What is IGF-1 LR3?

IGF-1, or insulin-like growth factor, is a potent growth factor found in mammalian blood. This peptide manages and regulates growth hormone levels (GH). IGF-1 LR3 is a shortened form of IGF-1, and some researchers recognized it as a most potent growth factor.

IGF-1 LR3 is an 83-amino acid chemically altered amino acid chain. At position 3 on the chain, Glu(E) was replaced with Arg(R), giving rise to the name LR3. Making this substitution at position three prevents IGF-1 from binding proteins in the body, increasing the half-life.

Possible Applications of IGF-1 LR3

Numerous clinical studies and trials have been done on insulin-like growth factors. Below we will highlight some of the potential future research implications of IGF-1 LR3 known as IGF-binding proteins.

May Potentially Promote the Cell Division

Like IGF-1, IGF-1 LR3 is a potentially potent stimulus for proliferation and cell division. Its primary potential effects are believed to be on connective tissues like muscle and bone. But, it may also promote cell division in kidneys, liver, skin, nerves, lungs, and blood tissues. [R]

It is important to note that research studies suggest that IGF-1 LR3 and all IGF-1 derivatives do not promote cell enlargement but rather promote cell division and proliferation.

For example, in the potential case of muscle, IGF-1 LR3 may not cause muscle cells to grow and enlarge, but it may increase the total number of muscle cells. [R]

This feature of IGF-1 LR3 demands more research.

Potentially Boosts Fat Metabolism and Fights Diabetes

IGF-1 LR3 is believed to help in reducing blood sugar levels. It may also potentially boost fat metabolism in an indirect manner by binding to both the insulin and IGF 1R receptor. These actions may increase glucose uptake from the blood by muscle, liver, and nerve cells. [R]

According to a research study done in 2013, this may potentially result in an overall decrease in blood sugar levels, which could then possibly trigger adipose tissue as well as the liver to begin breaking down glycogen and triglycerides. Which could potentially produce a net decrease in adipose tissue and net energy consumption. [R]

This makes IGF-1 LR3 a derivative of insulin-like growth factor, a possible treatment modality in decreasing insulin requirements of type 2 diabetes patients. [R]

Despite such health benefits, the research chemical still warrants deeper and large-scale clinical trials.

May Potentially Impair Myostatin

Myostatin (a.k.a. growth differentiation factor 8) is a muscle protein that primarily inhibits the growth and differentiation of muscle cells. [R]

In mouse models of DMD, it has been found that IGF-1 R3 and other IGF-1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis. It appears to counteract myostatin by activating a muscle protein called MyoD. [R]

How Does IGF-1 LR3 Work?

Research shows IGF-1 LR3 works by potentially binding to cell receptors in muscle cells and activates cell communication, which could potentially lead to improvements in muscle growth and the growth rate of muscles.

IGF-1 LR3 may also potentially obstruct the movement of glucose into cells. This may possibly facilitate fat burning and the use of fat for the production of energy.

Safety and Side Effects

Hypoglycemia is a serious and potentially fatal side effect of taking IGF-1 LR3. Hypoglycemia is a dangerously low blood sugar level that causes shaking, sweating, dizziness, hunger, confusion, and loss of consciousness.

Frequently Asked Questions

What is the difference between IGF-1 and IGF-1 LR3?

The difference between IGF-1 and IGF-1 LR3 is that the latter possesses an arginine instead of a glutamic acid at the third point of its amino acid sequence. [R]

It is also more potent and can be sustained for much longer. IGF-1 LR3 peptide may additionally inhibit the movement of glucose into cells to facilitate fat burning. [R]

Lastly, IGF-1 LR3 does not adhere to IGF-binding proteins in a similar manner to that of IGF-1. Thus, the modified version is found to remain in the bloodstream longer than IGF-1.

What is the half-life of IGF-1 LR3?

Research shows the half-life of IGF-1 is very short, and as a result, it is quickly destroyed. This is the main reason why IGF-1 was modified to produce an amino acid analog IGF-1 LR3 which has a longer half-life.

The half-life of IGF-1 LR3 is about 20 – 30 hours.

Is IGF-1 LR3 illegal to purchase?

IGF-1 LR3 is legal to purchase as a research compound.

It can be used for laboratory research use only. However, since it is on the World Anti-Doping Agency’s list, athletes and professionals should avoid this compound.

What other research chemical works well with IGF-1 LR3?

Ipamorelin is a known experimental compound that could work synergistically with IGF-1 LR3.

Where to buy IGF-1 LR3 online?

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