Description

What is Nephilim’D Transdermal (S-23 + YK-11 + LGD-4033 + 5a Hydroxy Laxogenin)?

Combining S-23, YK-11, LGD-4033, and 5a Hydroxy Laxogenin, Nephilim’D Transdermal is intended to improve muscular mass, strength, endurance, and recuperation. Because androgen receptors (AR) are widely distributed throughout the body, this combined-formula combines the actions of selective androgen receptor modulators (SARMs) with the protein synthesis-enhancing qualities of 5a Hydroxy Laxogenin, addressing a wider range of tissue targets.

Potential Benefits of the Combined Formula

1. SARMs (S-23, YK-11, and LGD-4033) and 5a Hydroxy Laxogenin may potentially boost protein synthesis and muscle growth.
2. Each component may boosts strength and endurance, making this combined-formula ideal for resistance and endurance training.
3. S-23 and LGD-4033 may aid fat loss
4. 5a Hydroxy Laxogenin may minimize muscular fatigue and improve recovery.

What are Selective Androgen Receptor Modulators (SARMs)?

S-23[R]
CAS	1010396-29-8
Molar Mass	416.8 g/mol
Chemical Formula	C18H13ClF4N2O3
IUPAC Name	(2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

How does S-23 work?

S-23 functions as a selective androgen receptor modulator (SARM) by binding to androgen receptors in the body, maximising anabolic activity in muscle and bone tissue and reducing androgenic effects in other tissues. The S-23 complex translocates to the cell nucleus after binding to the androgen receptor, where it recruits several cofactors and co-regulatory proteins to control gene expression [R].

S-23 may cure muscle wasting and osteoporosis by boosting muscle mass and bone density. Tissue-selective anabolic treatment may have fewer negative effects than standard steroids.

S23 Investigations

• Potentially aids in fat loss by promoting lean muscle mass and male contraceptive [R]

Safety and Side Effects

The side effects of S-23 include testosterone suppression, which can necessitate post-cycle therapy (Post-Research Recovery Protocol) to restore natural hormone levels. Other potential side effects include mood swings, liver toxicity, and changes in lipid profiles [R], although comprehensive long-term safety data are lacking due to limited human studies.

YK-11[R]
CAS	51370003-76-1
Molar M	430.534 g/mol
Chemical Formula	C27H42O5
IUPAC Name	(1S,2S,4S,5’R,6R,7S,8R,9S,12S,13R,16S,18R)-16,18-dihydroxy-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2′-oxane]-19-one

How does YK11 work?

A androgen receptor (AR) partial agonist YK11 activates AR without a N/C interaction and significantly enhances essential myogenic regulatory factors (MRFs) in muscle tissue, promoting anabolic activity. It increases the levels of follistatin, a protein that suppresses myostatin. Myostatin is a growth factor that controls muscle growth; therefore, blocking it with YK-11 may lead to enhanced muscular development [R].

YK-11 acts as a partial androgen receptor (AR) agonist by increasing follistatin (FST) synthesis and targeting certain genes, such as myostatin (GDF8), thus increasing its ability to promote muscle growth and bone tissue development. YK-11’s myogenic actions entail NF-κB signaling, which has been shown to reduce muscle wasting during sepsis [R].

YK-11 Investigations

• Potential treatment of osteoporosis [R]
• Stimulates muscle growth while inhibiting myostatin[R]
• Promotes significant muscle hypertrophy that reverts muscle wasting during sepsis recovery and subdues the inflammatory environment [R].

Safety and Side Effects

YK-11 has yet to be tested in human clinical trials. However, its strong anabolic effects might also lead to severe hormonal imbalances visible in some test subjects [R].

LGD-4033 (Ligandrol)[R]
CAS	1165910-22-4
Molar Mass	338.25 g/mol
Chemical Formula	C14H12F6N2O
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

How does LGD-4033 (Ligandrol) work?

The actions of androgen are mimicked by LGD-4033, although it does not have the unfavorable side effects on the skin or prostate. Because of its selectivity, it is a desirable choice for studies looking for less risky anabolic advantages. Additionally, in experiments conducted on animals, it showed strong selectivity for muscle over prostate and anabolic and anti-resorptive effects in bone [R].

