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IGF-1 LR3 – Product Information

  • Our IGF-1 LR3 kit ships overnight, ensuring swift delivery, and comes equipped with an ice pack for optimal product integrity during transit.

For research purposes, it is recommended to reconstitute this compound with Acetic Acid 0.6%. The addition of acetic acid to the IGF solution plays a vital role in preserving its activity by maintaining pH balance and stability. Furthermore, acetic acid assists in ensuring proper dispersion and enhancing the solubility of the IGF compound, preventing degradation.

IGF-1 LR3 refers to an altered peptide that functions similarly to insulin in the body. It is thought to stimulate growth by increasing growth hormone secretion from the pituitary gland and regulating cell growth and cell death.

The pituitary gland’s function and the hormones it secretes, decline with age; however, IGF-1 LR3 can bypass the mentioned organ and elicit the same response as growth hormone.

Although IGF-1 LR3 can help patients with a hormone deficiency, it is still recognized as an experimental chemical. Therefore, IGF-1 LR3 is not recommended for human consumption.

IGF1 LR3 Receptor Grade
CAS Number 946870-92-4
Molar Mass 9117.60 g/mol
Chemical Formula C400H625N111O115S9
IUPAC Name insulin-like growth factor-1 long arginine 3

What is IGF-1 LR3?

IGF-1, or insulin-like growth factor, is a potent growth factor found in mammalian blood. This peptide manages and regulates growth hormone levels (GH). IGF-1 LR3 is a shortened form of IGF-1, and some researchers recognized it as a most potent growth factor.

IGF-1 LR3 is an 83-amino acid chemically altered amino acid chain. At position 3 on the chain, Glu(E) was replaced with Arg(R), giving rise to the name LR3. Making this substitution at position three prevents IGF-1 from binding proteins, increasing the half-life.

IGF-1 LR3 vs IGF-1 DES

IGF-1 DES and IGF-1 LR3 are two different forms of insulin-like growth factor 1 (IGF-1), each with distinct characteristics and mechanisms of action. Here are the key differences between IGF-1 DES and IGF-1 LR3:

IGF-1 DES is a shortened form of IGF-1 that consists of the first three amino acids of the IGF-1 sequence (des(1-3)). It has a shorter half-life compared to the full-length IGF-1 and lacks the C-terminal extension found in IGF-1 LR3.

IGF-1 LR3 is a modified form of IGF-1 that has a longer half-life than the native IGF-1. It contains a modified amino acid sequence with the substitution of arginine for glutamic acid at position 3 (hence “Long R3”). This modification allows for increased stability and a prolonged duration of action.

Both IGF-1 DES and IGF-1 LR3 are believed to exert their effects by binding to the IGF-1 receptor (IGF-1R). Activation of the IGF-1R signaling pathway plays a crucial role in various cellular processes, including cell growth, proliferation, and differentiation. However, due to their structural differences, IGF-1 DES and IGF-1 LR3 may have varying affinities for the IGF-1R and interact differently with other binding proteins.

Possible Applications of IGF-1 LR3

Numerous clinical studies and trials have been done on insulin-like growth factors. Below we will highlight some of the potential future research implications of IGF-1 LR3 known as IGF-binding proteins.

May Potentially Promote the Cell Division

Like IGF-1, IGF-1 LR3 is a potentially potent stimulus for proliferation and cell division. Its primary potential effects are believed to be on connective tissues like muscle and bone. It may, however, also promote cell division in the kidneys, liver, skin, nerves, lungs, and blood tissues. [R]

It is important to note that research studies suggest that IGF-1 LR3 and all IGF-1 derivatives do not promote cell enlargement but rather promote cell division and proliferation.

For example, in the potential case of muscle, IGF-1 LR3 may not cause muscle cells to grow and enlarge, but it may increase the total number of muscle cells. [R]

This feature of IGF-1 LR3 demands more research.

Potentially Boosts Fat Metabolism and Fights Diabetes

IGF-1 LR3 is believed to help in reducing blood sugar levels. It may also potentially boost fat metabolism in an indirect manner by binding to both the insulin and IGF 1R receptor. These actions may increase glucose uptake from the blood by muscle, liver, and nerve cells. [R]

According to a research study done in 2013, this may potentially result in an overall decrease in blood sugar levels, which could then possibly trigger adipose tissue, as well as the liver to begin breaking down glycogen and triglycerides. This could potentially produce a net decrease in adipose tissue and net energy consumption. [R]

This makes IGF-1 LR3 a derivative of insulin-like growth factor, a possible treatment modality in decreasing insulin requirements of type 2 diabetes patients. [R]

Despite such health benefits, the research chemical still warrants deeper and large-scale clinical trials.

May Potentially Impair Myostatin

Myostatin (a.k.a. growth differentiation factor 8) is a muscle protein that primarily inhibits the growth and differentiation of muscle cells. [R]

In mouse models of DMD, it has been found that IGF-1 R3 and other IGF-1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis. It appears to counteract myostatin by activating a muscle protein called MyoD. [R]

How Does IGF-1 LR3 Work?

