Orexin A

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Description

Orexin A – Product Information

  • Orexin A is offered in 5mg lyophilized powder.
  • In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

Orexin A is a naturally occurring neuropeptide sourced from the brain. Known for its role as a potential hypothalamic neuropeptide, Orexin A plays a crucial part in regulating various physiological functions, particularly the sleep-wake cycle. This neuropeptide’s influence on the amygdala potentially induces a state of wakefulness, making it a subject of interest in research related to circadian rhythms and sleep disorders. Its intricate potential involvement in the regulation of sleep patterns highlights its significance in the realm of neuroscience.

Disclaimer: This product information is intended for informational purposes only and is not intended to promote the purchase or use of any specific product. It is not a replacement for expert medical guidance, diagnosis, or treatment. Always ask your doctor or another skilled healthcare professional for advice if you have any concerns about a medical condition.

Orexin A  
CAS Number 205599-75-3
Molar Mass 3561.1 g/mol
Chemical Formula C152H243N47O44S4
IUPAC Name H-Pyr-Pro-Leu-Pro-Asp-Cys -Cys -Arg-Gln-Lys-Thr-Cys -Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2

 

What is Orexin A?

Orexin A (human, rat, mouse) is a substance that contains a specific quantity of the occurring naturally neuropeptide known as Orexin A. This hypothalamic neuropeptide-regulating compound plays a pivotal role in various physiological processes within the human body.

Type 1 narcolepsy, in which the participant has a momentary loss of muscle tone (“drop attacks” or cataplexy), is caused by a shortage of orexin in the brain due to the elimination of the cells that make it. Notably, it has a direct impact on feeding behavior, energy metabolism, and appetite regulation.

One of the prominent functions of Orexin A is its influence on the amygdala, a region of the brain associated with human emotions. This interaction not only corresponds to wakefulness induction but also has implications for regulating sleep-wake cycles. Additionally, Orexin A’s binding mechanism is of particular interest, especially in cases of orexin deficiency, such as in Narcolepsy, a neurological disorder affecting sleep patterns.

It’s worth noting that Orexin A is naturally found in both human and bovine systems, highlighting its cross-species relevance. This neuropeptide’s intricate involvement in energy homeostasis and its connection to various physiological and neurological functions make it a subject of ongoing scientific investigation. 

Possible Uses of Orexin A

Improved Wakefulness and Alertness

Orexin A’s interaction with the amygdala induces wakefulness, making it a potential aid in enhancing alertness and combating daytime sleepiness. Laboratory studies conducted on rodents have demonstrated Orexin A’s ability to promote wakefulness by activating brain regions responsible for maintaining alertness and vigilance. [R]

Regulation of Appetite and Feeding Behavior

Orexin A’s engagement in the regulation of feeding behavior and appetite underscores its potential significance in weight management and cultivating well-rounded eating habits. Research conducted on rats stimulated food consumption, further emphasizes its impact on hunger and satiety. Notably, the effect persisted for 4 hours, highlighting its ability to modulate eating patterns over time. [R]

Clinical investigations with test subjects have similarly suggested that Orexin A’s interaction with neural pathways tied to appetite can indeed exert an influence on dietary behaviors. [R]

Support for Energy Metabolism

Research suggests that Orexin A may impact energy metabolism, potentially contributing to metabolic regulation and energy expenditure. Laboratory investigations on animals have demonstrated how Orexin A administration can influence energy balance by affecting metabolic processes. [R]

Influence on Mood and Emotions

Orexin A’s connection to the amygdala and its potential impact on human emotions make it a subject of interest for potential mood regulation. Studies in rodents have shown that Orexin A can influence emotional responses and anxiety-like behaviors through its interactions with brain circuits involved in emotional processing. [R]

Potential Role in Sleep Disorder Management

In cases of orexin deficiency-related sleep disorders, such as Narcolepsy, Orexin A could hold promise in addressing disrupted sleep patterns. Clinical trials have explored the use of Orexin A analogs to restore normal sleep-wake cycles in test subjects with Narcolepsy, showing promising results in improving daytime wakefulness. [R]

It’s important to note that while laboratory research and clinical studies have provided insights into these potential benefits, individual responses can vary, and further research is needed to fully understand the effects of Orexin A 5mg. 

How Does Orexin A Work?

The mechanism of action of Orexin A revolves around its interaction with orexin receptors, a group of G protein-coupled receptors located within the brain. Orexin A, also known as hypocretin-1, is a neuropeptide that specifically binds to these orexin receptors, initiating a series of physiological responses.

Studies have shown that the binding of Orexin A to its receptors occurs in a dose-dependent manner, influencing various processes such as food consumption and eating behavior. 

Research involving porcine orexin (a related variant) and radiolabeled orexin has provided insights into the molecular interactions between the peptide and its receptors.

Key to Orexin A’s structural functionality is the disulfide bonds, particularly the lysine-threonine-cysteine-serine (Lys-Thr-Cys-Ser) sequence, which helps maintain its stability and high affinity for the receptors. This structural integrity is crucial for its efficacy as an active neuropeptide.

In vivo studies, often conducted on rodents like mice and rats, have suggested that the perifornical area of the hypothalamus is a critical site for Orexin A’s effects. When administered, Orexin A acts as an agonist, activating the orexin receptors and inducing various physiological responses. Its potency as a regulator of wakefulness, appetite, and other processes has drawn considerable interest.

Notably, research use of Orexin A has shown that its effects can persist over time, highlighting its potential as a therapeutic agent. Investigations involving injections of Orexin A have indicated its role in influencing neural pathways related to sleep-wake cycles, eating behavior, and other physiological functions.

Frequently Asked Questions

How is Orexin A produced in the body?

Orexin A is produced naturally in the body as a result of the processing of its precursor molecule, prepro-orexin. These neuropeptides are synthesized primarily in a specific region of the hypothalamus and play a vital role in modulating various neural circuits.

What is a protein-coupled receptor, and how do they relate to Orexin A?

Protein-coupled receptors are a class of cell membrane receptors that play a key role in transmitting signals from outside the cell to the inside. Orexin A interacts with these receptors, particularly orexin receptors, initiating a cascade of intracellular events that lead to various physiological responses.

Can Orexin A be used for diagnostic purposes?

While Orexin A itself is not commonly used for diagnostic purposes, the study of its levels and interactions in the body has been of interest in fields like sleep research and neurological disorders. Changes in Orexin A levels have been associated with conditions like Narcolepsy, providing insights into potential diagnostic applications.

Where Can You Buy Orexin A Online?

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Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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