Noopept – Product Information
Noopept is a synthetic nootropic research chemical. Clinical research has demonstrated that Noopept potentially reduces general irritability and anxiety, potentially reduces sleep disturbances, and potentially improves overall emotional stability in patients with mild cognitive disorders.
Additionally, human studies have shown that Noopept may have the potential ability to reduce the recovery time patients need after brain injuries. In preclinical or animal studies, the synthetic smart compound has been found to potentially expedite the brain’s speed of forming and retrieving memories.
Pure Rawz sells this compound for research purposes only.
|Molar Mass||318.373 g·mol−1|
|IUPAC Name||Ethyl 1-(phenylacetyl)-l-prolylglycinate.|
What is Noopept?
Noopept (N-phenylacetyl- l prolylglycine ethyl ester) is a synthetic nootropic that is similar to Piracetam in structure and function. However, despite being a synthetic analog of Piracetam, Noopept manifests itself at doses 1,000 times lower than those for Piracetam. [R][R]
Noopept was originally developed at the Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences, in 1996. The smart compound is clinically used in Russia to treat traumatic brain injury, cerebral vascular disease, and various cognitive disorders. [R]
Unlike most natural nootropics, Noopept doesn’t take too long to start working. Preclinical research has shown that its potential effects can be felt within minutes, rather than hours or days. Rodent studies have further demonstrated that the impact of Noopept can last for hours. [R]
How Does Noopept Work?
It has been established that it potentially produces these effects:
Potentially increases the expression of NGF and BDNF in the hippocampus
Nerve growth factor (NGF) is a protein that plays a vital role in the development and survival of nerve cells that transmit touch and pain sensations. Brain-derived neurotrophic factor (BDNF), also a protein, is critical for learning and long-term memory in the central nervous system. [R][R]
May enhance the neural response to acetylcholine
In an animal model of passive learning avoidance, Noopept increased the neuronal response to the micro-application of acetylcholine. Acetylcholine is a neurotransmitter that plays a vital role in learning, memory, attention, and autonomic body functions. [R][R]
May reduce the levels of inflammatory cytokines
In a rat model of acute exudative inflammation, the administration of Noopept (5 mg/kg) significantly reduced IL-6 levels in the animals’ blood serum. Aside from that, the synthetic nootropic reduced the levels of TNF-alpha (another inflammatory cytokine) by half. [R]
May repress the activity of stress-induced kinases
In a preclinical study, Noopept reduced the activity of various stress-induced kinases in the rat hippocampus. This is potentially significant because activation of stress-induced kinases leads to obesity and obesity-related disorders, such as liver cancer and heart failure. [R][R]
What follows is a summary of clinical, animal, and cell-based research on Noopept. The information given in this section is for educational purposes only and doesn’t constitute medical advice. Pure Rawz doesn’t sell this compound for human consumption.
A randomized comparative clinical trial of Noopept and Piracetam was performed in two groups of patients. All of the patients had mild cognitive disorders of vascular and traumatic origin. A total of 53 patients were enrolled and studied in the trial. [R]
Results from the study show that patients who received Noopept had potentially reduced irritability, weakness, and daytime drowsiness at the trial’s conclusion. They also experienced potential improvements in anxiety, depressed mood, and depth and duration of nocturnal sleep.
Additionally, an potential improvement was seen in the Noopept group’s ability to concentrate. They experienced possible enhancements in short-term memory (for ongoing events) and long-term memory (for the past). All these potential changes were evident from weeks 2-3 weeks of treatment.
A cellular model of Alzheimer’s disease (AD) was prepared to investigate the neuroprotective actions of Noopept. Results obtained from the study indicate that the nootropic could protect PC12 cells against the harmful actions of amyloid-beta, a peptide that contributes to the development of AD. [R]
Another study tested its neuroprotective activity in Down’s syndrome cortical neurons and normal cortical neurons treated with H2O2. Results show that Noopept potentially protected the cells from oxidative damage and apoptosis. Plus, its potential neuroprotective activity was higher than that of Piracetam. [R]
Yet another cell-based study showed Noopept may potentially decrease the activity of stress-induced kinases and increase the levels of the BDNF gene in the rat hippocampus. Both these effects shed further light on the potential neuroprotective effects of this synthetic nootropic. [R]
In a preclinical study involving diabetic rats, Noopept treatment reduced blood glucose levels. The synthetic nootropic also decreased HOMA-IR in the treated group. This indicates that Noopept might positively affect the treatment of pre-pubertal diabetes. [R]
Another preclinical study found that Noopept potentially attenuated diabetes-mediated neuropathic pain and oxidative hippocampal neurotoxicity. Neuropathic pain and oxidative hippocampal neurotoxicity are two major symptoms of diabetes mellitus, the most common form of diabetes. [R]
A mice study has established that single intravenous, single peroral, and prolonged peroral administration of Noopept inhibits inflammation in a dose-dependent manner. The most pronounced anti-inflammatory effect of Noopept was a significant reduction in chronic immune inflammation. [R]
A cell-based study compared the antioxidant efficiency of multiple antioxidants, including Noopept and Piracetam. Promising results from the study have made this dipeptide a potential clinical compound for treating disorders associated with endogenous antioxidant system deficiency. [R]
Data from comparative studies indicate that Noopept had the potential to significantly reduce the anxiety of patients with organic emotional liability and post-concussional (traumatic brain injury) syndrome. There was a potential huge decrease in anxiety on day 56 of Noopept treatment compared to baseline. [R]
Frequently Asked Questions
Does Noopept cause toxicity?
None of the studies consulted mention anything about Noopept toxicity.
What is the half-life of Noopept?
Noopept is reported to have a short half-life of 5-10 minutes.
What does Noopept do to the brain of subjects?
Noopept has been shown to potentially exert neuroprotective and nootropic actions in the brain of research subjects.
Where to Buy Noopept Online?
PureRawz is the best place to buy high-quality Noopept online.
In order to be the best supplier of research peptides, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. You can buy Noopept powder, Noopept capsules, and other lab-tested pure nootropics from Pure Rawz.
Various clinical and preclinical studies have shown that Noopept possesses potential nootropic, anxiolytic and neuroprotective properties. In addition, Noopept has also been shown to potentially improve cognitive function in patients with central nervous system disorders.
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