keep it in the fridge and use it soon.

Is it safe? 

Nobody knows for sure yet. It hasn't gone through full human safety trials, so long-term effects aren't established.

Can I use this as an actual skincare treatment? 

No. It's not approved for that. It's sold strictly for research and formulation testing, not as a finished product to use on skin.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co.

ATTENTION: All our products are for LABORATORY, RESEARCH, AND FORMULATION PURPOSES ONLY, not for veterinary or human use.

Reference Links

• National Center for Biotechnology Information (NCBI). Acetyl octapeptide-3, PubChem CID 71587832. National Institutes of Health. https://pubchem.ncbi.nlm.nih.gov/compound/Acetyl-octapeptide-3
• Jung, J. H., Lee, H. S., Kim, Y., et al. (2020). Method development for acetyl octapeptide-3 analysis by liquid chromatography-tandem mass spectrometry. Journal of Analytical Science and Technology, 11, 37. https://doi.org/10.1186/s40543-020-00232-8
• Blanes-Mira, C., Clemente, J., Jodas, G., et al. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science, 24(5), 303–310. https://doi.org/10.1046/j.1467-2494.2002.00153.x