What is 9-Me-BC?

9-Me-BC is a derivative of β-Carboline (BC) and has a half-life of around 15-24 hours. β-Carbolines are naturally-occurring, plant-derived alkaloids found in various fruits, fish, and beef. They have also been detected in the human brain, blood, and cerebrospinal fluid. [R]

9-Me-BC is a known inhibitor of monoamine oxidase A and monoamine oxidase B. These two enzymes remove the neurotransmitters norepinephrine, dopamine, and serotonin from the brain. 9-Me-BC potentially prevents this from happening and may thus elevate mood. [R]

The research chemical has also demonstrated the potential ability to elevate hippocampal dopamine levels, increase dendrite outgrowth, and improve spatial learning performance in vivo. Furthermore, in an animal model of Parkinson’s, 9-Me-BC demonstrated restorative effects. [R][R]

How does 9-Me-BC Work?

Although its exact mechanism remains unknown, various studies have revealed multiple actions of 9-Me-BC, including inhibition of monoamine oxidase A and B, potentially elevating levels of various brain chemicals, and reducing the action of inflammatory cytokines in the brain. [R][R]

In vivo, it has exhibited the potential ability to induce growth of hippocampal dopaminergic neurons, increase dendrite outgrowth, and improve spatial learning performance in vivo.

Furthermore, in an animal model of Parkinson’s, 9-Me-BC demonstrated restorative effects. [R]

9-Me-BC Research

What follows is a summary of the existing clinical, animal and cell-based research on 9-Me-BC. The information in this section is for educational purposes only and does not constitute medical advice. All clinical research must be conducted with oversight of appropriate institutional review board.

1) 9-Me-BC and Parkinson’s disease

In an animal model of Parkinson’s disease, 9-Me-BC showed potential restorative effects. Findings from the study reveal that 9-Me-BC treatment may have potentially improved the expression and transcription of neurotrophin-related genes (BDNF, dopamine, cerebellin). These genes levels drop in people with Parkinson’s. [R]

Additionally, in another animal study, it was found that 9-Me-BC may stimulate, regenerate and protect dopaminergic neurons. Also in this study, the nootropic inhibited monoamine oxidase A and B, highlighting its potential role as a new compound for the treatment of PD. [R]

2) 9-Me-BC and Cognitive Enhancement

According to an animal study, 9-Me-BC treatment may potentially enhance cognitive function in hippocampus-dependent tasks. Researchers conducting this study claimed that elevation in hippocampal dopamine levels and dendritic and synaptic proliferation might be behind this effect. [R]

It was noted that the improvement in the mice’s spatial learning (an important indicator of cognitive function) was most likely caused by enhanced dopamine levels. This shows that there is likely a relationship between enhanced dopamine levels and improved spatial learning.

3) 9-Me-BC and Neuroprotection

A cell-based study found 9-Me-BC may exhibit many neuroprotective actions. Cells treated with this substance experienced inhibited release of lactate dehydrogenase, increased ATP content, and reduced expression of inflammation-related genes. [R]

In another study, 9-Me-BC inhibited the activity of both monoamine oxidase enzymes (MOA-A and MOA-B). The inhibition of these enzymes might be behind 9-Me-BC’s ability to increase dopamine content and inhibit apoptotic properties in cell culture. [R]

4) 9-Me-BC and Inflammation

According to a cell-based study, 9-Me-BC treatment is capable of potentially preventing microglia proliferation induced by toxin treatment. The cognitive enhancer was found to potentially install an anti-inflammatory environment by decreasing the expression of inflammatory cytokines and receptors. [R]

Findings from another study revealed that 9-Me-BC reduced the expression of inflammation-related genes like Vcam1, Tnf, Irf1, and others. In addition to potentially inducing inflammation, these genes are also relevant for apoptosis or programmed cell death. [R]

5) 9-Me-BC and Mitochondrial Respiratory Chain

The mitochondrial respiratory chain (MRC) catalyzes the oxidation of fuel molecules into ATP. It is much more efficient than energy generation by other processes such as glycolysis. Dysfunction of the respiratory chain increases the production of toxic reactive oxygen species (ROS). [R]

Preclinical research has shown that 9-Me-BC may improve the mitochondrial respiratory chain, thereby leading to improved ATP production and bodily functions. However, more clinical studies are needed to fully understand 9-Me-BC’s effects on MRC.

Frequently Asked Questions

What is the half-life of 9-Me-BC?

9-Me-BC appears to have a half-life of 16 – 24 hours.

Is 9-Me-BC?

9-Me-BC isn’t approved for human consumption by the FDA. Pure Rawz sells this research chemical for laboratory and research purposes only.

Where to Buy 9-Me-BC?

Pure Rawz is the best place to buy 9-Me-BC online.

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9-Me-BC Summary

Taken together, the above mentioned research suggests that 9-Me-Bc may potentially exert neuro-protective, neuro-stimulative and neuro-regenerative effects. The nootropic boosts dopamine synthesis and may be a potential candidate for various neurodegenerative disorders like Parkinson’s.