What is DSIP?

Delta sleep-inducing peptide (DSIP) is a neuropeptide that was first detected in the rabbit brain in 1963. In 1977, the peptide was isolated from cerebral venous blood for the first time. Subsequent research has shown that DSIP is normally synthesized in the hypothalamus. [R]

Research has shown that DSIP is present in small amounts in the blood. Its levels vary throughout the day and are higher in the afternoons. This peptide has also been found in relatively high concentrations in human milk, with values ranging from 10 ng m/L to 30 ng m/L. [R]

Preclinical studies have shown that it can cross the blood-brain barrier. DSIP has also shown the ability to be readily absorbed by the gut without being denatured by enzymes. Furthermore, it has been established that it causes mild side effects and no withdrawal symptoms. [R]

In a clinical study, the administration of DSIP increased sleep duration and reduced sleep disturbance and latency in people with insomnia. Another study reported that this neuropeptide reduced sleep onset and increased sleep duration and efficiency in healthy adults. [R]

 

How does DSIP Work?

Until now, various effects of DSIP have been reported, including:

 

1) Increases delta-wave activity in the brain

DSIP got its current name because of its delta-wave (-sleep) increasing effect. This effect was first observed in rabbits and later reported in rats and mice. Delta waves are the slowest recorded brain waves. They are associated with the deepest levels of restorative, healing sleep. [R][R]

 

2) Increase rapid-eye-movement sleep

In a preclinical study involving cats, DSIP was reported to produce a more pronounced increase in rapid-eye-movement sleep than in delta sleep. REM sleep is a stage of sleep during which your eyes move around rapidly. It is associated with dreaming and memory consolidation. [R][R]

 

3) Increase non-REM sleep

In a pilot study investigating the sleep-inducing capacity of DSIP in humans, this neuropeptide produced enhancements in non-REM as well as REM sleep. Researchers have proposed that abnormalities in NREM sleep may play a role in Alzheimer’s and Parkinson’s disease. [R][R][R]

 

4) Increases slow wave sleep

A preclinical study reported a significant increase in slow wave sleep (SWS) in cats following DSIP administration. SWS consists of stage three of NREM sleep and usually lasts between 70 and 90 minutes. Your body is at its most restful during this stage of sleep. [R]

 

DSIP Research

What follows is a summary of the existing research on the DSIP peptide. The information given in this section is for educational purposes only. It doesn’t constitute medical advice. Pure Rawz sells DSIP for laboratory, educational, and scientific research purposes only.

 

1) DSIP and Insomnia

In a double-blind, placebo-controlled study, DSIP injections (30 nmol/kg body weight) increased sleep time by 22.5% compared with baseline. The treatment increased sleep efficiency by 26.8% and reduced sleep latency and awakening after sleep onset by 53% and 45%, respectively. [R]

Another study investigated the effects of DSIP treatment on chronic insomniac patients. It was reported that the DSIP group experienced higher sleep efficiency and shorter sleep latency compared to the placebo. One measure of subjectively estimated tiredness decreased within the DSIP group. [R]

A separate study reported that 6 out of 7 patients with severe insomnia had a normalized sleep after receiving 10 DSIP injections within 14 days. [R]

 

2) DSIP and Normal Sleep

Three phase 1 studies investigated the effects of DSIP treatment on healthy volunteers. Final results indicated that DSIP enhanced sleep, retained effects on sleep functions up to 20 hours post-injection, and was well tolerated with no side effects. [R][R][R]

A preclinical study showed DSIP increased some sleep patterns (i.e., SWS). DSIP was found to produce a significant increase in deep slow wave sleep (S2), while light slow wave sleep (S1) was significantly decreased. REM and NREM sleep cycles remained unaffected. [R]

 

3) DSIP and Schizophrenia

A clinical investigation compared cerebrospinal fluid levels of DSIP in healthy volunteers and patients with schizophrenia. That is because DSIP neuropeptide has been shown to have direct effects on the central nervous system functioning in various mammals. [R]

Results from the study show that patients with schizophrenia had significantly lower CFC levels of DSIP than the healthy volunteers. [R]

 

4) DSIP and Major Depressive Disorder

The above clinical investigation also compared the CFL levels of DSIP in healthy volunteers and patients with major depressive disorder. Just as it was with schizophrenia, patients with MDD had significantly lower CSF levels of DSIP than healthy volunteers. [R]

Significantly, the levels of DSIP in CSF tended to be inversely correlated to the sleep disturbance scores in depressed patients. [R]

Another study investigated the levels of plasma DSIP in suicidal patients with MDD. It reported significantly elevated DSIP levels in MDD patients. A significant correlation was also established between cortisol (aka the “stress hormone”) and DSIP levels in healthy controls. [R]

 

5) DSIP and Narcolepsy

Narcolepsy is a chronic neurological disorder characterized by daytime drowsiness and sudden bouts of sleep. People with narcolepsy can fall asleep anywhere, anytime, without clinical or laboratory signs.

A researcher investigated the effects of DSIP on a male narcoleptic. Repeated injections of this sleep-inducing peptide, either in the evening or in the morning, were associated with enhanced daytime activity. The frequency of sleep attacks was also reduced, and daytime performance increased. [R]

 

6) DSIP and Pain

In a clinical study, 6 out of 7 patients suffering from chronic pain syndromes responded well to DSIP therapy. The patients were feeling different types of discomfort. These included migraine headaches, vasomotoric headaches, foot pain of psychogenic origin, and tinnitus. [R]

All the patients were required to report their pain perception on a visual analog scale. Except for one patient with migraine, all others reported reduced pain and improved mood. The changes (significantly reduced pain perception) persisted for up to 91 days. [R]

 

7) DSIP and Drug Abuse

According to a clinical study with 41 opiate addicts and 47 alcoholics, 97% of the opiate and 87% of the alcoholic patients were successfully treated with DSIP-injected IV. Significantly, the DSIP treatment was considered superior to the usual withdrawal treatments. [R]

 

8) DSIP and Blood Pressure

A preclinical study investigated whether DSIP could regulate blood pressure. Final results indicated that DSIP treatment decreased control rats’ heart rate blood pressure level. However, it had no such effect on the already depressed level of blood pressure in the other group. [R]

 

9) DSIP and Somatostatin

Somatostatin is a protein that inhibits muscle growth. In one preclinical study, DSIP inhibited somatostatin release via a dopaminergic (related to dopamine) mechanism in muscle cells. [R]

 

Where to Buy DSIP Online?

Pure Rawz is the best place to buy the highest-quality DSIP online.

In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. We sell liquid, powder, and capsule high-quality TUDA formulations. All the formulations are equally high-quality.

 

Summary

DSIP has demonstrated the ability to influence sleep-wake cycles, increase sleep duration, and reduce sleep onset in insomniacs as well as healthy adults. However, its effects aren’t limited to just sleep. It may also significantly reduce pain perception in patients with chronic pain of various origins.

Pure Rawz sells DSIP for laboratory and research purposes only.

Please note, packaging might differ slightly as we update our packaging and labels. Please research the scientific uses of this product and read our TERMS AND CONDITIONS before completing your purchase.
By completing and paying for your order, you agree to our Terms and Conditions.  Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at support@purerawz.co