Research shows IGF-1 LR3 works by potentially binding to cell receptors in muscle cells and activates cell communication, which could potentially lead to improvements in muscle growth and the growth rate of muscles.

IGF-1 LR3 may also potentially obstruct the movement of glucose into cells. This may possibly facilitate fat burning and the use of fat for the production of energy.

Safety and Side Effects

Hypoglycemia is a serious and potentially fatal side effect of IGF-1 LR3 in research subjects. Hypoglycemia is a dangerously low blood sugar level that causes shaking, sweating, dizziness, hunger, confusion, and loss of consciousness.

Frequently Asked Questions

What is the difference between IGF-1 and IGF-1 LR3?

The difference between IGF-1 and IGF-1 LR3 is that the latter possesses an arginine instead of a glutamic acid at the third point of its amino acid sequence. [R]

It is also more potent and can be sustained for much longer. IGF-1 LR3 peptide may additionally inhibit the movement of glucose into cells to facilitate fat burning. [R]

Lastly, IGF-1 LR3 does not adhere to IGF-binding proteins in a similar manner to that of IGF-1. The modified version is thus found to remain in the bloodstream longer than IGF-1.

What is the difference between IGF-1 LR3 media grade and receptor grade?

When it comes to IGF-1 LR3, the terms “media grade” and “receptor grade” refer to different qualities or purities of the peptide. Here’s a breakdown of the differences:

  1. Media Grade IGF-1 LR3: Media Grade IGF-1 LR3 refers to a lower purity version of the peptide that is commonly used in laboratory research and cell culture studies. It is primarily intended for use as an additive in cell culture media, where it can provide growth factors to support cell growth and proliferation. Media grade IGF-1 LR3 may contain impurities and is not suitable for human use.
  2. Receptor Grade IGF-1 LR3: Receptor Grade IGF-1 LR3, also known as pharmaceutical grade or research grade, refers to a higher purity version of the peptide that meets strict quality standards. It is commonly used in research settings, preclinical studies, and sometimes in clinical trials. Receptor grade IGF-1 LR3 undergoes a more rigorous purification process to remove impurities and ensure a higher level of quality and consistency.

What is the half-life of IGF-1 LR3?

Research shows the half-life of IGF-1 is very short, and as a result, it is quickly destroyed. This is the main reason why IGF-1 was modified to produce an amino acid analog IGF-1 LR3 which has a longer half-life.

The half-life of IGF-1 LR3 is about 20 – 30 hours.

Is IGF-1 LR3 illegal to purchase?

IGF-1 LR3 is legal to purchase as a research compound.

It can be used for laboratory research use only. However, since it is on the World Anti-Doping Agency’s list, athletes and professionals should avoid this compound.

What other research chemical works well with IGF-1 LR3?

Ipamorelin is a known experimental compound that could work synergistically with IGF-1 LR3.

Where to buy IGF-1 LR3 online?

PureRawz is the best place to buy IGF-1 LR3.

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This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.
All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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COA IGF 1 LR3 lot IGH902 2023 08 28 PR 1

27 reviews for IGF-1 LR3

  1. User Avatar: Gilbert A.

    Gilbert A. (verified owner)

    Best pumps ever had

  2. Brian (verified owner)


  3. Bill (verified owner)

    Good quality

  4. Anonymous (verified owner)

    Good experience

  5. Allen McIver (verified owner)

    Fast delivery and they have notifications to let you know every step of the delivery!

  6. John R. (verified owner)

    This stuff is legit

  7. Aaron M. (verified owner)

    Very fast and always quality stuff

  8. Harvey W. (verified owner)


  9. Anonymous (verified owner)

    I found this product to be very good

  10. Johnny (verified owner)

    Great product and exactly as described!

  11. Mark Antony S

    I am very impressed with my results – this is really an awesome product.

  12. Darrel

    The product is excellent and I didn’t even have to wait very long at all to get my order. Your team is always so friendly.

  13. Duke Christoff

    After what I have achieved so far using this, you guys have earned respect. Keep up the good work

  14. Dan Kueog

    Highly recommended by my training friends and so far I’m happy using this product.

  15. Fernando

    I’ve lost a few pounds after a long-standing plateau because of this product, and it’s only been a week! I am very happy and can’t wait to keep going!

  16. F Lambert

    Assisted me with losing those last stubborn kilo’s.

  17. Jimie Savage

    This is legit!

  18. Anonymous

    Insane gains from these, absolutely loving it.

  19. Lorenza

    The BEST IGF I ever tried!

  20. Russell Erickson

    Increase in lean muscle has been impressive, love shredding.

  21. Darryl Boyle

    Highly recommended!

  22. Anthony

    Helps me recover after an intense exercise or injury.

  23. Pablo Curiel

    i like the product and have purchased it several times.what is the best dilution ration folks have used?

  24. Jessie Parker (verified owner)

  25. Greg Moore (verified owner)

    Good stuff

  26. Anonymous (verified owner)

  27. Andrew (verified owner)

    Definitely noticed a rush of energy after taking.

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