Buy RAD 140 for Sale (Testolone) – Product Information
RAD 140, also known as Testolone, is a non-steroidal selective androgen receptor modulator (SARM). Like other SARMs, it binds to specific androgen receptors and doesn’t cause the full spectrum of androgenic effects as similar substances like anabolic steroids, DHT, or testosterone replacement therapy.
Testolone hasn’t been around for long. This research compound was developed in 2010 as a potential treatment for osteoporosis. At the time of writing, it is being investigated as a research compound for its potential ability to enhance muscle hypertrophy and promote muscular gains.
Research has shown that the stability of RAD-140 is high in incubations with rats, monkeys, and human microsomes. The research compound has also demonstrated good bioavailability in rats and monkeys as well as excellent affinity for the androgen receptor in the skeletal tissue. [R]
Recent studies investigated the effects of RAD-140 on levator ani muscle weight and prostate weight in castrated rats, which are sensitive markers of anabolic-androgenic action in young nonhuman primates. The final results showed that RAD-140 stimulates the levator ani muscle.
|Molar Mass||393.83 g·mol−1|
Multiple animal studies have been conducted on RAD 140. This research compound has also undergone numerous clinical trials or human studies. In this section, we’re going to highlight what research has unearthed so far about this research compound.
However, it must be understood that the Food and Drug Administration (FDA) hasn’t approved RAD 140 for human use. This drug should be used for laboratory research use only and not for human consumption.
RAD-140 and Neuroprotection
In a study involving rats, scientists investigated the potential ability of RAD 140 to offer neuroprotection in cultured rat neurons and male rat brain. In cultured hippocampal neurons, RAD 140 was observed to be as effective as testosterone in reducing cell death induced by apoptotic insults.
In experiments with gonadectomized male rats, RAD 140 exhibited neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate, highlighting its preclinical efficiency in neuroprotective actions relevant to Alzheimer’s disease. [R]
RAD-140 and Muscle Mass
One study investigated the anabolic effects of RAD140 in young, male cynomolgus monkeys. Researchers examined gross body weight, which we know to be a sensitive marker of anabolic androgen action in young nonhuman primates.
While there was no consistent effect on absolute fat mass, the muscle mass showed a qualitative trend that increased with dose. It appeared that the majority of muscle mass increase was due to lean mass increase. This shows the immense promise of potential muscular gains brought on by RAD 140.
In short, research suggests that RAD 140 may increase lean muscle. If the RAD 140 dosage is too little however, these effects will be limited in test subjects.
RAD-140 and Breast Cancer
RAD 140 is currently under investigation as a potential treatment for breast cancer.
In a cell study, oral administration of RAD 140 inhibited the growth of AR/ER+ breast cancer via the androgen receptor-mediated suppression of the ESR1 gene, both as a single agent and in combination with palbociclib (prescription medicine for certain types of breast cancer). [R]
Androgen and estrogen-receptor-positive (AR/ER+) is a common form of breast cancer. It is sensitive to hormones, and therefore, medications that affect these receptors, such as SARMs like RAD 140, are being investigated for their cancer-fighting potential. [R]
How Does RAD 140 Work?
RAD 140 works by selectively targeting androgen receptors in the muscle and bone tissue, leading to an increase in lean muscle mass and decrease in body fat.
This distinguishes RAD, as well as other SARMs, from anabolic steroids, testosterone, and DHT which do not spare androgen receptors in the reproductive organs.
Is RAD-140 Legal?
RAD 140 is legal to buy and sell as a research compound.
However, since this drug is on the World Anti-Doping Agency’s (WADA’s) list, it cannot be used by athletes and professionals. It is also illegal for human consumption.
What Is The Half Life of RAD-140?
There are conflicting reports about the half-life of RAD 140. While some reports put the half-life at 16 hours, others state that the drug has a long half-life of up to 60 hours.
Does RAD-140 Cause Testosterone Suppression?
According to a study conducted in 2010, 28 days of dosing with RAD 140 suppressed testosterone levels by approximately 200 – 300 ng/dL, with similar suppression in all three groups, although testosterone levels were significantly different for only the 0.01mg/kg group (p < 0.05). [R]
Does RAD-140 Cause Acne?
There is no mention of RAD 140 causing acne in this drug’s various animal studies.
Is RAD-140 Orally Bioavailable?
In pre-clinical characterization, this research compound had good bioavailability in rats and monkeys. Further research is needed to verify its bioavailability in humans.
Where to Buy RAD-140 Online
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In order to be the best SARMs supplier, we provide reference materials with every product we sell. Each of our SARMS comes with an independent, third-party issued Certificate of Analysis for identification, purity, and concentration.
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RAD-140 has demonstrated anabolic activity on muscle in preclinical studies in rats and monkeys. In pre-clinical characterization, this research compound has demonstrated excellent affinity for the androgen receptor. RAD also had good bioavailability in rats and monkeys.