Epithalon

Description

Overview of Epithalon

Epithalon (also referenced as Epitalon or Epithalone) is a synthetic tetrapeptide with the amino acid sequence Ala-Glu-Asp-Gly (AEDG). 

It was synthesized as a defined analog of Epithalamin, a polypeptide extract from the bovine pineal gland. The compound allows for controlled investigation of peptide-based regulatory mechanisms under strict laboratory conditions.

Epithalon has been investigated in published cellular, animal, and limited clinical research examining telomere-associated pathways. 

Possible Research Applications of Epithalon

• Telomere Biology & Cellular Senescence Research

Telomere-related molecular pathway research , particularly in studies exploring telomerase-related pathways, chromosomal maintenance, and mechanisms associated with cellular signaling and molecular research. 

• Neuroendocrine & Pineal Signaling Research

Epithalon is frequently referenced in neuroendocrine research involving pineal signaling, circadian-related signaling pathways under research conditions. , and biomarker pathways.

• Oxidative Stress & Antioxidant Pathway Studies

Epithalon continues to be examined in oxidative stress-associated molecular pathways studied in vitro. This includes investigations involving redox balance, antioxidant-related signaling pathways, and mitochondrial function.

• Genomic and Chromatin-related Signaling Pathways

Epithalon and related peptides remain subjects of interest in genomic research focused on chromatin interactions, gene expression patterns, and pathways associated with pathways relevant to molecular and cellular research 

Chemical Properties of Epithalon

Pubchem CID	219042
Molecular Weight	390.35 g/mol
Synonyms	Epitalon 307297-39-8 Epithalon Epithalone Ala-Glu-Asp-Gly
Molecular Formula	C14H22N4O9
Storage	-20°C
2D structure
3D structure
CAS Number	307297-39-8
Purity	≥95%
Solubility	DMF: 1 mg/ml DMSO: 3 mg/ml PBS (pH 7.2): 5 mg/ml
Shipping	Room temperature in continental US; may vary elsewhere

Risk and Handling of Epithalon in Laboratory Settings

Epithalon is supplied as a lyophilized powder for research use only. It should be handled exclusively by qualified researchers in a controlled laboratory environment following established safety protocols.

Storage: Store lyophilized peptide at −20°C, protected from moisture and light. Once reconstituted, store at 4°C and follow the manufacturer's handling recommendations or your laboratory's validated procedures after reconstitution.

Handling precautions:

Wear appropriate PPE: nitrile gloves, safety glasses, and a lab coat when handling.

Reconstitute using an appropriate laboratory-grade solvent suitable for the intended research protocol.

Avoid repeated freeze-thaw cycles to maintain compound integrity. Dispose of unused material in compliance with applicable laboratory waste regulations.

Researchers are advised to consult the Safety Data Sheet (SDS) prior to handling. This compound is for research use only.

Why Choose Purerawz to Buy Epithalon?

Each batch of Epithalon from Purerawz undergoes rigorous first- and third-party testing, with a Certificate of Analysis (COA) available for verification prior to use.

Batch-specific purity testing is performed using analytical methods such as HPLC and mass spectrometry, with documentation available where applicable. 

Researchers can access batch-specific COA documentation to validate compound identity, molecular mass, and purity before initiating any experimental protocol.

FAQs

What is Epithalon made of?

Epithalon is a synthetic tetrapeptide composed of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. This precise sequence makes Epithalon recognizable within peptide research and analytical studies.

In what form is Epithalon typically supplied?

Epithalon is commonly supplied as a lyophilized (freeze-dried) powder, a format chosen to help maintain stability during storage and transportation prior to laboratory preparation.

How is Epithalon purity verified?

Epithalon quality is typically assessed through analytical testing methods such as HPLC and mass spectrometry, helping confirm identity, purity, and batch consistency.

Why is batch consistency important for Epithalon?

Consistent batches help ensure that each vial of Epithalon meets the same manufacturing and quality standards, supporting reliable handling and reproducible research conditions.

What should be evaluated before purchasing Epithalon?

Before selecting Epithalon, many buyers review factors such as certificate of analysis availability, testing transparency, manufacturing standards, and storage recommendations.

Disclaimer:

The products sold by Purerawz are intended solely for laboratory and research purposes. They are not FDA-approved for human or animal consumption, and Purerawz does not sell these compounds for use in humans or animals. All compounds are strictly for use by qualified researchers in controlled, non-clinical laboratory environments in compliance with applicable regulations.

References

1. Al-dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025. DOI: 10.1007/s10522-025-10315-x
2. Khavinson VKh, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590–592. PMID: 12937682. DOI: 10.1023/A:1025493705728
3. Korkushko OV, Khavinson VKh, Shatilo VB, Antonyk-Sheglova IA. Peptide geroprotector from the pineal gland of animals normalizes the daily melatonin rhythm in elderly people: results from 12 years of follow-up. Bull Exp Biol Med. 2007;144(6):745–748. PMID: 18856181. DOI: 10.1007/s10517-007-0381-3
4. Araj W, Łos-Rycharska E, Malinowski J, Chrobak E, Ciebiada M. Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. PMID: 40141334. DOI: 10.3390/ijms26062691
5. Avolio E, Martinotti S, Khavinson VK, et al. Peptides Regulating Proliferation and Survival of Basal Forebrain Cholinergic Neurons as Potential Therapeutic Lead Molecules in Alzheimer's Disease. Int J Mol Sci. 2022;23(9):5035. PMID: 35563425. DOI: 10.3390/ijms23095035