Description

LGD-4033 + RAD-140 + S23 Formula

What is LGD-4033 + RAD-140 + S23 Formula?

SARMs are synthetic compounds designed to act as natural ligands for the abundant androgen receptor (AR). This receptor initiates a diverse array of biological activities. It is critical to normal sexual development and function. SARMs have higher specificity for target tissues[R] [R]. Their expression is concentrated in neurons, especially in the CNS. This is why SARMs play a critical role in neuronal preservation and axon degeneration [R]. They are primarily non-steroidal and exhibit a wide range of structural diversity.

The LGD-4033 + RAD-140 + S-23 configuration is intended for scientific research. It is designed to optimize the prospective advantages of these SARMs in terms of improved endurance and muscle strength. Furthermore, this combination may facilitate improved recovery and increased energy levels. The formula utilizes LGD-4033, RAD-140, and S-23’s muscle-building capabilities. Protein-enhancing features also boost these combinations. By targeting AR, this unique SARM combination may improve tissue health and growth. Blend ingredients may have several functions. This may increase muscle gain, strength, and endurance. It may also help lose weight and recover faster.

LGD-4033 + RAD-140 + S23 Formula includes LGD-4033, RAD-140, and S23 in tablet, capsule, & liquid forms:

Tablets: Offered in two variants-25 mg RAD-140, 25 mg LGD-4033, and 25 mg S23, totaling 75 mg per tablet. Available in two options: 20 tablets (1500 mg total) or 40 tablets (3000 mg total).

• Capsules: 25 mg RAD-140, 25mg LGD-4033, and 25 mg S23, totaling 75 mg per capsule. Available in 40 capsules (3000 mg total).
• Liquid: 33.3 mg LGD-4033, 33.3 mg RAD-140, and 33.3 mg S23, totaling 100 mg per ml for a 30 ml bottle (3000 mg total).

What is Ligandrol?

CAS	1165910-22-4
Molar Mass	338.25 g/mol
Chemical Formula	C14H12F6N2O
IUPAC Name	4-[(2R)-2-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Ligrandol may increase lean body mass, making it an appealing muscle growth drug [R]. This oral non-steroidal SARM is developed by Ligand Pharmaceuticals. A Ki value of 1 nM indicates high androgen receptor binding affinity. Animal studies reveal LGD-4033 anabolic effects on muscle. It is anti-resorptive and anabolic. Due to these traits, LGD-4033 became important in bone and muscle health investigations.

How it works

LGD-4033 shows promise in treating muscle atrophy and osteoporosis. The chemical may boost protein synthesis and bone health. LGD-4033 activates androgen receptors. This stimulation may boost muscular strength and hypertrophy [R]. It accomplishes so without having a major impact on other hormonal pathways or producing negative effects associated with androgenic drugs. Unlike steroids, LGD-4033 binds strongly to androgen receptors but acts as a weak agonist in the prostate [R][R]. This reduces the risk of prostate hyperplasia. Its specific androgen receptor interactions cause tissue selectivity. These interactions target muscle and bone without prostate side effects [R]. Its safety and efficacy are being studied to determine its medicinal potential.

Ligandrol may:

• It may potentially promote muscle growth, leading to increased lean mass.[R]R][R][R]
• It may improve bone health [R] [R] [R]
• It shows potential as a treatment for sarcopenia. [R]
• It might enhance sex hormone levels in aged test subjects.[R][R][R]
• May aid in faster recovery from hip fractures [R] [R]
• It helps reduce prostate enlargement. [R]
• It might increase bone density. [R]
• It might have anabolic effects on the bones and muscles. [R]

What is RAD-140?

CAS	1182367-47-0
Molar Mass	393.8 g/mol
Chemical Formula	C20H16ClN5O2
IUPAC Name	2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile

Non-steroidal SARM RAD-140, also known as Vosilasarm or Testolone, is a complete AR agonist in skeletal muscle tissue. It influences muscle development and repair [R][R]. However, RAD-140 also acts as a partial antagonist of ARs in the prostate and breasts. This action blocks AR activation and AR-mediated cellular proliferation [R]. Muscle growth is more affected by RAD-140 than prostate enlargement [R].

