White Royal Borneo Kratom – Product Information
Mitragynine Content Grade A+ : >2%.
Kratom leaves are well-known for varying different colors. The difference between these colors lies in the different kratom strains and the age of the plant which may change the proposed effects. Sometimes, the way kratom leaves are dried and/or processed impacts the color or strain, but the major distinction lies in the age of the leaves when harvested.
White vein kratom is the youngest plant, green vein kratom is a slightly more mature plant, and red vein kratom is a fully mature plant. As a kratom plant matures, different levels of stimulant alkaloids build within its leaves. The different alkaloids determine what effect the kratom will have and also give the veins their unique properties.
White Royal Borneo is a traditional herb collected from the larger island of Borneo. White Borneo is termed after the white vein that runs down the middle of the inside of the leaf. White Borneo Kratom is being researched for its proposed benefits and is mostly recognized as potentially having similar effects to that of coffee.
More research into White Borneo Kratom can potentially advocate for its use in improving concentration, endurance, relaxation, performance, and numerous other qualities.
|Molar Mass||398,4953 g/mol-1|
|IUPAC Name||methyl 2-(3-ethyl-8-methoxy-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-2-yl)-3-methoxyprop-2-enoate|
What is White Royal Borneo Kratom?
White Borneo Kratom is a type of kratom that is derived from the leaves of the Mitragyna Speciosa tree, an evergreen tree in the coffee (Rubiaceae) family native which is native to Southeast Asia. It is named after the Borneo island where it is primarily grown. [R]
Since at least the 19th century, Kratom strains have been utilized in herbal medicine. [R] Kratom leaves can have different colors depending on their maturity and the specific strain of the plant. Generally, there are three main colors of kratom: red, green, and white. Red kratom is typically made from mature leaves and is known for its relaxing and pain-relieving effects. Green kratom is made from leaves that are slightly less mature than those used for red kratom. It is said to have a potential balance of energizing and relaxing effects, making it a popular choice for researchers who want to investigate how to manage pain and increase productivity without feeling overly stimulated or sedated while white kratom is made from the youngest leaves and is known for its energizing effects. It is often used by researchers who want to improve focus, motivation, and productivity. [R]
White vein kratom or white vein strains are the youngest plant, green vein kratom is a slightly more mature plant, and red vein kratom is a fully mature plant. As a kratom plant matures, different levels of stimulant alkaloid build within its leaves. The different alkaloids determine what effect the kratom will have and also give the veins their unique properties.
Kratom contains about 45 alkaloids, according to Ramanathan et al. [R] It typically contains alkaloids such as mitragynine, 7-hydroxymitragynine, paynantheine, speciociliatine, and speciogynine. White kratom may also contain the alkaloids corynantheidine, mitraphylline, and raubasine. The precise makeup of these alkaloids might change based on the kratom strain and how it is grown and processed. [R]
The most prevalent alkaloid in kratom, mitragynine, is in charge of many of the substance’s effects. It has been demonstrated to interact with a number of brain receptors, including mu-opioid, delta-opioid, and adenosine receptors, and has both stimulant and analgesic characteristics. The alkaloid 7-hydroxymitragynine is regarded to be stronger than mitragynine. It has similar effects to mitragynine on the brain’s opioid receptors, but it also has modest activity at serotonin receptors. Paynantheine has been demonstrated that this alkaloid possesses potential anti-inflammatory and muscle-relaxing actions. Speciociliatine alkaloid resembles mitragynine in terms of structure but has less potent effects and speciogynine is an alkaloid that has been proven to have some calming and modest pain-relieving effects. White kratom may also contain the alkaloids corynantheidine, mitraphylline, and raubasine. The precise makeup of these alkaloids might change based on the kratom strain and how it is grown and processed. [R]
How Does White Royal Borneo Kratom Work?
The effects of white vein borneo kratom can vary depending on the dosage, with lower doses producing a more stimulating effect and higher doses having a more sedative effect.
