Description

Nephilim’D Transdermal (S-23 + YK-11 + LGD-4033 + 5a Hydroxy Laxogenin) – Product Information

Nephilim’D is a research compound that combines S-23, YK-11, LGD-4033, and 5a Hydroxy Laxogenin. This unique formulation aims to explore the potential synergistic effects of these compounds.

S-23 is a selective androgen receptor modulator (SARM) known for its potential to promote lean muscle mass and enhance strength. YK-11 is another SARM that may aid in muscle growth and recovery. LGD-4033, also a SARM, is recognized for its anabolic properties and potential benefits in muscle development. 5a Hydroxy Laxogenin is a compound believed to have muscle-building potential and aid in recovery.

By combining these compounds, Nephilim’D offers researchers an opportunity to study the combined impact on muscle development, strength gains, and overall body composition. However, it is essential to reiterate that this product is strictly intended for research purposes.

• Nephilim’D consists of S-23, YK-11, LGD-4033, and 5a Hydroxy Laxogenin.
• Nephilim’D Transdermal is offered as 10mg S23, 5mg YK-11, 10mg LGD 4033, and 7.5mg 5a-Hydroxy Laxogenin, totaling 32.5mg per ml for 60ml or 1950mg in total.

S-23

According to the available studies, S-23 induced infertility in all rats it was exposed to. These effects are dose-dependent and temporary, meaning the rats regained fertility following treatment. This shows the potential of S23 as an oral male contraceptive.

According to the research, S-23 subdues serum concentration of luteinizing hormone and follicle-stimulating hormone to produce biphasic effects on spermatogenesis. Additional research and clinical trials should be conducted to determine the efficacy and safety of S23 as an oral contraceptive.

The above-mentioned study produced other beneficial and desirable effects. For instance, researchers observed a stronger affinity to androgen receptors as compared to other popular compounds like Andarine. It also has an ideal anabolic-androgenic ratio allowing it to produce a good number of positive effects without any severe complications. One of those effects was increasing bone mineral density and lean muscle mass.

Therefore, while S-23 may potentially be effective as a male birth control pill, it can also be studied for other purposes, especially among patients with chronic conditions that lead to muscle wasting.

S-23
CAS Number	1010396-29-8
Molar Mass	416.76 g·mol−1
Chemical Formula	C18H13ClF4N2O3
IUPAC Name	(2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

YK-11

A recent study has shown that YK11, a selective androgen receptor myostatin inhibitor, accelerates the expression of Follistatin in mice. Follistatin is a myostatin and activin-binding protein naturally found in the human body and has been used as a treatment for several degenerative muscle diseases. When follistatin levels are raised, myostatin levels will be inhibited. Inhibition of myostatin results in increased muscle mass and improved strength.

This study revealed that mice with low levels of myostatin have twice the amount of muscle mass compared to mice with high levels of myostatin. This shows the massive potential to be researched in the strong anabolic effects of YK-11.

YK-11
CAS Number	1370003-76-1
Molar Mass	430.541 g·mol−1
Chemical Formula	C25H34O6
IUPAC Name	methyl (2E)-2-[(8R,9S,10R,13S,14S,17S)-2′-methoxy-2′,13-dimethyl-3-oxospiro[1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-17,5′-1,3-dioxolane]-4′-ylidene]acetate

LGD-4033

A recent study set out to investigate the safety, pharmacokinetics, and effects of LGD 4033 in healthy young men. It found LGD-4033 to be safe, possessing a favorable pharmacokinetic profile, and increasing lean body mass even during a short 21-day period. Longer randomized trials and research could potentially evaluate its efficacy in improving physical function and health outcomes in select populations.

LGD-4033
CAS Number	1165910-22-4
Molar Mass	338.253 g·mol−1
Chemical Formula	C14H12F6N2O
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

5a-Hydroxy Laxogenin

Known as 5 alpha hydroxy laxogenin or 5a hydroxy laxogenin, laxogenin is a compound derived from a plant and is best known as a member of the compound group collectively referred to as brassinosteroids. While its mechanism of effect has yet to be fully understood, given its status as a brassinosteroid, the prevailing conclusion from preliminary studies to date is the possible effect it can have on the increase of protein synthesis whilst reducing protein breakdown. Laxogenin is also posited to have the ability to enhance muscle growth and recovery by inhibiting the stress hormone cortisol.

5a-Hydroxy Laxogenin
CAS Number	56786-63-1
Molar Mass	446.6g.mol-1
Chemical Formula	C27H42O
IUPAC Name	(1S,2S,4S,5’R,6R,7S,8R,9S,12S,13R,16S,18R)-16,18-dihydroxy-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2′-oxane]-19-one

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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