Description

LGD-4033 + MK-2866 + MK-677 Formula

What is LGD-4033 + Ostarine + MK-677 Formula?

SARMs and Growth Hormone Secretagogues are often combined formulas as an alternative to common anabolic chemicals [R]. The combination of SARMs and skeletal muscle androgenic hormones may boost muscle growth and strength. This strategy might lessen androgenic adverse effects like aggressiveness, hair loss, and acne. This combination makes it easier for researchers to conduct studies on various scenarios. It may help keep lean muscle mass and reduce fat mass. Additionally, the formula may increase bone mineral density. It also facilitates quicker healing periods.

Now, imagine the benefits brought by Ostarine and MK-677 reformulated by staggering another SARM, Ligandrol. This staggered formula impacts body composition twice as much. It may boost muscle-building potential while aiding in fat loss to prevent a calorie deficit. The combined formulas also increases natural growth hormone production. This hormone helps with muscle mass gain and fat loss and improves hair, skin, and sleep quality.

Purerawz LGD-4033 + Ostarine + MK-677 Formula contains a blend of LGD4033, Ostarine, and MK677. Available in tablet, capsule, and liquid forms:

• Tablets: 75 mg per tablet (25 mg LGD-4033, 25 mg Ostarine, and 25 mg MK-677) Available in 20 tablets (1500 mg) and 40 tablets (3000 mg)
• Capsules: 75 mg per capsule ( 25 mg LGD 4033, 25 mg Ostarine, and 25 mg MK-677), totaling 3000 mg.
• Liquid: 100 mg per ml (33.3 mg LGD-4033, 33.3 mg Ostarine, and 33.3 mg MK-677), totaling 3000 mg in a 30 ml bottle.

SARMs

SARMs is an abbreviated name for a group of synthetic compounds. These compounds are designed to act as a natural ligand to the abundant androgen receptor (AR) [R]. Selective Androgen Receptor Modulators (SARMs) target AR proteins that play a pivotal role in the body’s response to androgens. Androgens are hormones like testosterone [R]. These receptors initiate a wide range of biological activities, including changes in body composition. They also contribute to the development and maintenance of male characteristics, reproductive function, and sexual health. Intramuscular androgen receptors exhibit a high degree of specificity towards their target tissues. This allows them to accurately affect the cells with which they participate, resulting in broad biological outcomes [R] [R].

SARMs are non-steroidal and exhibit a wide range of structural diversity. This helps them target tissues more precisely. Thus, they lower the danger of steroid adverse effects such as liver damage and cardiovascular difficulties. SARMs are mostly expressed in neurons, notably in the CNS. This indicates the role of SARMs in neuroprotection, which is vital for maintaining cognitive function and overall brain health [R].

Ostarine, a well-known SARM, is frequently combined with other SARMs like Ligandrol to enhance its effects. When studied together, this potent formula may potentially boost muscle growth. It also enhances muscular strength while minimizing androgenic side effects.

What is Ligandrol

CAS number	1165910-22-4
Molar Mass	338.25 g/mol
Chemical Formula	C14H12F6N2O
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Ligandrol, also referred to as LGD-4033, is a small-molecule drug. It selectively acts as an agonist or antagonist on AR throughout the body. It is a nonsteroidal, oral SARM. It binds to AR with exceptionally high affinity (Ki around 1 nM) and selectivity [R].

LGD-4033’s name reflects its ability to bind to and activate AR. This influences gene expression and produces tissue-specific effects. It was initially developed to address muscle wasting, osteoporosis, and age-related muscle loss. It also demonstrated significant anabolic effects in animal muscle tissue. Both anti-resorptive and anabolic effects were seen in bone. The findings indicated an obvious inclination towards muscle tissue in comparison to prostate tissue [R] [R]. The safety and efficacy of LGD-4033 were established. The treatment demonstrated a favorable tolerance profile across a range of dosages during extended administration. The suppression of total serum testosterone levels and sex hormone-binding globulin levels occurred in a dose-dependent manner, as demonstrated by the observed increase in lean body mass of the test subject [R].

The phase II clinical trial on Ligandrol, registered as VK521, has demonstrated that LGD-4033 may help increase muscle mass without adding fat [R]. This makes Ligandrol one of the few SARMs with scientific case reports from human studies supporting its effectiveness. As a result, Ligandrol is highly appealing to a wide range of users. These users have diverse goals, including, improving recovery and enhancing body composition.

