HGH Fragment 176-191 – Product Information
Human growth hormone (HGH) fragment 176-191 is synthesized from the C-terminus of HGH. In mice, long-term administration of HGH 176-191 induced weight loss and increased lipolytic (fat-burning) sensitivity. HGH 176-191 is thus known as the “lipolytic fragment” of HGH. [R]
HGH 176-191 has also been shown to decrease body weight. Furthermore, a mice study demonstrated that this synthetic HGH fragment increases blood glucose levels. HGH 176-191 has also helped promote cartilage healing in animal studies. [R][R]
|HGH Fragment 176-191|
|Molar Mass||848.9 g/mol-1|
|IUPAC Name||(2S)-6-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]hexanoic acid|
What is HGH Fragment 176-191?
HGH 176-191 is a synthetic analog of human growth hormone. It is a synthetic peptide with 16 amino acids in its chain. HGH 176-191 is sometimes referred to as the “lipolytic fragment” of HGH. This is because of research showing that it could potentially induce fat loss in animals. [R]
In animal studies, HGH 176-191 has shown potential as an anti-obesity agent. More promisingly, a cell-based study has demonstrated that this modified form of HGH enhances the anti-cancer potency of compounds targeting breast cancer cells. [R]
HGH Fragment 176-191 Vs HGH
Although HGH 176-191 is derived from the C-terminal sequence of human GH, there are several differences between the unmodified growth hormone and its fragment.
HGH 176-191, for instance, doesn’t induce diabetes. Neither does this HGH fragment increase IGF-1 levels. Higher than normal levels of IGF-1 may cause gigantism in children or acromegaly in adults. Gigantism and acromegaly are consequences of having too much HGH. [R][R]
Additionally, studies showed that GH treatment of both healthy and GH-deficient subjects decreases whole-body carbohydrate oxidation. However, research has indicated that HGH 176-191 doesn’t influence carbohydrate metabolism in the body. [R][R]
HGH Fragment 176-191 Research
Various animal and cell-based studies have been conducted on HGH Fragment 176-191. These studies have shown that the synthetic peptide may have the ability to induce lipolytic action, inhibits lipogenesis, and enhances the toxicity of compounds targeting cancer particles in the breast cancer line.
HGH Fragment 176-191 has also been shown to produce a short-lived rise in blood glucose and a more sustained rise in plasma insulin in mice. Aside from that, this research chemical has demonstrated potential weight reduction and fat reduction effects.
HGH 176-191 and Fat Loss
Results from an animal study show that 14-day administration of HGH Fragment 176-191 reduced body weight and body fat in obese mice. Researchers conducting the study noted that this synthetic peptide induced fat loss by increasing energy expenditure and fat oxidation. [R]
In another study, daily treatment with an oral dose of HGH 176-191 increased lipolytic activity in the adipose tissues of the treated mice. Furthermore, HGH 176-191 treatment showed no adverse effect on the animals’ insulin sensitivity. [R]
HGH 176-191 and Obesity
An animal study has found that daily treatment with an oral dose of HGH 176-191 reduced over 50% of the body weight gain of the animals in comparison with the control. The results demonstrate that this synthetic peptide has the potential to be a safe therapeutic agent for obesity. [R]
In another mouse study, chronic treatment with HGH or its HGH 176-191 increased obese fat cell oxidation and weight loss. Unlike HGH, this fragment didn’t induce hyperglycemia. Nor did it reduce insulin secretion or competed for the HGH receptors. [R]
HGH 176-191 and Breast Cancer
A cell-based study has demonstrated that HGH Fragment 176-191 enhances the toxicity of compounds targeting cancer cells in the breast cancer line. Chitosan nanoparticles loaded with HGH 176-191 demonstrated potential enhanced cytotoxic efficacy against breast cancer cells. [R]
Moreover, the inclusion of HGH 176-191 may promote the inclusion of nanoparticles in tumors while reducing non-target tissue exposure. This, in turn, may enhance therapeutic efficiency and reduce the adverse effects of this anti-cancer compound.
HGH 176-191 and Osteoarthritis
A 2016 study found that hyaluronic acid administration loaded with HGH 176-191 was more effective than either HA or this HGH frag administration alone in a rabbit osteoarthritis model. It was also found that intra-articular HGH Fragment 176-191 administration enhanced cartilage regeneration.
Furthermore, it was noted that osteoarthritic rabbits administered HGH 176-191 injections had less morphological and histopathological damage than the control group. [R]
Where to Buy HGH 176-191 Online?
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HGH Fragment 176-191 has demonstrated the potential ability to decrease fat accumulation by enhancing lipid breakdown and fat metabolism in mice. This synthetic HGH fragment may also potentially induce weight loss, increase the efficacy of anti-cancer compounds and enhance cartilage regeneration.
Pure Rawz sells HGH 176-191 for research purposes only.