Gonadorelin

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Description

Gonadorelin – Product Information

Gonadorelin is a gonadotropin-releasing hormone (GnRH) agonist. GnRH causes the pituitary gland to potentially increase the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In men, LH and FSH increase testosterone production. In women, they boost estrogen production. [R]

Research has shown that gonadorelin treatment may have the potential to have a positive effect on bone mineral density (BMD) and metabolic parameters of patients with a specific disease. Aside from that, in women undergoing chemotherapy, GnRH agonists protect the function of the ovaries. [R][R]

In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

PureRawz sells Gonadorelin for research purposes only.

Gonadorelin
CAS Number 9034-40-6
Molar Mass 1182.311 g/mol
Chemical Formula C55H75N17O13
IUPAC Name (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide

What is Gonadorelin?

Gonadorelin is a synthetic peptide composed of ten amino acids. It has a molecular weight of 1182.3 g/mol. Gonadorelin is structurally similar to the gonadotropin-releasing hormone (GnRH). GnRH is responsible for stimulating the release of LSH and FSH from the anterior pituitary. [R]

In medicine, gonadorelin is used to test how well the pituitary glands and hypothalamus are working. It is also used as part of female infertility treatment. That is because gonadorelin stimulates the release of GnRH to help produce mature eggs from ovaries. [R]

How does Gonadorelin Work?

Gonadorelin works by stimulating the pituitary gland to increase the production of LSH and FSH. Both these hormones then travel to the testes or the ovaries, where they stimulate the release of testosterone or estrogen and progesterone. All three are sex hormones. [R][R]

Gonadorelin comes to the pituitary in pulses. The speed of the pulses indicates to the pituitary which hormone to produce. When Gonadorelin pulses are slow, the pituitary produces more FSH than LH. When gonadotropin pulses are fast, the pituitary gland produces more LH than FSH. [R]

Gonadorelin Research

Multiple clinical trials have been conducted on gonadorelin. This synthetic peptide has also attracted various animal and cell-based studies. These trials and studies have shed light on the various potential beneficial effects of this research chemical.

Pure Rawz sells Gonadorelin for research purposes and not for human consumption.

Gonadorelin and Breast Cancer

Based on data suggesting that GnRH analogs can be used with fewer side effects for breast cancer prevention in postmenopausal women, researchers have proposed that gonadorelin be used for breast cancer prevention in the specific target group. [R]

A separate study showed how the administration of GnRH analogs reduced circulating concentrations of estrogen in postmenopausal women by blocking estrogen receptors. This target group (postmenopausal women) is at the highest risk of developing breast cancer. [R]

Multiple studies have associated the anti-tumoral functions of gonadorelin with the reduction in proliferation, invasion, and migration of breast cancer cells. Aside from that, this GnRH has been shown to increase apoptosis and inhibit the metastasis of BC cells. [R] [R] [R]

Gonadorelin and Male Infertility

A 2016 study presented a male subject with hypogonadotropic hypogonadism (HH), azoospermia (no sperm to ejaculate), and a history of previous anabolic steroid use. The subject underwent gonadotrophin therapy and was subsequently able to achieve conception. [R]

Furthermore, GnRH may be potentially very effective in inducing spermatogenesis, inducing the production of mature sperms in about 85% of patients. On average, about 60% of couples achieve pregnancy after only nine months of treatment. [R] [R]

Finally, some men who receive GnRH treatment could potentially see improvement in their sexual characteristics, such as an increase in testicular volume and other features like public hair growth. These changes are positive pre-indicators of treatment success. [R]

Gonadorelin and Prostate Cancer

A study indicates that a treatment known as combined androgen blockade (CAB) makes it possible to cure at least 90% of all localized prostate cancer cases. CAB treatment combines gonadorelin with newer, localized compounds already used for treating prostate cancer. [R]

Treatment using the CAB treatment can make death from prostate cancer an exception, provided the disease is diagnosed at an early stage. This isn’t difficult given that the presently available techniques can diagnose prostate cancer early in 99% of cases.

Gonadorelin and Bone Mineral Density

A clinical trial was conducted to determine the impact of gonadorelin treatment on the bone mineral density of young men with hypogonadotropic hypogonadism (HH). A total of 22 young male patients with HH and 20 healthy controls were enrolled in the study.

After six months of pulsatile gonadorelin treatment, bone mineral density in the lumbar spine 2-4, femoral neck, and total hip increased dramatically. The increase in bone mineral density in all these areas was statistically significant (P < 0.01, for all). [R]

Gonadorelin and Dementia

A 2005 study discovered that LH and GnRH possess neuronal receptors. LH is known to cross the blood-brain barrier, and the receptors for LH are most concentrated in the hippocampus, the brain region most vulnerable to Alzheimer’s disease (AD). [R]

Another study established that GnRH agonists may be therapeutic for AD. As part of the study, the rate of development of select diagnoses of dementia, including AD, was studied for a twelve-year follow-up period after surgery. Two groups of patients took part in the study.

When compared to control patients, subjects hospitalized with prostate cancer and administered GnRH therapy had shown potential protection against dementia. [R]

Gonadorelin and Ovarian Cancer

In a systematic review, researchers shed light on the role of GnRH in ovarian cancer development, progression, and therapy. It was found that GnRH agonists may potentially have a time- and dose-dependent anti-proliferative action in many cell lines from different cancer entities.

Furthermore, it was shown that GnRH agonists might potentially have anti-tumor effects in ovarian cancers. In addition, it was noted that the specific expression of GnRH receptors could be used diagnostically to treat metastases of ovarian cancers. [R]

Frequently Asked Questions

Is Gonadorelin a Growth Hormone Releasing Factor?

Gonadorelin is a synthetic analog of the gonadotropin-releasing hormone (GnRH). It stimulates the pituitary gland to increase the secretion of luteinizing hormone and follicle-stimulating hormone.

Where to Buy Gonadorelin Online?

PureRawz is the best place to buy Gonadorelin for sale.

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Disclaimer
This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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10 reviews for Gonadorelin

  1. Chris

    I would highly recommend this product !

  2. Markus Swannepoel

    I have been using this now for almost a month and I have to say it is excellent .

  3. Gino Anders

    I’m extremely satisfied with this product, it is helping me a lot.

  4. Jack Owens

    Fast delivery! I am a happy customer

  5. Savas S

    This is a great deal.

  6. Warren Sherry

    Your customer service made my day!

  7. Earl R

    As expected, the product performs admirably. I will update my review next week.

  8. Kurt

    My wife and I benefited greatly from this.

  9. Talon Waters

    The best Gonadorelin so far based on my experienced. 🙂

  10. davidjoseph.deasy

    Looks interesting

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