How does LGD-4033 impact body composition?

SARMs in general may target different tissues due to the wide distribution of AR in the body. However, the molecular structure of a specific SARM may explain why they differ in their vast array of benefits. These benefits [R] include promoting skeletal muscle growth, reducing prostate size, and inhibiting breast cancer growth. Importantly, they do this without significant systemic side effects. This makes them a very promising drug for research [R] [R].

As a SARM, Ligandrol acts similarly to AR’s natural ligand, the androgen. It forms a transcriptional regulator complex with the nuclear AR. The resulting structure starts a signaling chain [R]. Like steroids, LGD-4033 binds strongly to the androgen receptor. Since it is a mild prostate agonist, it is often used for bulking.

It enhances muscle strength and hypertrophy without causing the androgenic effects associated with testosterone and other anabolic steroids. This helps prevent prostate hyperplasia [R].

As a SARM, LGD-4033 exhibits tissue-selective effects that depend on its unique molecular interactions with the AR [R]. An important AR binding affinity has been shown in animal experiments. These studies show it may improve bone and muscular growth. LGD-4033 also supports muscle over the prostate [R].

Ligandrol may:

• May enhance bone health in test subjects with osteoporosis [R] [R] [R] [R].
• It may improve muscle lean mass, strength, and hormone levels to help aged test subjects [R] [R] [R].
• It may be helpful in treating muscle loss in older test subjects [R].
• It may accelerate recovery from hip fracture [R] [R].
• It may help reduce prostate enlargement and associated symptoms [R]

What is Ostarine?

CAS number	841205-47-8
Molar Mass	393.4 g/mol
Chemical Formula	C19H14F3N3O3
IUPAC Name	(2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

Ostarine, or MK-2866, is one of the well-characterized SARMs designed to mimic the effects of testosterone [R]. It was patented under the name of Enobosarm in 2005. The compound has been under development as a potential treatment for muscle wasting. It is continuously being evaluated in at least 25 clinical studies [R].

Ostarine may contribute to muscle development by acting like testosterone. It can help maintain libido and fertility while supporting prostate health [R]. Furthermore, it has the potential to address muscle loss linked to conditions such as cancer cachexia [R]. Research has indicated its potential advantages for skeletal health, particularly in facilitating bone repair in ovariectomized rats. This indicates that Ostarine may serve as a beneficial alternative for osteoporosis, even in the absence of bone fractures [R] [R].

How does Ostarine work?

Ostarine exhibits a similar mechanism of action to Ligandrol. It binds with androgen receptors (AR) that are highly concentrated in muscle and bone tissues [R]. There are two theories explaining the molecular mechanisms responsible for the specific effects of SARMs. The first is that SARMs possess higher tissue specificity. They also have more favorable pharmacokinetics due to their resistance to aromatization or 5-α-reduction [R] [R]. Second, a variety of coactivators and corepressors may affect SARM-activated AR. These molecules are recruited during contact and regulate receptor function. The specific combination and balance of these coactivators and corepressors can vary depending on the type of SARM. They can also differ based on the tissue in which the SARM is acting and the individual’s unique biological makeup. This complexity helps explain why different SARMs can have distinct effects on muscle growth. It also accounts for variations in strength and side effects [R].

Ostarine may act as:

• It may help prevent muscle loss related to cancer and other health issues. [R]
• It may act as a potential treatment for Metastatic Triple-Negative Breast Cancer [R][R]
• It may also act as a potential treatment for Atrophic Muscular Disorders [R]
• It may act as an alternative therapy for metabolic complications in AR-deficient test subjects [R]
• It may aid in weight management by lowering cholesterol and improving physical performance. [R] [R] [R]
• It may be a promoter of lean body mass synthesis [R]
• It may act as an alternative medicine for diabetic patients [R]
• It may improve cardiac health [R]

What is MK-677?

