S4 Andarine + Ligandrol (LGD-4033) Stack

Description

What is the S4 Andarine + LGD-4033 (Ligandrol) Stack?

Andarine (S4) and Ligandrol (LGD-4033) are classified as Selective Androgen Receptor Modulators (SARMs). SARMs are small-molecule drugs that selectively act as agonists or antagonists on the androgen receptor (AR) throughout the body [R]. Similar to androgens, SARMs enter the cell’s cytoplasm and selectively bind to the AR, forming a SARM-AR complex that modulates a transcriptional response [R]. The effects of SARM-AR complexes vary mainly because of the different cofactors recruited during the process, AR expression patterns, and tissue-specific regulatory environments [R]. Because AR is widely distributed throughout the body, SARMs can target different tissues, including promoting skeletal muscle growth, reducing prostate size, and inhibiting breast cancer growth, without significant systemic side effects, which makes them a very promising drug for research [R] [R].

Andarine and Ligandrol are frequently used in research to optimize their synergistic effects in the investigation of muscle growth, strength, and fat loss. This impact is extensively studied to improve performance and appearance.

Possible Combined Benefits of the S4 Andarine + Ligandrol Stack

1. Enhance Muscle Growth:
   • Andarine and Ligandrol may increase lean muscle mass by stimulating muscle hypertrophy.
2. Fat Loss:
   • Andarine is potentially known for its fat-burning properties, helping your research to potentially get a leaner physique while preserving muscle mass.
3. Improved Recovery:
   • Faster recovery times enable more frequent and intense trials, contributing to better overall performance and muscle growth.
4. Bone Health:
   • Both SARMs can potentially enhance bone density, reducing the risk of fractures and supporting overall skeletal health.

S4 Andarine

CAS	401900-40-1
Molar M	441.4 g/mol
Chemical Formula	C19H18F3N3O6
IUPAC Name	(2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Andarine, commonly known as S4 or GTX-007, is an arylpropionamide SARM with a half-life of 4 hours [R]. Andarine was developed and is still being investigated as a potential treatment for muscle wasting, osteoporosis, and benign prostatic hyperplasia (BPH) [R].

How does S4 Andarine work?

S4 mimics a well-known drug by attaching to androgen receptors, initiating protein anabolism in muscle and bone tissue, while producing fewer androgenic side-effects like virilization, voice deepening, aggression, male baldness, body hair growth, and negative effects on the prostate [R].

The main advantages of SARMs over traditional steroid therapies have demonstrated a higher tissue selectivity in muscle and bone, while steroid side effects linked to androgen tissues are significantly reduced [R]. AR activation by SARMs, which are not substrates for 5α-reductase and aromatase, excludes amplified androgenic and estrogenic functions in tissues like the prostate and seminal vesicles observed after administration of testosterone and other anabolic androgenic steroids. In vitro and in vivo studies reveal that Andarine has fewer side effects than anabolic-androgenic drugs due to its focus on 5α-reductase, which creates DHT in the prostate[R] [R].

S4 Andarine may help in:

• Anti-cancer therapy [R] [R] [R] [R]
• Bone strength and fat loss [R][R]
• Body mass recovery [R] [R] [R]

Safety and Side Effects

Andarine potential to boost lean muscle growth, increase strength, promote fat reduction, and support bone health makes it an interesting topic for research. While Andarine has a lower risk profile than other known anabolic drugs, it is vital to utilize it properly and conduct post-cycle treatment (PCT) to restore natural hormone levels in test subjects. Due to its nature, andarine may potentially be an endocrine disruptor.

What is Ligandrol?

CAS	1165910-22-4
Molar Mass	338.25 g/mol
Chemical Formula	C14H12F6N2O
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Ligandrol, also referred to as Ligandrol or VK5211, is a highly selective non-steroidal SARM with a reasonably high binding affinity that has been explored in many preclinical and clinical scenarios [R].

How it works

The highly selective binding of Ligandrol is due to its high affinity (Ki of ~ 1 nM) to androgen receptors. In animal models, LGD-4033 has demonstrated anabolic activity in the muscle, anti-resorptive and anabolic activity in bone, and a robust selectivity for muscle versus prostate [R].

Ligandrol may help in:

• Osteoporosis [R] [R] [R]
• Hip fracture recovery [R][R]
• Improving lean body mass, muscle strength, and sex hormones[R] [R] [R]
• Reducing prostate activity leads to its enlargement [R]
• Sarcopenia [R]

Safety and Side Effects

LGD-4033 was safe and well tolerated, as shown in the long-term investigation. Evidence of the compound’s androgenic action is seen in a rise in LBM and considerable suppression of testosterone, sex hormone-binding globulin, and HDL cholesterol levels [R][R]. However, as with all SARMs, the drug has not achieved FDA approval and only remains in phase II of clinical trials. Reports on off-target liver toxicity and cardiovascular effects caused by LGD-4033 are still under investigation [R].

Conclusion

The Andarine and Ligandrol (LGD-4033) Stack is a potent combination for research into considerable muscle development, strength enhancement, and fat reduction, with a relatively low-risk profile. The most often misused SARMs include ligandrol (LGD-4033), ostarine or enobosarm (S-22 or MK-2866), and andarine. As a result, correct dose, cycle management, and post-cycle treatment in a research context are critical for optimizing benefits while avoiding potential negative effects.

FAQ

Is S4 Andarine + Ligandrol Stack safe?

In addition to a lack of consistent evidence of direct benefits, the potential long-term effects of using S4 Andarine + Ligandrol Stack are also unknown. Purerawz sells S4 Andarine + Ligandrol Stack for research purposes only. The data presented rely solely on scientific studies that are for reference purposes only.

Where to Buy S4 Andarine + Ligandrol Stack Online?

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Disclaimer

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