Description

What is L-carnitine + Synephrine + SR-9011 + GW-0742 ?

Combining L-carnitine, Synephrine, SR-9011, and GW-0742 synergizes each compound’s effect, increasing fat burning, energy output, and metabolic efficiency. As such, the may improve exercise performance, boost fat reduction, improve body composition, and promote overall health and wellness.

Possible Combined Benefits of L-carnitine + Synephrine + SR-9011 + GW-0742

1. 1. May potentially enhance fat burning: L-carnitine facilitates the transport of fatty acids into mitochondria for energy production, while synephrine, SR-9011, and GW-0742 promote fatty acid oxidation, thermogenesis, and metabolic rate, collectively leading to increased fat burning.
   2. Synephrine, SR-9011, and GW-0742 have thermogenic properties that can increase metabolic rate, potentially aiding in weight loss and calorie burning. Combining these compounds may improve exercise performance by increasing energy levels and endurance, reducing fatigue, and promoting efficient energy utilization.
   3. Muscle Growth and Recovery: GW-0742, in particular, may support muscle growth and recovery by stimulating mitochondrial biogenesis and promoting muscle repair processes.

1. Appetite Suppression: Synephrine has been reported to have appetite-suppressing effects. These effects, combined with the metabolic effects of the other compounds, could aid in weight management by reducing calorie intake.
2. Improved Lipid Metabolism: SR-9011 and GW-0742 may improve lipid metabolism, leading to fat loss. and;
3. May potentially regulate Circadian Rhythms: SR-9011’s activation of Rev-Erbα may help regulate circadian rhythms, potentially improving sleep quality and overall well-being.

What is L-carnitine?

Levocarnitine, a naturally occurring chemical, transports fatty acids into mitochondria for energy synthesis. It is maintained through dietary absorption, biosynthesis, and kidney reabsorption.[R] The primary sources of dietary carnitine are red meat and dairy products. However, supplements for carnitine deficiency and other diseases are increasingly available. These supplements have lower bioavailability than food-derived l-carnitine. It slowly travels between blood cells and plasma and is primarily removed by urine [R][R].

L-carnitine
CAS	541-15-1
Molar Mass	161.20 g/mol
Chemical Formula	C7H15NO3
IUPAC Name	(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate

How does L-carnitine work?

The body can use the amino acids lysine or methionine to generate levocarnitine, but ascorbic acid, or vitamin C, is necessary for this process. The carrier molecule levocarnitine carries Long-chain fatty acids across the inner mitochondrial membrane. Moreover, it carries acetyl groups from cells and subcellular organelles to the urine, where they build up to harmful amounts. Lipid metabolism is only influenced by the L isomer of carnitine, sometimes called vitamin BT. Levocarnitine has an excellent range of targets to interact with due to the involvement of several proteins, such as translocases, acetyltransferases, palmitoyltransferases, and carnitine transporters. The “vitamin BT” form contains D L-carnitine, which competitively inhibits levocarnitine and can cause deficiency [R].

The metabolic activity of L-carnitine boosts its body-wide effects. L-carnitine transports long-chain fatty acids into mitochondria for energy production in lipid metabolism. This function produces energy and removes toxic acyl groups from cells and organelles. Thus, L-carnitine improves metabolic health, endurance, and energy use [R] [R].

L-carnitine Investigations

• May potentially aid weight loss [R] [R] [R] [R]
• May act as a potential antioxidant [R] [R] [R]
• May potentially treat cardiovascular diseases [R]
• May prevent breast cancer [R]
• May potentially work with hyperthyroidism [R]

L-carnitine Safety and Side Effects

Several studies have shown L-carnitine’s safety to test subjects. One clinical investigation on L-carnitine provided two g/days and found no adverse effects or anomalies in blood markers such as liver and renal function. However, like other drugs, L-carnitine can still have adverse effects from improper dosage and adulteration [R].

What is Synephrine?

