SR 9011 – Product Information
SR 9011 is a Rev-Erb alpha (Rev-ErbA) agonist.
Rev-ErbA is a nuclear receptor that may potentially regulate the circadian rhythm or the body’s internal 24-hour clock. Plus, it may have the ability to control the body’s metabolism and regulate memory and mood. Research shows that the nuclear receptor also regulates neuro-inflammation. [R]
SR 9011 was initially developed by Professor Thomas Burris of Scripps (formerly the Scripps Research Institute USA). At the time of writing, SR 9011 isn’t approved for human consumption by the FDA. Pure Rawz sells SR 9011 for laboratory research use only.
|Molar Mass||479.04 g·mol−1|
How does SR 9011 Work?
Research has shown that SR 9011 may have the potential to enhance Rev-ErbA activity in the body. A dose-response study confirmed this by showcasing that this research chemical may potentially suppress the expressions of Serpine1, Cyp7a1, and Srebf1, all of which are Rev-ErbA targets. [R]
SR 9011 Research
Various animal studies have been conducted to determine the potential effects of SR 9011. This research chemical has also undergone various cell-based studies. Based on the available data, it can be said that SR 9011 holds immense potential.
SR 9011 and Neuro-inflammatory Diseases
A cell-based study was conducted to determine the potential effect of SR 9011 on the immune response and cell metabolism of the brain’s immune cells. Results from the study established that this research chemical is a potential therapeutic target for the treatment of neuro-inflammatory diseases. [R]
Neuro-inflammatory diseases happen when the immune system – which is designed to protect the body and the brain – becomes overly active and attacks healthy cells. At the time of writing, there is no known cure for these disorders.
SR 9011 and Cancer
An animal study has demonstrated that SR 9011 and SR 9009 may potentially possess anticancer activity. Furthermore, while both these Rev-Erb agonists may be potentially lethal to cancer cells, they have no effect on the viability of normal cells or tissues. Plus, their anticancer properties improved survival in mice. [R]
Together, these results indicate that SR 9011 and SR 9009 target a potentially wide spectrum of tumors are highly selective in their action, and exhibit low toxicity. Thus, both these agonists of REV-ERBs may represent a potentially improved therapeutic strategy for treating cancer.
SR 9011 and Fat Loss & Cholesterol
Chronic administration of SR 9011 to mice resulted in weight loss. Researchers observed that the weight reduction was due to potential decreased fat mass. Aside from that, the mice also experienced reduced production of new fat cells (also known as lipogenesis) in the liver. [R]
Furthermore, the administration of SR 9011 led to decreased production of cholesterol and bile acids in the liver. All these results indicate that SR 9011 may have the potential ability to positively affect the mice’s whole-body metabolism.
SR 9011 and Wakefulness
SR 9011-treated mice developed a large increase in wakefulness that was maintained for 2 hours post-injection, results from an animal study show. The increase in wakefulness remained intact for 12 hours, after which mice recovered their normal sleep pattern. [R]
Based on these results, the researchers conducting the study concluded that the administration of SR 9011 may potentially suppress sleep and stimulates wakefulness. However, the effect is acute or short-lasting, which is consistent with the short half-life of this compound.
SR 9011 and Heart Disease
A mice study was conducted to investigate the effect of SR 9011 and SR 9009 on the progression of myocardial infarction (MI) and heart failure. Both were reported to potentially improve hyperglycemia, dyslipidemia, and skeletal muscle oxidative capacity. [R]
In terms of clinical implications, the present study suggests that Rev-Erb agonists can be a promising novel compound for MI and heart failure.
SR 9011 and Anxiety
In the abovementioned study, the administration of SR 9011 decreased anxiety-like behavior among the mice. Mice treated with SR 9011 spent considerably more time in the center of the field but displayed no change in the total distance traveled. This confirmed the potential anxiolytic effect of this compound.
Where to Buy SR9011 Online?
Pure Rawz is the best place to buy SR 9011 for sale.
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This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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