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S-23 – Product Information

According to the available studies, S-23 induced infertility in all rats it was exposed to. These effects are dose-dependent and temporary, meaning the rats regained fertility following treatment. This shows the potential of S-23 as an oral male contraceptive.

In the abovementioned study, S-23 produced other beneficial, desirable effects. For instance, researchers observed that S-23 displays a stronger affinity to androgen receptors as compared to other popular compounds like Andarine.

S-23 SARM also has an ideal anabolic-androgenic ratio, allowing it to produce a good number of positive effects without any severe complications. A couple of those effects were increased bone mineral density and lean muscle mass.

Therefore, while S-23 may be effective as a potential male birth control pill, it can also be used for other purposes, especially among patients with chronic conditions that lead to muscle wasting. PureRawz sells S-23 SARM for laboratory research use only.

CAS Number 1010396-29-8
Molar Mass 416.76 g/mol
Chemical Formula C18H13ClF4N2O3
IUPAC Name (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

What is The S-23 SARM?

S-23 is a selective androgen receptor modulator (SARM).

SARMs are compounds that selectively target androgen receptors (ARs) in certain tissues, but not in others. They have similar anabolic properties to anabolic steroids but with reduced androgenic (producing male characteristics) properties. [R]

In a rat study, S-23 has demonstrated potential use for hormonal male contraception. Either no sperm or very low sperm counts in the testis were successfully achieved in animals that received combination treatment. Plus, a 100% infertility rate was observed. [R]

S-23 also increased bone mineral density and lean mass but reduced fat mass in a dose-dependent manner. Its beneficial effects on muscle, and tissue selectivity, and favorable pharmacokinetic properties make S-23 a strong candidate for use in oral male contraception.

How Does The S-23 SARM Work?

Similar to other SARMs, S-23 selectively binds to androgen receptors in the muscles and bones, while only mildly affecting the prostate and other tissues. This was also evident in the abovementioned study, in which S-23 partially maintained prostate and seminal muscles.

Animal studies have shown that S-23 SARM has a half-life of 11.9 hours. It has also been found that S-23 reaches peak concentrations within 4 hours of administration. However, in the absence of clinical studies, its absorption in humans is unknown. [R]

S-23 SARM Research

No human studies on the use of S-23 have been published to date. As a result, we have to rely on animal and cell-based studies to explore the potential effects of this research chemical.

In the latter, S-23 produced lean muscle gains, increased sexual desire, and achieved a dose-dependent suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). PureRawz sells S-23 for research use only and not for human consumption.

S-23 and Male Contraception

A rat study was conducted to determine the effects of combined S-23 and estradiol benzoate (EB) treatment. It found that the combination treatment is an effective and reversible regimen for male hormonal contraception in rats.

Furthermore, the beneficial effects of S-23 on the muscle, tissue selectivity, and favorable pharmacokinetic properties make it a strong candidate for use in oral male contraception. [R]

S-23 and Muscle Growth

In the abovementioned study, S-23 also increased lean muscle mass in mouse models. [R]

In another study, the effect of S-23 and Testosterone on glucocorticoid-induced muscle atrophy was observed. Glucocorticoids are the most widely used anti-inflammatory drugs in the world. However, their prolonged use might lead to undesirable side effects, such as muscle wasting or muscle loss.

This study confirmed that the atrophic effects of glucocorticoids are mediated at least partially via the suppression of IGF-1 signaling. More importantly, it found that the suppression was partially or completely inhibited by TP and S-23. These results confirm the anabolic effects of S-23 on protein synthesis. [R]

S-23 and Bone Density

The pharmacologic effects of S-23 were characterized in male rats as an animal model of male hormonal contraception. S-23 showed high binding affinity and was identified as a full agonist in vitro. This potential male contraceptive also increased bone mineral density in research subjects. [R]

Bone mineral density (BMD) is a crucial indicator of your bone health. A low BMD means you have an increased risk of osteoporosis, fractures, and other bone-related diseases. Medical practitioners use the BMD test to identify your risk of osteoporosis. [R]

S-23 and Fat Loss

In the abovementioned animal study, animals treated with estradiol benzoate (EB) and S-23 were leaner than intact controls with lower average weight and significantly less percentage of fat mass. A high inverse correlation existed between the dose rate of S-23 and the percentage of fat mass in rats.

S-23 and Female Sexual Motivation

A rat study set out to investigate the effects of S-23 on the sexual motivation of ovariectomized female rats. All females that received S-23 demonstrated a significant increase in sexual motivation, with similar increases seen at doses ranging from 0.05 mg/day to 3 mg/kg/day. [R]

Where to Buy S-23 SARM Online

PureRawz is the best place to buy S-23 SARM online.

In order to be the best research chemicals supplier, we provide reference materials with every product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.


What is The Half-Life of S-23 SARM?

Animal studies have shown that S-23 SARM has a half-life of 11.9 hours.

What is The Molecular Formula of S-23 SARM?

S-23 has a molecular formula of C18H13CIF4N2O3. Its molecular weight is 416.76 g/mol


S-23 has demonstrated promise as a potential male hormonal contraceptive pill in animal studies. This SARM also increased muscle mass, decreased fat, and improved bone mineral density in animal studies. However, no clinical studies have been conducted on S-23 to date.

PureRawz sells S-23 for research and laboratory use only.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.


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6 reviews for S-23

  1. baley

    Greatest Product i have used highly recommend it !!!

  2. Dogity Gunter

    I did an intense leg session last week. But it felt like I wanted to do more. My energy an strength levels have improved quite a bit. I recommend this to those who want to get the best out of their fitness journey

  3. Terrance Page

    My energy and physical levels have significantly increased. This is something I encourage to those who want to get the most out of their fitness experience.

  4. Jason

    I’m so glad I found this, such a fantastic product!

  5. ogreens113

    Impressive quality!

  6. jonstark

    This offers a competitive edge in my fitness journey without harmful side effects.

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