Drug Investigations:

• Increases lean muscle mass [R].
• May improve osteoporotic bones [R],[R].
• Potential anabolic therapies for muscle loss associated with aging, illness, or specific conditions like cancer, cachexia, and osteoporosis, paving the way for longer-term efficacy trials in older test subjects [R].

Safety and Side Effects

Clinical trials suggest that LGD-4033 is generally well tolerated. It has a favorable pharmacokinetic profile and improved lean body mass, despite a brief period of no significant change in prostate-specific antigen levels. However, higher doses or long-term use may result in a reduction in natural testosterone production, necessitating Post-Research Recovery Protocol[R].

What is 5α-hydroxy-laxogenin?

5α-hydroxy-laxogenin  [R]
CAS	56786-63-1
Molar M	446.6 g/mol
Chemical Formula	C27H42O5
IUPAC Name	(1S,2S,4S,5’R,6R,7S,8R,9S,12S,13R,16S,18R)-16,18-dihydroxy-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2′-oxane]-19-one

5α-hydroxylaxogenin is a synthetic derivative of a naturally occurring spirostane-type steroid, laxogenin that shows androgenic potential. However, there is currently no solid evidence supporting the anabolic or androgenic activity of 5α-hydroxy-laxogenin [R].

How it works

In recent research, two in vitro bioassays were conducted to examine its androgenic potential. In human prostate cells, 5α-hydroxy-laxogenin transactivated the androgen receptor in a dose-dependent manner in both situations. It is interesting to note that at higher doses, it had agonistic effects but antagonistic properties at lower ones. These results imply that higher dosages of 5α-hydroxy-laxogenin might have androgenic properties, but more research is still needed to determine its safety and potential anabolic advantages [R].

5α-hydroxy-laxogenin Investigations

• Possible anticancer activity in a two-stage lung carcinogenesis research. [R] [R].
• Potential to neutralize oxidative stress [R]
• May contribute in muscle growth. [R]

Safety and Side Effects

Though 5α-Hydroxy Laxogenin is advertised as an anabolic agent in dietary supplements, research evidence supporting its effects remains inadequate. The observed androgenic activity in human cells at greater concentrations suggests potential anabolic effects, but it also highlights the need for additional research to fully understand the risks and benefits.

FAQ

Is S-23 + YK-11 +LGD-4033+5a Hydroxy Laxogenin safe?

In addition to a lack of consistent evidence of direct benefits, the potential long-term effects of using S-23 + YK-11 +LGD-4033+5a Hydroxy Laxogenin Combined Formula are also unknown. Purerawz sells Nephilim’D Transdermal Combined Formula for research purposes only, not as dietary supplements or body-building supplements. The data presented rely solely on scientific studies that are for reference purposes only and not to be taken as dietary supplements.

Where to Buy S-23 + YK-11 + LGD-4033 + 5a Hydroxy Laxogenin Combined Formula Online?

PureRawz is one of the top suppliers of Nephilim’D Transdermal (S-23 + YK-11 + LGD-4033 + 5a Hydroxy Laxogenin) in liquid form. You can also buy S-23 , YK-11, LGD-4033 , 5a Hydroxy Laxogenin separately at PureRawz if you research requires individual administration.

To produce a quality item, we carry the item’s reference materials with every product we sell. Each of our compounds sold comes with an independent, third-party-issued Certificate of Analysis for identification, purity or concentrated natural extract, and concentration. PureRawz doesn’t sell modified items.

If you are looking for the best place to buy Nephilim’D Transdermal (S-23 + YK-11 + LGD-4033 + 5a Hydroxy Laxogenin) near you, we offer free shipping in the USA and worldwide on all orders or items above $100. You can pay for your purchase using various methods, including a PayPal account and Bitcoin. Click on the ‘Reviews’ tab to check what existing customers say about our products and excellent customer service.

Conclusion

S-23, YK-11, LGD-4033, and 5a Hydroxy Laxogenin are a combined-formula of multicomponent SARMs that have the ability to optimize physical performance, strength, and muscle growth. Purerawz sells the Nephilim’D Transdermal (S-23 + YK-11 + LGD-4033 + 5a Hydroxy Laxogenin) exclusively for research purposes. To further reduce the potential for adverse effects on natural hormone production, it is essential to follow an appropriate post-cycle treatment (Post-Research Recovery Protocol) protocol.

Disclaimer

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