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J147 – Product Information

  • J147 is offered as 500mg powder.
CAS Number 1146963-51-0
Molar Mass 350.33 g/mol
Chemical Formula C18H17F3N2O2
IUPAC Name N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide


What is J147?

J147 is an experimental compound derived from the polyphenol compound curcumin found in turmeric and ginger. It was first developed in 2011, but its molecular mechanism of action was only recently discovered. The compound is thought to act as a potent neuroprotective agent that may improve memory.

It also holds potential as a preventive treatment for neurodegenerative diseases, illnesses caused by the degeneration of neurons in the brain.

This neurotrophic compound could potentially aid patients with Alzheimer’s from a debilitating cognitive decline caused by the disease’s progression. The compound has also been discovered to slow the aging process and has memory-enhancing properties.

Although J147 seems to offer many benefits, all of these still require large-scale clinical studies.

Thus, this compound is not FDA-approved for human consumption. Purchase this chemical formulation for research purposes only.

Potential Benefits of J147

J147 powder was created in 2011 at the Salk Institute’s Cellular Neurobiology Laboratory. A number of studies confirmed its effect on Alzheimer’s disease and how it can slow the aging process before its inception.

J147 can improve cognition temporarily despite not inhibiting acetylcholine or phosphodiesterase enzymes like current AD treatments do.

J147 has alleged benefits affecting the brain cells. Some of these are memory enhancement, increased learning capacity, and neuro-rejuvenation.

J147 and Alzheimer’s disease

According to a laboratory-controlled study, J147 could potentially help Alzheimer’s patients by slowing the progression of the disease. Furthermore, J147 curcumin modulates neurotrophin signaling to ensure neuronal survival and, as a result, memory formation and cognition. [R]

Another study discovered that J147 Alzheimer’s compound increases both nerve growth factor and brain-derived neurotrophic factor. These neurotransmitters aid memory formation, learning, and cognitive functions. [R]

J147 is a Potential Nootropic

J147, as a promising nootropic, can reverse severe cognitive deficits in even the most elderly animal models. [R]

The research compound can also help with spatial memory and long-term potentiation. As a result, it could help improve memory and learning abilities. [R]

J147 May Improve Mitochondrial Function

J147 may increase ATP levels indirectly by improving mitochondrial function, a specific study suggests. J147 shows the potential to mitigate oxidative stress and improve mitochondrial function. For example, it demonstrated the capability to improve mitochondrial function by increasing ATP levels (inhibiting ATP synthase, specifically ATP5A). [R]

J147 May Help Patients with Diabetes

J147 has been shown in animal models to decrease blood glucose and HbA1c levels by increasing AMPK. [R]

Although not statistically significant, J147 may improve the function of residual beta cells in diabetes, as well. [R]

J147 and Diabetic Neuropathy

Diabetic peripheral neuropathy (DPN) is a condition in which nerve damage occurs as a result of chronically elevated blood glucose levels, as seen in poorly controlled diabetes. J147 may be useful in treating this complication.

J147 dosages were found to alleviate DPN in rats both in vivo and in vitro by negatively regulating AMPK on TRPA1. J147 has been proposed as a non-pharmaceutical alternative to the polypharmaceutical approaches required to treat the multiple pathogenic mechanisms that contribute to diabetic neuropathy. [R]

J147 May Treat Major Depressive Disorder

Major depressive disorder (MDD) is a severe mental disorder caused by a lack of monoamine neurotransmitters, specifically 5-HT (5-hydroxytryptamine, serotonin) and its receptors.

A previous study found that acute treatment with a novel curcumin derivative J147 had antidepressant-like effects in the hippocampus of mice by increasing brain-derived neurotrophic factor (BDNF) levels. [R] [R]

J147 and Anti Aging

According to certain researchers, the J147 anti-aging compound potentially rejuvenates aging cells.

Mitochondrial dysfunction hastens the aging process. Cellular homeostasis will deteriorate, resulting in a decrease in physiological activity. Furthermore, the production of ROS will result in cell damage and mitochondrial deterioration (reactive oxygen species). Taking J 147 powder will counteract this effect, slowing reduce aging. [R]

Memory deficits and neurodegenerative disorders are also linked to aging. On the other hand, several J147 case studies support the drug’s efficacy in reversing memory loss, improving cognitive abilities, and treating dementia, Alzheimer’s, and other age-related diseases.

All of the purported health benefits of J147 mentioned above are still in need of in-depth studies. J147 cannot be considered a safe form of cure or treatment because it is still a research chemical.

Purchase this compound for the purposes of studying its potential applications.

How Does J147 Work?

The experimental compound works by potentially influencing the body’s natural energy and focus requirements by binding to the ATP synthase enzyme. This mitochondrial protein regulates the aging process by moderating the production of cellular energy.

The presence of J147 in the human system prevents age-related toxicities caused by dysfunctional mitochondria and ATP overproduction.

The mechanism of action of J147 will also increase the levels of various neurotransmitters such as NGF and BDNF. Moreover, it lessens beta-amyloid levels, which are always elevated in Alzheimer’s and dementia patients.

J147 effects include slowing the progression of Alzheimer’s disease, preventing memory loss, and increasing neuronal cell production.

Frequently Asked Questions

Is J147 Safe?

J147 is still a research compound, meaning using it as a form of food supplement or treatment is extremely inadvisable. Several studies are needed before this experimental chemical may be declared safe for human consumption.

Why is J147 gluten-free?

Because J147 does not contain gluten, it can be used to study celiac disease or other dietary restrictions. For instance, if an animal laboratory subject cannot consume dairy products, they should take J147, which is lactose and casein free.

Is J147 a Potential Treatment for Alzheimer’s Disease?

J147 is an experimental compound that has been shown in animal studies that appears to be extremely potent, safe, and orally active. J147 is a potential Alzheimer’s disease treatment because of its ability to provide immediate cognitive benefits, as well as the potential to halt and reverse cognitive impairment in symptomatic animals.

What is the source of J147?

Curcumin is a polyphenol and the active component of turmeric and ginger. Curcumin has many proven benefits in the treatment of numerous diseases, but there are clear limitations due to its poor ability to cross the Blood-Brain Barrier (BB).

J147 (CAS:1146963-51-0) is a Curcumin and Cyclohexyl-Bisphenol A (CBA) derivative that is both neurogenic and neuroprotective. It was created to treat neurodegenerative conditions associated with aging.

Where can you buy J147?

PureRawz is the best online store to buy J147.

We provide reference materials with every product we sell to be the best supplier of research chemicals. Our products are all accompanied by an independent, third-party Certificate of Analysis for identification, purity, and concentration.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.
All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at [email protected]
ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

10 reviews for J147

  1. nathan

    Very happy with the results for this, it is truly a joy to use!

  2. Mark Anderson


  3. Anton

    Very happy with the results as a first time buyer. I am really impressed with your product.

  4. Brian Stags

    Delivery time was not too good. But your customer team helped me get my order out. Thanks you for all the help

  5. Philip Rogers

    Like everything about this product! When I think about how much faster my mind has been remembering stuff, I’m amazed! Where did I leave the keys? Right away I remember!

  6. Matt R

    I really like how they work. I feel more focused, and I actually remember everything.

  7. Dean Almas

    Thank you for the speedy delivery this time.

  8. Jarvis

    I have been very happy with the results I’ve seen from using J147. Highly recommended!

  9. Russell Richardson

    I highly recommend this if you find yourself having any memory or mind issues.

  10. abegailhebie

    I’m amazed by its cognitive enhancing effects.

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