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Enclomiphene Citrate

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Description

Enclomiphene Citrate – Product Information

Enclomiphene Citrate is a selective estrogen receptor modulator (SERM) that has received extensive attention, widely researched for the treatment of male secondary hypogonadism. This condition is caused by the insufficient production of testosterone within the hypothalamic-pituitary-gonadal (HBG) axis.

Mechanism of Action

In research subjects, enclomiphene citrate functions by blocking the hypothalamus’s estrogen receptors. This reduces the negative feedback on the hypothalamic-pituitary-gonadal (HBG) axis, leading to an increase in the release of FSH and LH.

These hormones have the potential to keep men with hypogonadism fertile by stimulating the testes to produce more testosterone and promoting spermatogenesis.

FSH and LH are essential for healthy male reproduction:

  • Luteinizing Hormone (LH) stimulates the testes to create testosterone, which is necessary for sustaining bone density, muscle mass, libido, and energy levels.
  • Follicle Stimulating Hormone (FSH) promotes spermatogenesis, which is essential for spermatogenesis, which is essential for maintaining normal sperm production within the normal range.

Benefits of Enclomiphene Citrate

  • Potential for Natural Testosterone Production: By boosting the HPG axis, enclomiphene citrate has the potential to produce more testosterone naturally without drawbacks of direct testosterone supplementation, like testicular atrophy or decreased sperm production.
  • Maintains Fertility: Unlike traditional testosterone therapies, which often reduce sperm counts, enclomiphene citrate can potentially help maintain or even improve sperm concentrations, making it suitable for subjects who wish to preserve or enhance their fertility.
  • Potential For Fewer Side Effects: Compared to exogenous testosterone treatments, enclomiphene citrate may have the potential for a lower risk of side effects because it promotes the natural hormone regulating processes.

Enclomiphene Citrate and Hypogonadism

Hypogonadism in adult males is characterized by insufficient testosterone or sperm, or both. Some symptoms of hypogonadism are fatigue, mood swings and a decreased sex drive.

Researchers are looking into enclomiphene citrate as a possible therapy to help men regain their natural testosterone levels while maintaining fertility.

Clinical Research

Enclomiphene citrate has been the subject of numerous clinical studies, particularly focusing on its ability to raise serum testosterone levels while maintaining normal sperm counts in male subjects with secondary hypogonadism. Research has shown that enclomiphene citrate is a potential way to raise testosterone levels without having the typical side effects of standard testosterone.

Summary

Enclomiphene citrate is a promising SERM being researched for the treatment of male secondary hypogonadism. It may in future be potentially a substitute for conventional testosterone replacement therapy since it takes a different approach by encouraging natural production of testosterone while preserving sperm production.

While enclomiphene citrate is still being studied and is not yet licensed for general clinical use, it is a major development in the treatment of low testosterone and male infertility.

What is enclomiphene citrate researched for?

Enclomiphene citrate is primarily being researched used to treat male subjects with chronically low testosterone levels caused by secondary hypogonadism. In this condition, low testosterone levels are due to the dysfunction in the hypothalamic pituitary gonadal (HPG) axis.

Is enclomiphene good for testosterone?

Enclomiphene citrate may have the potential to be effective at raising testosterone levels in male subjects with hypogonadism while also preserving sperm counts.

Is enclomiphene good for fertility?

Enclomiphene is a selective estrogen receptor modulator ( SERM) that has the potential to boost testosterone production, making it a potential future effective treatment for male infertility and secondary hypogonadism.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

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