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Epithalon – Product Information

Epithalon, sometimes spelled Epitalon, is a synthetic version of the polypeptide Epithalamin. Studies have shown that Epithalon may possess the potential to increase the production of telomerase, an enzyme in the cells that plays a central role in cell fate and aging.

A study in mice suggests that premature aging can be reversed by reactivating telomerase. Mice that were engineered to lack the enzyme had become prematurely decrepit.

However, when telomerase was replaced, it bounced back to health. [R]

In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

PureRawz sells Epithalon for laboratory research use only.

Epithalon (Epitalon) Peptide
CAS Number 307297-39-8
Molar Mass 90.349 g/mol
Chemical Formula C14H22N4O9
IUPAC Name (4S)-4-[[(2S)-2-aminopropanoyl]amino]-5-[[(2S)-3-carboxy-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

Epithalon Structure

Epithalon contains four amino acids in the sequence Alanine-Glutamate-Asparagine-Glycine. It belongs to a class of peptides known as cell-penetrating peptides. CPPs have fewer than 30 amino acids in their chain and can transport molecules they are linked with across cellular membranes.

What is Epithalon?

Epithalon is a synthetic version of the polypeptide Epithalamin, which has been shown to potentially increase lifespan in rats and mice. A human study found that Epithalamin-treated patients registered a 1.6-1.8-fold mortality decrease compared to the control group. [R] [R]

Epithalon was first discovered in Russia in the 1980s. Professor Vladimir Khavinson, who discovered it, had previously extracted epithalamin from bovine pineal glands.

The difficulty of extracting the natural polypeptide in large amounts led him to create a synthetic version.

Research shows that Epitalon reproduces the effects of Epithalamin. In particular, Epitalon prolongs the lifespan of mice and fruit flies. This synthetic peptide also restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys. [R]

How does Epithalon Work?

Epithalon has the following working mechanisms:

May Increase the Production of Telomerase

Telomerase is an enzyme found at both ends of each chromosome. Research has shown that it may reverse the aging process. [R]

Telomerase increases the production of telomeres, caps that protect the end of chromosomes. Every time cells divide, their telomeres shorten, which eventually prompts cells to stop dividing and then die. Telomerase prevents this decline in some kinds of cells, including stem cells, by inducing telomere elongation.

May Eliminate Free Radicals

An animal study suggests that Epitalon peptide is a potent antioxidant, comparable to melatonin, which may confer longevity benefits. [R]

In a separate study, it was found that peptide preparations from the pineal gland (Epithalamin and Epitalon) may possess antioxidant properties exceeding, in some cases, the effects of the well-known scavenger of reactive oxygen species (ROS), melatonin. [R]

Regulate DNA

Aside from the potential increases in the production of telomerase and eliminating free radicals, Epithalon also changes the expression of specific genes.

Research has shown that Epithalon regulates the expression of genes functionally, belonging to different cell systems. This synthetic peptide has been found to interact with DNA sites located in the promoter zones of genes encoding CD5, IL-2, MMp2, and Tram1 signal molecules. [R]

Epithalon Research

Multiple clinical studies have been conducted on Epithalon to date. This synthetic peptide has also attracted several animal and cell-based studies. Still, further research is needed to verify the effects of the synthetic pineal peptide Epitalon.

PureRawz sells Epithalon for laboratory and research use only.

Epithalon and the Potential Implications on Aging

Gene therapy has shown that mouse lifespan could be extended up to 24% by inducing cells to express telomerase. The therapy furthermore produced an appreciable improvement in the animal’s health, delaying the onset of age-related diseases like osteoporosis and insulin resistance. [R]

Similar results were obtained in a clinical study. Epithalamin-treated patients registered a 1.6-1.8 fold decrease in mortality compared to control group members. A separate group of patients treated with Thymalin, combined with Epithalamin, registered a 4.1-fold decrease in mortality. [R]

In vitro experiments, meanwhile, suggest that Epitalon can delay the aging process of oocytes in vitro via modulating mitochondrial activity and ROS levels. [R]

Epithalon and The Potential Effects on Age-Related Diseases

In the gene therapy mentioned above, Epithalon was found to produce an appreciable involvement in the animal’s health. Administration of this synthetic peptide was associated with potential delays of the onset of age-related diseases, such as osteoporosis and insulin resistance.

In the clinical study, restoration of homeostasis was accompanied by a 2.0-2.4-fold decrease in hypertension, osteoporosis, acute respiratory disease incidence, reduced incidence of ischemic heart disease clinical manifestations, and deforming osteoarthritis compared to the control group.