With mitragynine and 7-hydroxymitragynine being the most well-known and studied, both of these alkaloids are partial agonists of the μ-opioid receptor and competitive antagonists of the δ-opioid receptor, meaning that they have some similarities to traditional opioids but also some differences. [R]
Opioid receptors are specialized receptors in the brain and body that opioids bind to in order to act. Opioid receptors come in a variety of forms, such as mu, delta, and kappa receptors. Pain alleviation, sedation, and sensations of pleasure or euphoria are just a few of the effects that result from an opioid medication binding to these receptors. Opioids work by imitating endorphins and other naturally occurring substances in the body that reduce pain. They boost the brain’s production of these chemicals, which lessens the sense of pain. Opioids, however, also have an impact on the digestive and respiratory systems as well as other bodily systems. Opioids frequently lead to euphoria or relaxation in addition to pain relief, which is why they are misused so frequently. [R]
Unlike the two alkaloids present in White Kratom, they do not activate the β-arrestin pathway, which is responsible for some of the negative side effects of opioids such as respiratory depression, constipation, and sedation. [R]
In addition to their effects on opioid receptors, mitragynine, and 7-hydroxymitragynine also interact with other receptors in the brain, including serotonin and dopamine receptors. Mitragynine has been shown to inhibit COX-2 and block calcium channels, and it stimulates α2-adrenergic receptors, which can lead to sedation. [R]
Kratom is metabolized in humans via phase I and phase II mechanisms, with the resulting metabolites excreted in the urine. Kratom extracts have been shown to inhibit several enzymes involved in drug metabolism, which can increase the risk of drug interactions. [R]
White Royal Borneo Kratom Research
Numerous studies have been conducted on the potential application of White Borneo Kratom powder. Below are some of the relevant findings:
White Borneo Kratom on Pain Relief/Management
A study evaluated the pain-relieving effects of kratom in a randomized, placebo-controlled, double-blind study. The results showed that pain tolerance increased significantly one hour after kratom ingestion, but was unchanged after consuming placebo drinks. No discomfort or signs of withdrawal were reported or observed during kratom discontinuation. The study suggests that kratom has potential as a pain reliever, but further research on its safety profile is needed. [R]
The University of Florida conducted a study on lyophilized kratom tea (LKT). The study found that LKT produced significant pain-relieving effects in animal models, and these effects were shown to originate from interactions with mu-opioid receptors found in cells throughout the central nervous system. [R]
Additionally, the essential structural features of mitragynine responsible for the analgesic activity were elucidated, and 7-hydroxymitragynine, a minor constituent of M. speciosa, was found to exhibit potent antinociceptive activity in mice. [R]
White Borneo Kratom as Muscle Relaxant
A study aimed to investigate the effects of mitragynine and a methanolic extract of kratom leaves on neuromuscular junction and compound nerve action potential. The results showed that the kratom extract and mitragynine decreased muscle twitch, and the muscle relaxation caused by kratom extract was greater than that of mitragynine. Additionally, high concentrations of kratom extract and mitragynine blocked nerve conduction, amplitude, and duration of compound nerve action potential. The study suggested that kratom extract might not act as a competitive antagonist of acetylcholine and its dominant effect was at the neuromuscular junction. [R]
White Borneo Kratom as an Anti-inflammatory
The study aimed to investigate the anti-inflammatory and antinociceptive activities of the methanol extract of Mitragyna speciosa in rodents. The extract was tested using various tests, including the carrageenan-induced paw edema and cotton pellet-induced granuloma tests in rats, the writhing test, the hot plate test, and the formalin test in mice and rats. The results showed that the extract had significant dose-dependent activity in all nociceptive models tested and significantly suppressed the development of carrageenan-induced rat paw edema. The extract exhibited potent antinociceptive and anti-inflammatory properties, supporting its traditional on such conditions. [R]
White Borneo Kratom on Mental Health
In a survey, 67% out of 2,798 of the test subjects predominantly used Kratom for anxiety. [R] Meanwhile, a case study describes a 63-year-old test subject who had been using Kratom for 7 years to manage persistent major depression and anxiety disorder. However, during the COVID-19 pandemic and increased stress at work, the established Kratom doses failed to control the test subject’s symptoms. The patient sought treatment and was subsequently detoxified from Kratom. His anxiety and depression management was shifted to treatment with medication and psychotherapy. [R]
