ARA-290

Description

ARA-290 Overview

ARA-290 is an 11-amino-acid peptide derived from the beta domain of the erythropoietin protein. This peptide fragment has been investigated in research models for its involvement in cellular protection and structural maintenance pathways.

Preclinical investigations have suggested that ARA-290 may influence endothelial colony-forming cells (ECFCs) within controlled laboratory models. It has also been studied for its interactions with innate cellular defense pathways and microbial-associated signaling mechanisms in experimental research conditions.

Chemical Properties of ARA 290

Property	Information
CAS Number	1208243-50-8
Molecular Formula	C51H84N16O21
Molecular Mass	1257.31 g/mol
Synonyms	Cibinetide, ARA290, PH-BSP, ARA-290, ARA 290, pHBSP peptide
IUPAC Name	(4S)-5-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-5-oxo-4-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoic acid
Storage	2-8°C (36-46°F)

How Does ARA-290 Peptide Work?

ARA-290 is an 11-amino-acid peptide fragment that is derived from the β-helix region of erythropoietin. It is being investigated in experimental systems for its interaction with the innate repair receptor (IRR). The IRR is a heteromeric receptor complex composed of the erythropoietin receptor and the β-common receptor.

Binding to this receptor complex is proposed to initiate intracellular signaling cascades in research preclinical models. This includes pathways associated with JAK2-mediated signal transduction, which may influence inflammatory signaling modulation and maintenance of cellular integrity.

Research Findings on ARA-290

ARA-290 and Neuropathic Pain Modulation

Experimental research investigating ARA-290 in nerve-injury models reported that the peptide reduced mechanical and cold allodynia in models. The study also showed that ARA-290 suppressed activation of spinal microglia, which are immune cells involved in neuroinflammation and chronic pain signaling.

ARA-290 and Oxidative Stress Protection in Cellular Models

Cell-based research examining ARA-290 found that the peptide reduced oxidative stress and DNA damage caused by doxorubicin exposure. The study suggested that ARA-290 may activate protective cellular pathways linked to the erythropoietin-derived innate repair receptor without stimulating erythropoiesis. These results highlight the peptide's potential role in cytoprotective mechanisms during experimental investigations.

Where to buy ARA-290 for research purposes?

Researchers look for specialized suppliers that focus on high-quality research compounds. PureRawz offers ARA-290 for laboratory and investigative use. We prioritize consistent sourcing and quality control to support scientific studies.

All products are supported with detailed documentation, including reference materials and an independent third-party Certificate of Analysis (COA). This certificate confirms essential parameters such as compound identity, purity level, and concentration. This allows researchers to verify material quality before using it in experimental applications.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.

All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

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Reference Links

PubChem. (2026). Cibinetide. Nih.gov; PubChem. https://pubchem.ncbi.nlm.nih.gov/compound/Cibinetide

Swartjes, M., van Velzen, M., Niesters, M., Aarts, L., Brines, M., Dunne, A., Cerami, A., & Dahan, A. (2014). ARA 290, a peptide derived from the tertiary structure of erythropoietin, produces long-term relief of neuropathic pain coupled with suppression of the spinal microglia response. Molecular Pain, 10, 13. https://doi.org/10.1186/1744-8069-10-13

Shokrzadeh, M., Etebari, M., & Ghassemi-Barghi, N. (2020). An engineered non-erythropoietic erythropoietin-derived peptide, ARA290, attenuates doxorubicin-induced genotoxicity and oxidative stress. Toxicology in Vitro: An International Journal Published in Association with BIBRA, 66, 104864. https://doi.org/10.1016/j.tiv.2020.104864