YK-11 (Myostine) – Product Details
A recent study has shown that YK-11, a selective androgen receptor myostatin inhibitor, accelerates the expression of Follistatin in mice.
Follistatin is a myostatin and activin-binding protein naturally found in the human body and has been used as a treatment for several degenerative muscle diseases. When follistatin levels are raised, myostatin levels will be inhibited. Inhibition of myostatin results in increased muscle mass and improved strength.
This study revealed that mice with low levels of myostatin have twice the amount of muscle mass compared to mice with high levels of myostatin. This shows the massive potential research implications of the strong anabolic effects that YK-11 can possess
|Molar Mass||430.541 g·mol−1|
|IUPAC Name||methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2′-methoxy-2′,13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5′-1,3-dioxolane]-4′-ylidene]acetate|
How Does YK-11 Work?
YK-11 primarily works by inhibiting myostatin. Myostatin is a protein naturally produced by muscle cells in the human body. This protein plays a crucial role in muscle movement and impedes muscle growth and strength, ensuring that muscles do not get too large to inhibit their movement. [R]
A cell study has found that YK-11 inhibits myostatin by raising the levels of follistatin. Follistatin is another naturally occurring protein in the human body. Its elevated levels have been proven to keep myostatin levels in check, helping muscles grow and strengthen. [R] [R]
Is YK-11 A SARM?
YK11 is a selective androgen receptor modulator, but it is also something more. This research compound acts similarly to SARMs in that it binds androgen receptors in the muscle and bone tissue. However, unlike SARMs, it also inhibits myostatin, the naturally occurring protein that impedes muscle growth.
Furthermore, while the majority of SARMs are full agonists of androgen receptors, YK-11 has been found to be a partial agonist. Yet another difference between YK-11 and SARMs is that it is a steroidal compound, whereas most SARMs tend to be non-steroidal.
YK-11 Research Stacks Well With:
While various cell studies have been conducted on YK-11, this steroidal SARM is yet to attract any human or even animal studies. The available clinical data is thus insufficient to claim that it is safe for human consumption. Randomized long-term trials are needed to determine its safety and efficacy.
YK-11 and Muscle Mass
Myostatin is a protein that impedes muscle growth and strengthening.
A cell study has shown that YK-11 attaches to the androgen receptor to help inhibit the production of myostatin in the muscle to create more follistatin, thus, increasing muscle growth. This shows massive promise in the potential anabolic activity of YK-11. [R]
The mechanism with which YK-11 works distinguishes it from other SARMs. Most SARMs work by binding androgen receptors in the muscle and bone tissue. They don’t have anything to do with myostatin or follistatin. YK-11 is thus a novel steroidal SARM.
YK-11 and Bones
In a cell study, YK-11 was found to activate PKB (protein kinase B) in osteoblast cells of mice.
PKB are enzymes naturally found in the human body. Research has shown that, upon, activation, PKBs send signals to stimulate bone growth. They are also proven to play an essential role in glucose metabolism as well as angiogenesis. [R]
However, more extensive research and randomized trials are needed to potentially evaluate its efficacy in strengthening bones in select populations.
YK-11 and Muscle Wasting
Sepsis patients are especially vulnerable to muscle wasting.
To observe the effects of YK-11 on muscle wasting, septic mice were administered Myostatin. YK-11 was found to decrease weight loss in the mice in a concentration-dependent manner. YK-11 also reverted muscle mass loss and muscle cell atrophy and increased total body weight. [R]
Moreover, YK-11 uptake helped recover muscle mass loss in the backs and thighs of mice. Still, longer randomized trials are needed to evaluate its efficacy in select populations.
YK-11 and Fat Loss
A recent study set out to investigate the expression and regulation of myostatin in skeletal muscle in septic mice. The results showed that the YK-11 treatment decreased fat mass. [R]
However, in the absence of any long-term study, it is difficult to verify the effect of YK-11 on fat mass in select populations. Long-term, clinical trials are needed to potentially evaluate its efficacy in reducing body fat.
Is YK-11 Legal in the USA?
YK11 is legal to purchase a research compound.
Like other SARMs, it can be used for laboratory research use only.
Is YK11 A Steroidal Compound?
YK-11 doesn’t belong to the anabolic steroids family. It is a synthetic steroidal SARM that selectively binds androgen receptors in the bone and muscle tissue. Aside from that, YK-11 may also inhibit myostatin, a hormone that impedes rapid muscle growth in animals and humans.
Where to Buy YK-11 Online
PureRawz is the best place to buy YK-11 for sale.
In order to be the best SARMs supplier, we provide reference materials with every product we sell. Each of our SARMS comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.
YK-11 is a synthetic steroidal SARM that may increase muscle mass and enhance bone health, per preliminary cell studies. However, long-term randomized clinical trials are needed to verify its safety and efficacy in random populations.