Gonads (Arimistane + Enclomiphene) – Product Information
Gonads is a research compound designed to facilitate researchers investigating post-cycle therapy (PCT). Formulated with Arimistane and Enclomiphene, Gonads aim to support hormone balance and recovery after a cycle of hormonal treatment in research subjects.
Arimistane may help mitigate potential estrogen-related issues, while Enclomiphene may support the restoration of natural testosterone production. This comprehensive approach may aid in optimizing hormonal levels, reducing the risk of estrogenic side effects, and facilitating the post-cycle period in research studies.
- Gonads liquid and tablets consist of two compounds: Arimistane + Enclomiphene.
- Gonads tablets are offered as 50mg Arimistane + 20mg Enclomiphene per tablet.
- Gonads liquid are offered as 16,5mg Arimistane + 16.5mg Enclomiphene per liquid vial.
Arimistane is an aromatase inhibitor, which implies a reduction in the production of estrogen. Aromatase inactivators are bound to the catalytic site, where they are transformed into electrophilic intermediates that become irreversibly attached to the enzyme, blocking its activity. These inhibitors have distinct advantages in compound design because they are highly enzyme-specific, produce prolonged inhibition, and exhibit minimal toxicities. Studies show that Arimistane as an aromatase inhibitor effectively delays epiphysial maturation in young subjects and improves testosterone levels in adult subjects, by suppressing the production of estrogen.
Enclomiphene is an estrogen receptor (ER) modulator. It acts as an ER antagonist in human subjects, sheep, and rabbits and an ER agonist in rats. Enclomiphene inhibits the binding of 17beta-estradiol in isolated rabbit uterus. It decreases E2-induced inhibition of follicle-stimulating hormone (FSH) secretion in primary sheep pituitary cells in a concentration-dependent manner. Enclomiphene (0.25 and 0.5 mg/animal) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats. Formulations containing enclomiphene have been used in the treatment of ovarian dysfunction. Enclomiphene is being studied for its potential to increase serum total testosterone levels while maintaining sperm counts in the normal range, in male subjects with secondary hypogonadism.
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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