Vitamin B12 – Cyanocobalamin (Injectable)- Product Information
What is Vitamin B12 – Cyanocobalamin?
Vitamin B12, also known as cyanocobalamin, is a water-soluble vitamin that is very important for nerve growth and metabolism. One of the most important organic compounds that the body needs is vitamin B12. It belongs to the group of compounds called cobalamins. This vitamin is mostly found in foods that come from animals, such as milk, meat, and eggs.
Along with Vitamin B6 and Vitamin C, Vitamin B12 is known for its unique ability to be stored in large amounts. This vitamin is very important for energy metabolism and DNA synthesis because it acts as a catalyst for several important enzymes. But a lack of Vitamin B12 can suffer severe cases, with the red blood cells, the heart, and the nervous system. One of the biggest worries is how it affects homocysteine (Hcy) metabolism and the body’s methylation reactions. [R]
In certain research conditions where high-dose B12 therapy is needed, injectable B12 is a preferred choice. Although several studies also tried oral B12 use in research, in such cases, oral B12 may not be adequately absorbed, leading to B12 deficiency. Injectable B12 bypasses the digestive system, ensuring direct absorption into the bloodstream, making it a more reliable option for research. In this article, we’ll learn about the possible benefits and effects of Vitamin B12 (Cyanocobalamin) (Injectable).
|Vitamin B12 Cyanocobalamin|
|Molar Mass||1 355,38 g/mol|
|IUPAC Name||cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2R)-1-[3-[(1R,2R,3R,4Z,7S,9Z,12S,13S,14Z,17S,18S,19R)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-21-id-3-yl]propanoylamino]propan-2-yl] phosphate;cyanide|
How Does Vitamin B12 – Cyanocobalamin (Injectable) Work?
Vitamin B12’s potential pain-relieving effects happen through a number of different pathways. These pathways involve neural tissue and interactions with prostaglandin synthesis, including cyclooxygenase (COX) enzymes. [R]
Neural Tissue Regeneration: Vitamin B12 likes nerve cells a lot. Studies on animals suggest that B12 helps nerves grow back by making axons grow and Schwann cells change. This process helps with difficult nerve crush injuries and get back to work faster. Brain-derived neurotrophic factor (BDNF), which is important for nerve growth and repair, is also turned up by B12. Also, B12 speeds up the speed at which nerve impulses travel, which may be a sign of the regeneration process.
Interaction with COX Enzymes: COX enzymes help make prostaglandins, which are important for pain and inflammation. The direct effects of B12 on COX enzymes haven’t been studied much in animals, but research on rats with methyl-deficient diets (lack of B12) showed that inflammatory challenges caused COX2 levels to go up in the intestines. This shows that B12 may help keep COX2 levels in check when there is inflammation.
COX Inhibition and Pain Reduction: in laboratory tests patients B12 seems to interact with COX enzyme systems in the same way as nonsteroidal anti-inflammatory drugs (NSAIDs), which are known to reduce pain by blocking COX enzymes.
Vitamin B12 – Cyanocobalamin Research
Numerous studies have been conducted on the potential application of Vitamin B12 – Cyanocobalamin. Below are some of the relevant findings on mushroom products:
Vitamin B12 – Cyanocobalamin on Cobalamin Deficiency in Sheep
Cobalamin deficiency, which is also called Vitamin B12 deficiency, can cause sheep to have a lot of health problems and make them less productive. In this study, 10 lambs with this deficiency were chosen, and microencapsulated Vitamin B12 formulations in lactide-glycolide polymers were injected either intramuscularly or subcutaneously into the front of their necks. The results of the study show that microencapsulated Vitamin B12 in lactide-glycolide copolymers can be injected into sheep to increase and keep Vitamin B12 levels at a healthy level for at least 210 days. This new method is another way to prevent cobalamin deficiency in sheep. This will help the sheep population be healthier and more productive.[R] Further research is needed to understand how Vitamin B12 helps the deficiency in sheep so appropriate tests are still needed.