Synephrine is a proto-alkaloid derived from extracting the immature fruits of Citrus aurantium. It is also found in other citrus species (Citrus aurantium) extracts, which are widely used in some drugs for weight management and sports performance due to their thermogenic and lipolytic qualities. It is often paired with caffeine and other ingredients in products designed to support weight management [R]. Synephrine has fewer side effects and is less harmful to the liver than other phenylethanolamines and catecholamines. Reviews, including one by Stohs et al., found no evidence of adverse effects at usual doses[R].

Synephrine
CAS	94-07-5
Molar Mass	167.20 g/mol
Chemical Formula	C9H13NO2
IUPAC Name	4-[1-hydroxy-2-(methylamino)ethyl]phenol

How does Synephrine work?

Research suggests that synephrine is an adrenergic receptor agonist that primarily affects β-ARs, a receptor that is abundant in all human cell types. It operates on various adrenergic and serotonergic receptors and affects trace-amine-associated receptors. It exhibits multiple biological effects on a wide range of molecular targets. However, only p- and m-synephrine have been identified among its three positional isomers to reduce weight significantly. One probable synephrine mechanism for both hemodynamic and metabolic effects relies on stimulation of the adrenergic (α1 and β1) receptors present in the liver[R] [R].

A study demonstrated that synephrine and caffeine boosted fat oxidation during exercise while not affecting energy expenditure or heart rate. However, co-administration of caffeine and synephrine did not increase fat oxidation further, and synephrine did not affect heart rate[R] [R].

Synephrine Investigations

• May aid in weight loss [R]
• May have anticancer potential [R] [R]
• It may have anti-inflammatory effects [R] [R]
• May potentially induce antidepressant effects [R][R]
• May have antihypertensive activity [R]
• May help with asthma [R]
• May treat Parkinson’s Disease [R]

Synephrine Safety and Side Effects

It has been said not to be used in some situations, but research contradicts these suggestions. Several studies demonstrated that p-synephrine in citrus products had no adverse effects. Scientific evidence supports the safety of synephrine, indicating its safety for oral intake at recommended levels based on investigations in animals, humans, and cell cultures. Furthermore, no teratogenicity or mutagenicity was observed, even at doses up to 100 mg daily. Structural differences ensure that synephrine exhibits little or no CNS and cardiovascular stimulation, as compared to ephedrine, norepinephrine, m-synephrine, and amphetamine. Still, there is a need for additional research to fully understand the risks and benefits of Synephrine [R] [R].

What is SR-9011?

SR-9011, an SR9009 analog, is a synthetic agonist of the nuclear receptor REV-ERB (composed of REV-ERBα and REV-ERBβ). This receptor may aid in modulating the body’s circadian rhythm and postpone the senescence of human dermal fibroblast cells. These target receptors regulate the circadian rhythm and metabolic activities in the body. Thus, SR9011 may activate these receptors to modulate physiological functioning, which may have many benefits [R][R].

SR-9011
CAS	1379686-29-9
Molar Mass	479.0 g/mol
Chemical Formula	C23H31ClN4O3S
IUPAC Name	3-[[(4-chlorophenyl)methyl-[(5-nitrothiophen-2-yl)methyl]amino]methyl]-N-pentylpyrrolidine-1-carboxamide

How does SR-9011 work?

REV-ERB is essential to SR9011’s mechanism of action. These nuclear receptors control circadian and metabolic pathway genes, which promote the repression of essential circadian genes like BMAL1 and CLOCK, aligning physiological processes with a new rhythmic pattern. SR9011 may also impact metabolic processes by influencing lipid and glucose metabolism genes, resulting in increased fatty acid oxidation and reduced lipogenesis, thus improving metabolic profiles and physical endurance. SR9011 also suppresses the production of pro-inflammatory molecules, potentially reducing inflammation in various tissues. It achieves these benefits without acting as a central nervous system stimulant or significantly affecting cardiovascular parameters [R] [R].