Epithalon and Potential Future Implications on Skin Health

As stated above, Epithalon regulates the gene that in turn regulates MMP2. MMP2 plays an essential role in angiogenesis, inflammation, and fibrosis, processes that are critical for wound healing. [R]

Another possible route Epithalon could take to improve skin health is by decreasing caspase-3 activity. Caspase-3 is an enzyme implicated in cell apoptosis (cell death). The reduction in caspase-3 production enables Epithalon to protect skin cells, keeping them healthy and alive for extended periods. [R]

However, future research is needed to verify the effects of the synthetic pineal peptide Epithalon.

Epithalon and Melatonin

Melatonin, aka the sleep hormone, is produced by your mind in response to darkness. Research shows that the benefits of this hormone extend well beyond sleep. Low melatonin levels can result in insomnia, restlessness, poor stress response, and other conditions.

In two separate studies, Epitalon supplementation stimulated melatonin production in elderly subjects with pineal gland dysfunction and old rats. There is preclinical evidence that Epithalon may have potentially increased melatonin levels in adult rats, as well as in culture medium. [R] [R]

Epithalon and Tumor Growth

Data from a mice study demonstrate the inhibitory effect of Epitalon in the development of spontaneous mammary tumors in HER-2/neu mice. The intensity of HER-2/neu mRNA expression in breast tumors of Epithalon-treated mice was 3.7 times lower than in control animals. [R]

In another study, the effect of Epitalon on spontaneous carcinogenesis in C3H/H3 mice was investigated. Treatment with Epitalon slowed down the development of metastases from spontaneous tumors. This data highlights the effect of Epitalon as part of its oncostatic properties. [R]

Epithalon is currently being investigated as a potential treatment for Her-2/neu-positive breast cancers. HER2 cancer occurs in 1 out of every 5 breast cancers worldwide. Health experts claim that it is more aggressive than other types of breast cancer. [R]

Further research to provide an indication of the safety and efficacy of Epithalon as a cancer treatment aid could have massive implications on how cancer treatment is approached.

Epithalon and Potential Treatment of Conditions Related to Eyesight

A study was conducted to investigate the effects of Epitalon on the course of congenital pigmentary degeneration of the retina. Epitalon therapy in patients with degenerative retinal lesions results in a positive clinical effect in 90% of the cases. [R]

Where to Buy Epithalon Online

PureRawz is the best place to buy Epithalon online.

In order to be the best research chemicals supplier, we provide reference materials with every product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers say about our products and great customer service.

Epithalon Summary

Epithalon peptide, a synthetic version of the polypeptide Epithalamin, has been shown to potentially increase lifespan in rats and mice. This synthetic peptide has also shown promising research results on inhibiting tumor growth, increasing melatonin production, and suppressing the onset of age-related diseases in mice.

Epitalon for sale at PureRawz is for research purposes, testing, and laboratory experimentation only, not for human consumption.

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human usage.

19 reviews for Epithalon

  1. User Avatar: Joe Harpers

    Joe Harpers

    I have been purchasing this for a while now, and I am not planning on getting it anywhere else. You guys are a fantastic team.

  2. Seth

    This product is really convenient for a man that is in his late fifties here, the customer service you guys offer is always welcoming.

  3. Anonymous

    I have found that every product I have used from you guys is impressive and I never had regrets. Prices are good!

  4. Dennis O’Parker

    50 is just a number! This product helps me to feel younger, more energy and positivity.

  5. Jack Hero

    I want to stay young forever! 🙂 I will keep buying this to keep it that way. Customer service is really fast and helpful.

  6. Billy E. Crawford


  7. Byron

    I felt my recovery times improve, also added some muscle mass.

  8. Randy G

    Great value for its quality. It’s working well for my research so far.

  9. Greyson T

    I’ve been using this for a few weeks and I feel younger, have more energy and I sleep better!

  10. Colin Sweeney (verified owner)

    Love this stuff! Will be reordering again!

  11. Leroy Combs

    It’s been a game-changer for my skin, making it smoother and reducing those pesky fine lines, my energy levels have skyrocketed, and I feel more vibrant than ever. Plus, it’s great for boosting immunity, keeping those nasty bugs at bay.
    Highly recommend!

  12. Wes Heath

    provided a noticeable boost in energy and vitality. Skin and hair also improved. Impressed with the benefits.

  13. Verified Buyer (verified owner)

    Shipping was a little slow but not bad. No need to question the quality. Seems like top notch stuff.

  14. Josh (verified owner)

  15. Barbara S. (verified owner)

  16. clark (verified owner)

  17. Frank D. (verified owner)

  18. Richard S. (verified owner)

    Great product

  19. Anonymous (verified owner)

    If you know you know… If you don’t please don’t research because I don’t want the price going up again on this 😂

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