Vitamin B12 – Cyanocobalamin on Prenatal Depression Management
A study conducted using data from the 2005-2006 Survey found a high prevalence of both Vitamin B12 insufficiency and depressive symptoms in pregnant test subjects. While the connection between depressive symptoms and nutrient deficiencies like iron and folate has been established, the specific link between low-normal serum Vitamin B12 levels and depressive symptoms in pregnant test subjects had not been closely studied. The analysis revealed that pregnant test subjects with low-normal serum Vitamin B12 levels were 3.82 times more likely to experience depression, even after controlling for other factors like sociodemographic characteristics, pre-pregnancy BMI, hemoglobin, and folate levels. The study emphasized the importance of identifying and possibly treating pregnant test subjects with low-normal Vitamin B12 levels to enhance prenatal depression management. [R]
Vitamin B12 – Cyanocobalamin on Lower Back Pain
Low back pain is a common problem, especially in Westernized countries. Recent studies have looked at the possible link between vitamin B12 injections and a reduction in chronic low back pain. The study figured out how well intramuscular vitamin B12 injections work for possibly treating chronic low back pain. A thorough search of the literature turned up two double-blind, randomized, placebo-controlled trials, each with 60 participants. The results showed that vitamin B12 injections into the muscle led to possible improvements in low back pain and disability related to it, compared to the placebo groups. But more research is needed to look at the possible long-term side effects of these injections. [R]
Cyanocobalamin on Vegetarians
Vitamin B-12 deficiency can be categorized into four stages. In Stages I and II, there is insufficient holotranscobalamin II in the blood, leading to the depletion of vitamin B-12 stores in both plasma and cells. This early phase may not present obvious clinical signs. In Stage III, the levels of homocysteine (HCY) and methylmalonic acid (MMA) rise, indicating a functional deficiency of vitamin B-12. At the same time, the levels of holotranscobalamin II decrease, affecting the body’s ability to utilize vitamin B-12 effectively. In Stage IV, which is an advanced stage, clinical symptoms become apparent. These may include macroovalocytosis (abnormally large red blood cells), increased erythrocyte potassium requirements, and a drop in hemoglobin levels. The presence of these signs highlights a severe deficiency and potential complications. Research has demonstrated that more than 60% of vegetarians exhibit stage III vitamin B-12 deficiency, emphasizing the importance of regular monitoring of cobalamin levels in this dietary group. Detecting and addressing vitamin B-12 deficiency early is crucial in preventing further health complications for vegetarians. [R]
Vitamin B12 – Cyanocobalamin on Recurrent Aphthous Stomatitis (RAS)
Vitamin B12 is important for making blood stem cells and has been linked to oral mucosal diseases like recurrent aphthous stomatitis (RAS). RAS is a bothersome condition, and B12 has been thought of as a possible treatment because it can help grow new tissue in the mouth. But there are different pieces of evidence about whether or not a lack of B12 causes RAS. Several studies looked at how different kinds of B12 might act as treatments. The pain got a lot better when active B12 (methylcobalamin) was given through buccal discs and submucosal injections. When B12 was taken by mouth in higher doses (1000 g), it cut the number and length of RAS attacks. Compared to taking B12 by mouth, getting it through an injection worked in about half of the cases. A pain reliever in the form of an ointment also worked well. Based on what we know now, taking 1000 g of B12 sublingually every day for six months may help treat RAS, but we need to do more research to be sure. [R]
Vitamin B12 – Cyanocobalamin on Physical Performance
A study looked at how vitamin B12 and folic acid supplements for 2 years affected physical performance, handgrip strength, and the risk of falling in aged test subjects with high levels of homocysteine in their blood. The people who took part in the study and were at least 65 years old were given either 500 g of vitamin B12, 400 g of folic acid, and 600 IU of vitamin D3 every day or a placebo with 600 IU of vitamin D3. At the start and after 2 years, physical performance and handgrip strength were measured. Falls were recorded as they happened. During the follow-up period, both physical performance and handgrip strength went down, but there were no major differences between the groups. There were also no big differences in how long it took for the first fall to happen between the groups. But secondary analyses showed that age and physical performance interact, and the treatment was linked to better scores on the walking test at follow-up. Even though the overall results didn’t show a significant effect on physical decline and preventing falls, there were signs that it helped aged test subjects over 80 with their walking and physical performance. Also, it’s important to note that while this study looked at the effects of taking vitamin B12 and folic acid greater together, more research needs to be done to look at the effects of vitamin B12 alone on physical performance, handgrip strength, and the risk of falling in aged test subjects with high homocysteine levels.[R]
Vitamin B12 – Cyanocobalamin on Brain Function
A study examined the effects of vitamin B12 deficiency in infant test subjects from developing countries where mother test subjects lack enough animal protein in their diets. The researchers looked at records of 27 infant test subjects diagnosed with vitamin B12 deficiency. The infant test subjects had various symptoms like weakness, slow growth, vomiting, and developmental delays, along with a specific type of anemia. The diagnosis was confirmed through blood tests, and their vitamin B12 and folic acid levels were checked. All the infants improved with vitamin B12 treatment, and those with severe anemia got blood transfusions. The study highlights the importance of considering vitamin B12 deficiency in infant test subjects from poor backgrounds, as delayed diagnosis may lead to permanent nerve damage.[R] Further research is needed to understand the effects of vitamin B12 deficiency and folate deficiency in pediatric patients.