SR-9011 Investigations

• Potentially aids in circadian or sleep disorders [R]
• Potentially prevents and treats cancer [R]
• Possesses potential anti-aging effects [R]
• It may potentially facilitate weight loss [R].
• Potentially protects neurons or treats Alzheimer’s disease [R][R]

SR-9011 Safety and Side Effects

While preclinical investigations indicate that SR9011 efficiently alters circadian rhythms and metabolic pathways without causing significant harm to major organs, its long-term safety in animal models remains unknown. Thus, extensive clinical trials are required to determine its safety, effectiveness, and potential side effects.

What is GW-0742?

GW-0742 is a synthetic high-affinity peroxisome proliferator-activated receptors-β/δ (PPAR-β/δ) agonist. These target receptors, also termed ‘lipid-sensing’ peroxisome proliferator-activated receptors (PPAR-γ and PPAR-δ), play a critical function in lipid and glucose homeostasis [R] [R].

GW-0742
CAS	317318-84-6
Molar Mass	471.5 g/mol
Chemical Formula	C21H17F4NO3S2
IUPAC Name	2-[4-[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl]methylsulfanyl]-2-methylphenoxy]acetic acid

How does GW-0742 work?

GW-0742, like other PPAR-β/δ agonists, stimulates the nuclear receptor PPAR-β/δ, leading to alterations in gene expression and physiological changes. The activation of the receptors causes various downstream effects, including increased fatty acid oxidation in skeletal muscle and cholesterol flow from peripheral tissues. Research using PPAR-δ ligands suggests this understudied isoform may be a potential target for therapy for cancer, infertility, and dyslipidemia [R] [R].

GW-0742 Investigations

• May have the potential to treat a variety of ischemia-reperfusion diseases [R]
• Potentially reduce fatty liver [R]
• May reduce atherosclerosis [R]
• May reduce neointimal hyperplasia by suppressing thickening of the artery’s intima after injury [R]
• May aid in regulating blood sugar or have antidiabetic effects [R] [R]
• May reduce inflammation in lung injuries[R]

GW-0742 Safety and Side Effects

Due to its various metabolic properties, GW-0742 has substantial benefits. Preclinical studies demonstrated its potential to improve lipid profiles, glucose homeostasis, and energy expenditure, as well as its anti-inflammatory qualities and vascular advantages. However, long-term animal safety studies are still needed despite promising safety data demonstrating minimal damage to major organs and a low risk of carcinogenicity.

FAQ

What is the half-life of L-Carnitine + Synephrine + SR-9011 + GW-0742?

L-carnitine’s half-life is 9 hours. SR-9011’s half-life is 4-6 hours, GW-0742’s is 3-5 hours, and synephrine is 2-6 hours.

Is Extreme Injectables (L-Carnitine + Synephrine + SR-9011 + GW-0742) safe?

In addition to a lack of consistent evidence of direct benefits, the potential long-term effects of Extreme Injectables L-Carnitine + Synephrine + SR-9011 + GW-0742 are still unknown. Purerawz sells Extreme Injectables for research purposes only, not as dietary supplements. The data presented rely solely on scientific studies for reference purposes only.

Where to Buy Extreme Injectables (L-Carnitine + Synephrine + SR-9011 + GW-0742)Online?

PureRawz is one of the top suppliers of the L-carnitine + synephrine + SR-9011 + GW-0742 in parenteral solution form. If your research requires individual administration, you can also buy L-carnitine, SR-9011, and GW-0742 separately at PureRawz.

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Conclusion

Combining L-carnitine, synephrine, SR-9011, and GW-0742 provides a comprehensive solution for potentially improving physical performance and metabolic health. Each component uniquely contributes to the benefits, including increased fat metabolism, energy, enhanced endurance, and potential anti-inflammatory properties. This shows potential in terms of fat loss and energy utilization.

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