🔥 WE HAVE THE BEST COMPOUNDS ON THE PLANET
🔥 WE HAVE THE BEST COMPOUNDS ON THE PLANET
Researchers and investigators are always on the hunt for research compounds that give them insight into the chemical world. They look for research substances that may hold beneficial information in a research context. The two compounds that come into the limelight for this purpose are: MK-677 and RAD-140.
In today’s blog, we will learn about the differences between these compounds. We’ll also take a look at what makes them different from each other and which compound is better!
MK-677, also known by the name Ibutamoren, is a growth hormone secretagogue. A lot of people who are not familiar with MK-677 may confuse it with SARM. However, it is not a SARM! Due to its properties, such as muscle growth and increased muscle mass, the compound is often mistaken for one.
A study on MK-677 has found that it works by mimicking the ghrelin receptor. The same study has also suggested that MK-677 binds to the ghrelin receptors in the brain of research subjects.
When this interaction takes place, it stimulates the natural release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) [1] [2]. These hormones play a key role in muscle growth, tissue repair, and bone density in research subjects.
RAD-140, also known as Testolone, is a SARM (Selective Androgen Receptor Modulator). Researchers found this compound interesting as they studied it for its potential to increase muscle mass and strength [3].
Rad-140 has been shown to work by selectively targeting androgen receptors in bone and muscle tissues in research settings. Researchers have found that RAD-140 activates these receptors and promotes anabolic activity without offering side effects associated with anabolic steroids. [4]
Till now, you may have known the difference between MK-677 and RAD-140. However, if there is still some confusion, then have a look at the following table.
| MK-677 | RAD-140 |
| A growth hormone secretagogue | Selective androgen receptor modulator (SARM) |
| Non-peptide ghrelin receptor agonist | Non-steroidal androgen receptor agonist |
| It has the potential to stimulate GH and IGF-1 by activating the ghrelin receptor | It may potentially bind to androgen receptors to promote anabolic activity |
| It may potentially act on the Endocrine (GH/IGF-1 axis) | It may potentially act on the androgenic receptors in bone and muscle tissues |
| It is not a SARM | It is classified as a SARM |
| It is also known by the name Ibutamoren | It is also known by the name Testolone |
| It may potentially offer muscle growth and enhancement by an Indirect approach (via GH/IGF-1) | It may potentially offer muscle growth effects by directly targeting androgen receptor binding. |
| Studies have found that it does not suppress hormones | A few studies have observed that it may suppress testosterone levels in research subjects |
| Researchers have found its typical cycle length is from 8 – 12 weeks in various research studies | The cycle length of RAD 140 is 6 – 10 weeks in various research studies |
| Researchers study this compound for its potential role in muscle wasting, aging, GH deficiency, and metabolic studies | Researchers study this compound for its potential role in muscle wasting, hormone replacement, and performance enhancement studies |
| Just a research compound, not FDA approved | Just a research compound, not FDA approved |
Both MK-677 and RAD 140 have particular benefits. A few of the benefits that researchers have so far studied are as follows:
Researchers are closely observing the side effects of MK-677 and RAD-140. Though long-term research is still needed, so far, they have found the following side effects in different research settings:
The best option for laboratory research depends on the specific objective and goals. Researchers study MK-677 for its potential to stimulate growth hormone and IGF-1 levels. Moreover, they investigate MK-677 due to its anti-aging, bone density, and muscle preservation effects in research settings.
On the other hand, RAD-140 (Testolone) is a selective androgen receptor modulator (SARM). It is primarily studied for its anabolic effects, with applications in muscle wasting, strength enhancement, and hormone replacement models.
While MK-677 is favored for longevity and hormonal studies. RAD-140 is ideal for androgenic and muscle-related research.
Therefore, the best compound depends on whether the research is focused on hormonal/aging pathways (MK-677) or androgenic/anabolic performance (RAD-140).
MK-677 acts through the endocrine system, whereas RAD-140 functions through androgenic pathways. While many aspects of both compounds are the same, they are different from each other in terms of their working mechanism.
Both MK-677 and RAD-140 enhance muscle growth, boost recovery, and improve bone density in different research studies. However, MK-677 is a growth hormone secretagogue that stimulates the ghrelin receptor to increase levels of growth hormone and IGF-1.
In contrast, RAD-140 (Testolone) is a selective androgen receptor modulator (SARM). It directly binds to androgen receptors in muscle and bone tissue to promote anabolic effects like increased strength, muscle mass, and fat loss. However, RAD-140 may suppress natural testosterone production.
Researchers believe RAD 140 is generally more effective for fat loss due to its androgenic effects. Whereas, MK-677 primarily promotes muscle gain and recovery.
Yes, MK-677 often increases appetite and may cause mild water retention due to elevated growth hormone levels as observed in research settings.
Limited data exist, but combining RAD 140 with other androgenic compounds increases the risk of hormonal imbalance.
In research settings, MK-677 (Ibutamoren) is the compound primarily studied for potential anti-aging effects. That is because it stimulates the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). In contrast, RAD-140 (Testolone) is mainly researched for its anabolic properties, particularly in muscle wasting and testosterone replacement models.
Disclaimer: Remember, MK-677 and RAD-140 are research compounds. These compounds are not intended for human use. Therefore, it is recommended to approach them carefully after consulting your health care specialist.
A., Tchesnokov, A., & Hattersley, G. (2010). Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Medicinal Chemistry Letters, 2(2), 124–129. https://doi.org/10.1021/ml1002508
Team Purerawz provides simple and research-based information on SARMs, Peptides, Nootropics, Kratom and Stacks. Our writers and researchers make sure each article is clear, accurate, and easy to understand. We aim to help labs, students, and science enthusiasts find the right compounds for their research.
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