Vitamin B12 – Cyanocobalamin on Brain Function
Vitamin B12 plays a crucial role in brain function. The study provides an overview of the clinical presentation of the disease, which, if left untreated, may produce permanent degenerative lesions to the central nervous system (CNS). It is involved in maintaining two essential functions: nucleic acid synthesis and methylation reactions. Methylation reactions, particularly vital for the brain, rely on maintaining adequate levels of S-adenosylmethionine (SAM). Cobalamin deficiency can inhibit methionine synthase, leading to increased levels of homocysteine and S-adenosylhomocysteine (SAH), which can negatively impact brain health. SAM-mediated methylation reactions are vital for various processes in the brain, including neurotransmitter synthesis and gene regulation. Proper B12 levels are necessary to support brain function and prevent neurological conditions associated with deficiency, such as cognitive impairment and neuropathy. [R]
Frequently Asked Questions
How does excessive alcohol intake affect vitamin B12 levels in test subjects?
Excessive alcohol intake longer than two weeks may cause malabsorption of vitamin B12. can lead to vitamin B12 deficiency due to several factors. Alcohol can damage the stomach lining, reducing the absorption of vitamin B12.[R] It may also impair liver function, hindering the liver’s ability to store and release vitamin B12. Additionally, poor dietary choices and increased excretion of B12 through urine contribute to the deficiency.
How does Vitamin B12 interact with Neomycin and Pyrimethamine?
Drug interactions Neomycin and Pyrimethamine can interfere with the absorption and utilization of Vitamin B12 in the body. Furthermore, pyrimethamine invalidates folic acid as well. These drugs can disrupt the proper functioning of the gastrointestinal tract, leading to decreased absorption of Vitamin B12 in diagnostic microbiological blood assays.
Where to Buy Vitamin B12 – Cyanocobalamin (Injectable) Online
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Vitamin B12, also known as cyanocobalamin, is an important water-soluble vitamin essential for nerve growth and metabolism. It is mainly found in animal-derived foods like meat, milk, and eggs. Along with Vitamin B6 and Vitamin C, B12 can be stored in the body in large amounts and plays a crucial role in energy metabolism and DNA synthesis. Lack of B12 can lead to severe conditions affecting the red blood cells, heart, and nervous system. In research, injectable B12 is preferred in certain situations where high-dose therapy is needed, as oral supplements may not be adequately absorbed, leading to deficiency. Injectable B12 is more reliable for direct absorption into the bloodstream. Various studies have explored the potential benefits of Vitamin B12, such as its impact on nerve regeneration, pain relief, prevention of cobalamin deficiency in sheep, management of prenatal depression, lower back pain, recurrent aphthous stomatitis (RAS), and physical performance in the elderly. Additionally, B12 is crucial for brain function and preventing neurological conditions associated with deficiency. Proper monitoring and treatment of B12 deficiency are vital, especially for pregnant women and infants, to prevent irreversible nerve damage and health complications. Other studies are also examining the potential effects of Vitamin B12 – Cyanocobalamin on bone marrow suppressant properties, hereditary optic nerve atrophy, and severe megaloblastic anemia.
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