Phenibut HCL – Product Information
Phenibut HCL is a synthetic neuropsychotropic drug. It was initially developed in Russia and is currently used there to treat anxiety, alcohol withdrawal, insomnia, tension, and stammering. In the US, the Food and Drug Administration (FDA) hasnât approved it for any clinical use.
Preclinical studies have reported that Phenibut HCL possesses anti-convulsant properties. The drug has also exhibited nootropic (cognition enhancing) and anxiolytic effects in various mice studies.
However, there have been reports of Phenibut causing toxicity and dependence.
PureRawz sells Phenibut HCL for laboratory research use only.
What is Phenibut HCL?
Phenibut HCL is a neuropsychotropic compound, which means it affects the userâs mental state. It was initially synthesized in the former Soviet Union in the 1960s. Phenibut HCL is an analog of gamma-aminobutyric acid (GABA), a brain chemical that helps you calm down. [R][R][R]
Phenibut is available as a prescription drug in Russia. It is used in the country to treat common sleep, anxiety, and speech disorders. Its anti-anxiety effects once helped Phenibut become a part of the Russian cosmonaut space kit to help astronauts stay calm under pressure. [R]
In various preclinical studies, Phenibut HCL has demonstrated promising effects. It has exhibited anti-convulsant, nootropic (cognition enhancing), and anxiolytic properties. Plus, in experimental models of fear, Phenibut facilitated miceâs escape from stressful situations. [R]
Notwithstanding its promising effects, Phenibut HCL has a poor safety profile. Multiple case studies associate its use with dependence and withdrawal symptoms. One case study reports a person who had to be hospitalized due to acute Phenibut intoxication. [R][R]
How Does Phenibut HCL Work?
Phenibut acts as a GABA-mimetic (it imitates the effects of GABA). It primarily activates the GABA (B) and, to some extent, GABA (A) receptors. This may explain Phenibut HCLâs potential anxiolytic effects, as GABA reduces the excitability of brain cells to help you calm down. [R][R]
Phenibut has also been shown to stimulate dopamine receptors and increase the concentration of dopamine at low doses. The tranquilizer and nootropic compound has also been found to antagonize beta-phenethylamine (PEA). PEA is a central nervous system stimulant. [R][R]
Pure Rawz doesnât sell Phenibut HCL for recreational purposes.
More than 300 studies about Phenibut have been published to date. However, the problem with these studies is that most are in Russian and were conducted inside Russia. More clinical studies on randomized populations are needed to examine Phenibut HCLâs safety and efficacy
Phenibut and Anxiety
In a 2-month, open-label trial conducted in Russia, Phenibut treatment (250 mg/day) significantly reduced anxiety and sleep disorders in children with tension-type headaches (TTH). There was also a significant decrease in the frequency, duration and intensity of TTH. [R]
Another study investigated the effects of Phenibut treatment on migraine patients. One group of patients received Metoprolol (beta-blocker) and the second group received Phenibut + Metoprolol. The final results showed that the second group had a greater reduction in anxiety levels. [R]
Two more studies reported that Phenibut treatment significantly reduced anxiety in patients with this mental health disorder. Furthermore, in both these studies, the patients administered this drug experienced a significant improvement in their sleep. [R][R]
Phenibut and ADHD
A 30-day open-label trial was carried out to investigate the effects of GABA-derivative Phenibut in ADHD patients. All the participants in the study had ages between 7 and 15. The final results show a significant improvement in attention and auditory verbal memory. [R]
In a 2018 study, Phenibut (500 mg/day for 45 days) caused significant improvement in ADHD symptoms in 63.3% of patients. However, while the above ADHD study reported no side effects, in this study 3 patients reported excessive daytime somnolence. [R]
Phenibut and Cognitive Enhancement
In a clinical trial of 62 people with anxiety-phobic disorders, Phenibut (1,000 mg/day) enhanced memory, attention, and emotional intelligence in 73% of the treated group. As for side effects, 3 patients reported excessive daytime somnolence (state of drowsiness). [R]
In two mice studies, Phenibut improved memory and helped rats learn more quicker. These effects were sustained and noticeable early on in the study. In a separate study, rabbits administered Phenibut experienced improved learning and reduced stress. [R][R][R]
Phenibut and Chronic Fatigue
According to a randomized placebo-controlled trial, Phenibut (500 mg/day for 8 weeks) decreased fatigue in patients with cerebrovascular disease. The reduction was experienced by Â¾ of all patients. Plus, the decrease was observed across all components of fatigue syndrome. [R]
In a small trial of 60 children with emotional fatigue (asthenia) and anxiety, Phenibut (500 mg/day) improved emotional symptoms in 2/3rd of the cases. Compared to a similar Russian drug, Phenibut was found to be more effective in children with residual asthenia. [R]
Phenibut and Insomnia
At least three clinical studies indicate that Phenibut benefits people with insomnia.
In one study, Phenibut administration took only 2 days to increase the duration of key sleep phases in alcoholics in early abstinence. It also reduced the duration of the drowsiness stage. However, it didnât affect the period the study participants took to fall asleep. [R]
Another study reported that people with anxiety had improved sleep quality after they were treated with phenibut HCL capsules. A third study found that the nootropic improved sleep in people with headaches. [R][R]
Phenibut and Heat Resistance
In a clinical trial involving volunteers working in a high-temperature environment, Phenibut (0.25 mg) increased heat resistance when given alongside another drug (Obsidan; 0.08 g), protecting the body from overheating. [R]
Another trial reported a single dose of Phenibut (250 mg) preventing overheating, improving oxygen supply, increasing tolerance to heat, and helping maintain high-working capacity. This trial was conducted on people performing intense physical exertion. [R]
Phenibut and Tension Headaches
Tension headaches refer to mild-to-moderate pain that feels like a tight band around the head.
According to a trial involving 30 children and adolescents, Phenibut treatment (5 â 20 mg/kg/day) for 2 months reduced the intensity, duration, and frequency of tension headaches. The participants also experienced improved productivity, sleep and anxiety. [R]
Phenibut and Tics & Stuttering
A clinical study investigated the effects of Phenibut on stuttering in children with tics.
One hundred and eight children with tics (ages 7 â 13) were enlisted for the study. Around 23.2% were found to be stuttering. Phenibut treatment decreased ticks in 80% of cases and stuttering in 66.7% of cases. [R]
Frequently Asked Questions
What is the half-life of Phenibut?
Phenibut (molecular weight 179.216 g/mol) has an elimination half-life of 5.3 hours. [R]
Where to Buy Phenibut HCL Online?
PureRawz is the best place to buy Phenibut online.
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Phenibut is an analog of the neurotransmitter GABA that has shown anxiolytic, anti-depressant, and cognitive-enhancing effects in clinical studies. Furthermore, in clinical trials, Phenibut nootropic has been shown to relieve tension headaches and insomnia.
The above information is for educational purposes only and doesnât constitute medical advice. Pure Rawz does not sell Phenibut as a dietary supplement and/or for human consumption. Our Phenibut product isnât intended to diagnose, treat, cure, or prevent any illness.