CAS number	159752-10-0
Molar Mass	624.8 g/mol
Chemical Formula	C28H40N4O8S2
IUPAC Name	2-amino-2-methyl-N-[(2R)-1-(1-methylsulfonylspiro[2H-indole-3,4′-piperidine]-1′-yl)-1-oxo-3-phenylmethoxypropan-2-yl]propanamide;methanesulfonic acid

MK-677 (Ibutamoren mesylate or L-163,191) is a nonpeptide growth hormone secretagogue (GHS). It belongs to a class of compounds that stimulate the release of growth hormone. Unlike SARMs, GHSs act through a different mechanism. They target the G protein-coupled receptor (GPCR), specifically the growth hormone-stimulating receptor (GHS-R)[R]. MK-677 can withstand the acidic conditions of the oral route [R]. This likely contributes to its great oral availability. It acts as a functional agonist of the putative GHRP receptor. It exhibits endocrine effects similar to those of GHRP and acts as a ghrelin mimetic [R][R]. This demonstrates potential benefits for appetite regulation, growth hormone stimulation, and body composition. MK-677 may help manage short-term hunger, increase growth hormone secretion, and promote muscle growth and bone development through the release of insulin-like growth factor-1 [R].

How does MK-677 work in the androgenic hormone?

MK-677 functions as a competitive agonist of ghrelin. Ghrelin is a hunger hormone produced in the stomach that acts as the natural ligand for the GHS-R [R]. The MK-677-activated GR initiates the stimulation of multiple signal transduction pathways. This includes the GH-secretagogue receptor, which results in the synthesis of GH [R] [R]. GH is a multifunctional hormone that regulates the body’s overall cell growth, carbohydrate-protein serum lipid profile, and water-electrolyte balance [R]. For this reason, MK-677 indirectly increases GH production. This could be an effective therapeutic target for enhancing degenerated cognitive function and weight loss [R].

The increased GH in the bloodstream sends a signal to the liver. This initiates the release of insulin-like growth factor 1 (IGF-1). IGF-1 serves as a trigger for anabolic activities in peripheral tissues, particularly skeletal muscle. This process initiates various downstream intracellular pathways that may enhance the body’s overall structure [R]. MK-677 has a half-life 12 times longer than ghrelin. This may contribute to its higher efficacy and increased levels of growth hormone and IGF-1, significantly impacting osteoblast formation [R].

MK-677 may help in:

• It may help treat muscle loss caused by reduced growth hormone, muscular atrophy, and poor nutrition [R].
• It may initiate temporary weight loss and enhance lean muscle mass [R][R].
• It may prevent muscle loss from low-calorie intake [R].
• It may enhance sleep quality by stimulating deep sleep and increasing GH production. [R][R][R]
• It may initiate bone remodeling and increase several serum biomarkers associated with both bone breakdown and formation in older individuals [R].
• It may prevent signs of aging by reverting the normal GH production [R][R].

FREQUENTLY ASKED QUESTIONS

Why choose formulas with both androgen receptor content and growth hormone for muscle research?

Formulas incorporating androgen receptor modulators, such as LGD-4033 and Ostarine, in conjunction with a growth hormone secretagogue like MK-677, are optimal for muscle research. They address two fundamental pathways essential for muscle growth and repair. Activation of the androgen receptor facilitates anabolic processes within muscle tissues. This activation enhances muscle growth and strength. Concurrently, elevated levels of growth hormone and IGF-1 contribute to improved recovery. They also aid in tissue repair and protein synthesis. This combination provides a comprehensive approach to studying muscle development and regeneration. It is more effective than targeting either pathway alone.

Where to buy the best SARM skeletal muscle androgenic hormone formulas for sale?

PureRawz is one of the top suppliers of potent SARM formulas, such as LGD-4033 + Ostarine + MK-677. You can also buy LGD-4033, Ostarine, and MK-677 separately at PureRawz. PureRawz offers other popular SARMs, such as LGD 4033 and MK677 SARM formula. We also provide additional product information with publication types that may help researchers with new findings or create new survival supplements.

To produce a quality item, we carry the item’s reference materials with every product we sell. Each of our ingredients comes with a third-party lab-issued Certificate of Analysis for identification and purity. PureRawz provides a scientific-based product overview of the SARMs combined formulas for your research needs.

If you are looking for the best place to buy the LGD-4033 + Ostarine + MK-677 formula, we offer free, fast shipping in the USA and worldwide on orders above $100. You can pay for your cart purchase using various methods, including PayPal and Bitcoin. Click on the ‘Reviews’ tab to see what existing customers say about our products. This section may help address any questions you have about SARMs.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with the appropriate IRB oversight. All preclinical research must be conducted with relevant IACUC following the AWA guidelines.

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