The prostate and seminal vesicles receive fewer anabolic advantages from RAD-140 due to potency and efficacy selection. It has promising pharmacokinetics and anabolic potential [R]. RAD-140 has a promising clinical profile. It has successfully completed toxicology studies in both rats and monkeys. Preclinical studies in these animals demonstrated that RAD-140 has anabolic effects on muscle. It shows a reduced impact on prostate growth compared to testosterone [R]. This implies that RAD-140 may provide focused anabolic benefits with fewer adverse effects.

As of now, RAD-140 is being prepared for Phase I clinical trials in patients suffering from severe weight loss due to cancer cachexia. This selective androgen receptor modulator has also been examined for its use in hormone receptor-positive breast cancer combination treatment. [R][R]

How does RAD-140 sarms work?

RAD140 interferes with the ER signaling pathway resulting in reduced estrogen receptor (ER) activity by direct inhibition or breaking down of ER proteins [R]. The precise mechanism behind RAD-140’s tissue-selective effects is not fully understood, but it is believed that its unique recruitment of transcription or coregulator factors, along with its inability to undergo aromatization or 5AR-reduction, plays a significant role [R][R][R].

RAD140 interferes with the estrogen receptor (ER) signaling pathway. This reduces ER activity by directly inhibiting or breaking down ER proteins [R]. The mechanism behind RAD140’s tissue-selective actions is unknown. Its precise recruitment of transcription or coregulator factors may matter. However, its specific recruitment of transcription or coregulator factors may be important. Moreover, RAD140’s inability to 5AR-reduce or aromatize could possibly be a factor in its actions. [R][R][R]

Research shows that RAD140 and its related compound RAD192 exhibit neuroprotective properties in cultured neurons by mimicking the activation of MAPK/ERK signaling, a mechanism known to contribute to androgen-mediated protection in non-neural cells and several important functions in the brain, including neurogenesis, differentiation, synaptic plasticity, memory formation, and cell survival [R][R]

Studies suggest that RAD140 and RAD192 protect cultured neurons. They imitate MAPK/ERK activation. This mechanism helps testosterone protect non-neural cells. It affects various vital brain functions. These include neurogenesis, differentiation, synaptic plasticity, memory formation, and cell survival. [R][R]

RAD140 may:

• It may help in triple-positive breast cancer [R][R]
• It may function as potential neuroprotective therapy for neurodegenerative diseases [R]
• It may improve muscular mass and bone density by stimulating muscle development. [R]

What is S-23?

CAS	1010396-29-8
Molar Mass	416.8 g/mol
Chemical Formula	C18H13ClF4N2O3
IUPAC Name	(2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide

S-23 is an arylpropionamide-based SARM. It has been investigated for possible use as a male hormonal contraceptive in animal models. However, it is not yet accessible for therapeutic usage [R].

This formula’s third SARM may boost muscle mass and bone density. It may treat muscular wasting and osteoporosis. This tissue-selective drug may be effective for anabolic agents. Traditional androgenic steroids may have more negative effects than this method. S-23 was identified as a potent AR agonist with high binding affinity and specificity in vitro [R]. Studies conducted in vivo reveal that the prostate, seminal vesicle, and levator ani muscle weights were considerably higher in castrated rats. [R][R]

How does S-23 work?

S-23, like other SARMs, binds to androgen receptors in the body. This initiates anabolic activity primarily in muscle and bone tissues. It minimizes androgenic effects in other tissues. After binding to the AR, the S-23 moves to the cell nucleus & recruits cofactors and co-regulatory proteins to regulate gene expression [R].

It should be noted that S-23 may have side effects, including testosterone suppression. This could require Post-Research Recovery Protocol to restore natural hormone levels.

S-23 may:

• Assist in fat loss by increasing lean muscle mass and could also serve as a male contraceptive [R].
• It may potentially reduce fat mass [R][R]

FREQUENTLY ASKED QUESTIONS

Where to buy LGD-4033 + RAD-140 + S23 Formula for sale?

PureRawz is one of the top suppliers of potent SARM formulas, such as LGD-4033 + RAD-140 + S23 Formula. As a SARMs enthusiast, you can also buy LGD-4033, RAD-140, and S23 separately at PureRawz. We also have other compounds, such as Jackhammer tablets, YK11, Andarine, Cardarine, and Ostarine. Various formulas tablets, capsules, and liquid forms are also available.

To produce a quality item, we carry the item’s reference materials with every product we sell. Each of our chemicals comes with a third-party lab Certificate of Analysis.

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Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with the appropriate IRB oversight. All preclinical research must be conducted with relevant IACUC following the AWA guidelines.

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