What Is Hexarelin?

It is a synthetic growth hormone (GH) releasing peptide. In terms of structure, Hexarelin is a hexapeptide, meaning it is made up of a 6 amino acid sequence. Amino acids are the building blocks of peptides and, by extension, proteins in the body.

A clinical study has shown that Hexarelin can stimulate profound GH release after oral, intranasal, IV, and subcutaneous administration. Growth hormones control various functions in the body. They regulate body fat, build bones and muscles, and influence height. [R]

GH levels increase during childhood and peak during puberty, before naturally reducing from middle age onwards. Symptoms of reduced GH levels or GH deficiency include reduced bone strength, lack of concentration, bouts of anxiety or depression, and lack of concentration. [R]

Hexarelin Vs Ipamorelin

Hexarelin and Ipamorelin are research peptides. Both of them are growth hormone secretagogue receptor (GHSR) agonists. Both mimic the action of ghrelin, a naturally occurring hormone that controls hunger, protects cardiovascular health, and causes GH release.

However, both of them are different in several key aspects. The first is structure. While Ipamorelin has 5 amino acids in its chain, Hexarelin has 6. They also have different half-lives. Ipamorelin has a half-life of 2 hours, compared to 55 minutes to that of Hexarelin.

PureRawz sells Hexarelin for research purposes and not for veterinary or human consumption.

How does Hexarelin Work?

These are different mechanisms through which Hexarelin stimulates GH release:

1) Activates the GH Secretagogue Receptor

Research has shown that it binds to and activates the growth hormone secretagogue receptor (GHSR) in the brain. This results in increased GH release in the body.

An animal study highlights three mechanisms with which Hexarelin stimulates GH secretion in vivo. These include direct action on the pituitary gland; an indirect action that involves the release of GH-releasing hormone (GHRH); and the release of a still unknown hypothalamic factor. [R]

2) Inhibits Hypothalamic Somatostatin Release

Somatostatin is a hormone produced naturally in multiple locations in the body. It is involved in a variety of functions, including the inhibition of growth hormone (GH) release in the endocrine system. Thus, by inhibiting its release, Hexarelin causes increased GH secretion. [R]

A study was conducted to analyze the interaction of Somatostatin with it. It showed that SS and Hexarelin counteract their respective inhibitory and stimulatory action on GH secretion. [R]

Hexarelin Research

Multiple animal studies have been conducted on Hexarelin to date. This research peptide has also attracted quite a few number of human trials. These studies have established that this peptide may potentially have the ability to increase growth hormone production in research subjects.

It doesn’t affect luteinizing hormone (LH), follicle-stimulating hormone (FSH), or plasma levels of glucose in humans.

Pure Rawz offers Hexarelin 5mg and 2mg for research purposes only.

1) Hexarelin and Growth Hormone

A clinical trial was conducted to assess the impact of Hexarelin on GH release following oral, intranasal, subcutaneous, and iv administration. Twelve healthy elderly subjects with a median age of 68 (age range 68 – 81 years) were entered into the study.

Results showed that it is capable of causing significant GH release in healthy subjects after oral, intranasal, subcutaneous, and IV administration. Total body fat, lean body mass, and bone mineral density did not change compared with baseline. [R]

2) Hexarelin and IGF-1

Another study was conducted to determine whether healthy adult subjects would remain responsive to short-term, intermittent treatment with it. It was also investigated whether this treatment would result in an increase in serum insulin-like growth factor 1.

Results from the study indicated that chronic but intermittent treatment with Hexarelin does not desensitize the GH response to the peptide. Moreover, following the treatment, a trend toward increase was shown for IGF-1 and IGFBP-3 levels. [R]

In another study, twice or three times daily intranasal administration of it to children with short stature and normal GH secretion evolved a significant rise in IGF-1. There was also a significant, within normal limits, rise in thyroid-stimulating hormone. [R]

3) Hexarelin and Heart Health

Research has shown that it has cardioprotective activity in common cardiovascular conditions, such as cardiac fibrosis, ischemic heart disease, cardiac dysfunction, and atherosclerosis. These beneficial effects seem to be mediated through the binding and activation of cardiac receptors.

In different animal studies, this hexapeptide has improved cardiac function and decreased peripheral resistance, promoted survival of cardiac muscle cells, and alleviated the development of atherosclerosis. One human study found that it increased left ventricular ejection function (LVEF). [R]

Since it has more potent cardiac effects than its natural analog ghrelin, it can be a potential ghrelin alternative as a promising therapeutic agent for the treatment of cardiovascular diseases.

4) Hexarelin and Muscle Growth

Research has shown that growth hormone increases muscle mass and strength. [R]

In a rat model of cisplatin-induced cachexia, Hexarelin and another growth hormone secretagogue protected skeletal muscle from mitochondrial damage. Cachexia is a severe syndrome characterized by loss of skeletal muscle and fat mass, often associated with cancer. [R]

5) Hexarelin and Fat Loss

In GH-deficient adults, GH treatment appears to lead to a net loss of fat tissue. GH treatment trials in the elderly show significant increases in lean body mass and smaller decreases in fat mass. [R]

An animal study has shown that Hexarelin increases pulsatile GH secretion, reduces fat mass, and improves lipid profile. That too without compromising glucose metabolism. The study also demonstrated that it has potent orexigenic (having a stimulating effect on the appetite) effects. [R]

6) Hexarelin and Prolactin

Prolactin is a hormone made by the pituitary gland. It has hundreds of functions in the body, but the main ones include milk production in females. In women, prolactin deficiency could lead to a lack of milk production. [R]

Research has shown that Hexarelin stimulates prolactin secretion in men with acromegaly (excessive GH production syndrome), but not in hyperprolactinaemic (those who already have higher-than-normal levels of prolactin in their blood) patients. [R]

Hexarelin FAQs

Is Hexarelin a GHRP?

Yes. It belongs to the family of growth hormone-releasing peptides. Other members of the GHRP family include Ipamorelin, CJC-1295, and Sermorelin.

What is The Half-Life of Hexarelin?

Hexarelin is estimated to have a half-life of 55 minutes.

Where to Buy Hexarelin Online

PureRawz is the best place to buy Hexarelin for sale.

In order to be the best research peptides supplier, we provide reference materials with every product we sell. Each of our products comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to check out what existing customers say about our products and great customer service.

Summary

Hexarelin is a potent GH releasing peptide. It stimulates GH release by mimicking the action of ghrelin in the body. It also induced an increase in IGF-1 levels in research subjects. Multiple studies have also demonstrated that it possesses cardioprotective effects.