A study evaluated the antidepressant effect of mitragynine, the major active alkaloid in Mitragyna speciosa leaves, in mice using the forced swim test (FST) and tail suspension test (TST) which are predictive models of antidepressant activity. The study also measured the effect of mitragynine on the neuroendocrine system of the hypothalamic-pituitary-adrenal (HPA) axis by measuring the corticosterone concentration of mice exposed to FST and TST. The study concludes that mitragynine exerts an antidepressant effect in animal behavioral models of depression, and this effect appears to be mediated by an interaction with neuroendocrine HPA axis systems. However, further research is required to understand the precise mechanism of action of mitragynine and its potential applications in depression. [R]
Another study investigated the effects of Mitragyna speciosa (MS) extract, containing approximately 60% mitragynine, on the dorsal raphe nucleus and its potential antidepressant-like activity. The study used male Wistar rats to detect the expression of the immediate early gene, cfos, in the dorsal raphe nucleus to determine the stimulatory effect of the MS extract. The results showed a significant increase in Fos expression after long-term administration of the MS extract (40 mg/kg) for 60 consecutive days. The study also used the forced swimming test (FST) in male mice to determine the antidepressant-like activity of the MS extract. A single injection of either 60 or 90 mg/kg doses significantly decreased immobility time in the FST. These results suggest that the MS extract has a stimulatory effect on the dorsal raphe nucleus and potential antidepressant-like activity. Furthermore, the findings suggest that the MS extract might produce antinociceptive and/or antidepressive actions, in part, through activation of the dorsal raphe nucleus. [R]
A study investigated the potential antipsychotic-like effects of methanolic extract of Mitragyna speciosa leaf (MMS) using both in vivo and ex vivo studies. In vivo, studies used apomorphine-induced climbing behavior, haloperidol-induced catalepsy, and ketamine-induced social withdrawal tests in mice. The ex vivo study was conducted using an isolated rat vas deferens preparation. Overall, the findings suggest that MMS may have antipsychotic-like activity and may have the potential to alleviate both positive and negative symptoms of psychosis in mice. [R]
White Borneo Kratom on Cancer (Pain Management)
Chemotherapy-induced peripheral neuropathy (CIPN), which is brought on by injury to the peripheral nerve system, is a complex and severe chronic pain disease linked to chemotherapy exposure. It is characterized by signs and symptoms that mostly affect the hands and feet, including atypical and spontaneous pain, hyperalgesia, allodynia, heat hypersensitivity, numbness, and tingling. Mitragynine (MG) is an alkaloid found in Mitragyna speciosa (kratom) that is used as an herbal remedy for pain relief and opioid withdrawal. The purpose of this study was to characterize the effects of MG in a mouse model of chemotherapy-induced peripheral neuropathy (CIPN) and to investigate the potential impact of sex on MG’s efficacy. The study found that MG was effective in attenuating mechanical allodynia induced by oxaliplatin, and its effects were mediated by activity at µ-opioid, α1- and α2-adrenergic receptors. The study also found that MG was more potent in males vs females, and the highest dose of MG (10 mg/kg) exhibited greater anti-allodynic efficacy in males. [R]
White Borneo Kratom on Ethanol/Morphine Withdrawal
The influence of G protein-biased agonists of μ-opioid receptors on addiction-related behaviors has also been studied for alkaloids present in Kratom. [R]
Two animal studies examined the effect of orally administered kratom on reducing ethanol withdrawal symptoms compared to fluoxetine. Both studies found that the alkaloid fraction of kratom had a similar effect as fluoxetine in reducing locomotor hyperactivity. Additionally, while fluoxetine suppresses REM sleep, kratom did not affect any REM parameters following oral administration. [R][R]
Additionally, in a study by the University of Florida on lyophilized kratom tea (LKT). Kratom has shown potential benefits for opioid withdrawal, which is a severe condition resulting from opioid dependence. In animal models, even low doses of lyophilized kratom tea (LKT) significantly reduced withdrawal symptoms and did not show the side effects associated with current medications. [R]
White Borneo Kratom as Anthelmintic
The study aimed to determine the anthelmintic properties of mitragynine, the major alkaloid in Mitragyna speciosa, against L3 stage larvae of strongyles in goats. The study found that mitragynine exhibited dose-dependent anthelmintic activity with the most effective and lowest effective concentrations being 0.4 and 0.2 mg/mL, respectively, within 24 hours of trial. The study suggests that mitragynine could potentially be used as an anthelmintic for caprine strongyles. [R]
White Borneo Kratom as Antipyretic
One study aimed to investigate the antipyretic properties of the crude methanolic extract of Mitragyna speciosa and determine its effective dose against Brewer’s yeast-induced pyrexia in mice. The results showed that all groups treated with the crude methanolic extracts of Mitragyna speciosa produced a significant reduction of rectal temperature compared to the negative control group. The antipyretic effective dose of the extract was found to be 100 mg/kg, and it exhibited dose-dependent antipyretic properties in mice. [R]
Is White Royal Borneo Kratom safe?
In addition to a lack of consistent evidence of direct benefits, the potential long-term effects of using White Borneo Kratom daily are also unknown. Purerawz sells White Borneo Kratom for research purposes(lab supply) only.
Where to Buy White Royal Borneo Kratom Online
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