Cardarine (GW-501516)

(36 customer reviews)

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Description

Cardarine (GW-501516) – Product Details

GW-501516, also known as Cardarine, is a PPAR agonist. Cardarine is used in research for its potential to facilitate fat-burning by increasing endurance and stamina.

A study done on the effects of GW-501516 for enhancing running endurance in Kunming mice demonstrated that a 3-week dosing protocol with GW-501516 was able to increase performance related to running of both trained and untrained mice.

Similar to training, GW-501516 showed a potential increase in mitochondrial fatty acid oxidation and enhanced fat metabolism in muscle tissue. This could potentially lead to less demanding cardiovascular work, increasing weekly deficits, and resulting in increased fat loss.

Another study found that when dosed to obese rhesus monkeys, GW-501516 caused a dramatic dose-dependent rise in high-density lipoprotein cholesterol while lowering the levels of low-density lipoprotein cholesterol, fasting triglycerides, and fasting insulin.

Cardarine
CAS Number 317318-70-0
Molar Mass 453.49 g/mol
Chemical Formula C21H18F3NO3S2
IUPAC Name {4-[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid

How Does GW-501516 Work?

Cardarine selectively targets the peroxisome-activated receptor (PPAR) with high affinity and potency, which is why it is termed a PPAR agonist. PPAR agonists are known to enhance fatty acid metabolism, preserving glucose and physical endurance. [R] [R]

Research has shown that this research compound regulates fatty acid oxidation in several tissues, such as the skeletal muscle tissue and adipose tissue. This shows immense promise in the potential ability of Cardarine to cause fat loss and offer additional benefits.

 

Cardarine Research

Multiple animal studies have been carried out on Cardarine. This PPAR Delta receptor agonist has also attracted a few clinical trials. However, the available clinical data isn’t sufficient to claim it is safe for human consumption. More clinical trials are needed to determine its long-term consequences.

 

Cardarine and Cholesterol

GW-501516 (2.5, 5.0, or 10.0 mg) or placebo was given for 12 weeks, to patients (n=268) with high-density lipoprotein (HDL) cholesterol <1.16 mmol/L. Fasting lipids/apolipoproteins (apos), insulin, glucose, and free fatty acid were measured; changes from baseline were calculated and assessed.

GW-501516 demonstrated HDL cholesterol increases up to 16.9% (10 mg) and apoA-I increases up to 6.6%. Reductions were observed in low-density lipoprotein (LDL) cholesterol (-7.3%), triglycerides (-16.9%), apoB (-14.9%), and free fatty acids (-19.4%). [R]

A second smaller exploratory study assessed GW-501516’s impact on lipoprotein particle concentration. Significant reductions in the concentration of very low LDL (-19%), intermediate LDL (-52%), and LDL (-14%) were observed, whereas the number of HDL particles increased by 10%.

 

Cardarine and Fatty Acids

A small study was conducted on mice to assess the impact of PPAR delta agonists on fatty acids. It was found that GW-501516 treatment induced fatty acid oxidation in mouse skeletal muscles.

Aside from that, Cardarine treatment also markedly improved diabetes. This was revealed by the decrease in plasma glucose and blood insulin levels in obese mice. These data suggest that GW-501516 merits further investigation for its potential ability to induce fatty acid oxidation. [R]

 

Cardarine and Running Endurance

A study was carried out to assess the impact of GW-501516 on running endurance in Kunming mice.

It was observed that this research compound enhanced running endurance in both trained and untrained mice. GW-501516 treatment also increased the percentage of slow-twitch muscle fibers. [R]

 

Cardarine and Inflammation

A recent study set out to investigate the effects of GW-501516 as a PPAR delta agonist on inflammation in mice. It was found that GW-501516 treatment reduced atherosclerotic lesions. This data shows that Cardarine merits further investigation as a potential treatment for atherosclerosis. [R]

To further assess its anti-inflammatory activity, one study examined interleukin-6 levels, which we know to be a marker of inflammation. The results obtained showed that GW-501516 might be useful for suppressing specific systemic inflammatory reactions. [R]

 

Cardarine and Metabolism

A study investigated the effects of GW-501516 administration on metabolic disorders in Caucasian men (ages 18 – 15). It was observed that a two-week treatment with GW-501516 ameliorated multiple metabolic abnormalities, including obesity, insulin resistance, and oxidative stress. [R]

Longer randomized trials and research could potentially evaluate its efficacy in improving physical function and health outcomes in select populations.

 

Cardarine FAQs

Is Cardarine A SARM?

Cardarine is not a selective androgen receptor modulator or SARM. SARMs work by binding androgen receptors in specific tissues, whereas GW-501516 specifically targets the peroxisome-activated receptor (PPAR).

 

Is Cardarine Legal?

Cardarine is legal to buy and sell as a research compound. It can be used for laboratory research purposes only.

 

What Is The Half-Life of Cardarine?

Cardarine has a half-life of between 12 and 24 hours.

 

Does GW-501516 Increase Muscle Gene Expression?

Research has shown that Cardarine increases muscle gene expression, especially genes involved in preferential lipid utilization. This highlights its potential ability to enhance the cholesterol profile.

 

Where to Buy GW-501516 Online

Pure Rawz is the best place to buy Cardarine online.

In order to be the best SARMs supplier, we provide reference materials with every product we sell. Each of our SARMS comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.

We offer free international shipping on all orders above $100. You can pay for your purchase through various methods like crypto and credit card. Click on the ‘Reviews’ tab to check out what existing customers have to say about our products and great customer service.

Summary

Cardarine has demonstrated its ability to reduce inflammation, cause fatty acid oxidation, and improve cholesterol profile in animal studies. Long-term and randomized clinical trials are needed to evaluate its safety and efficacy in humans.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).
Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase, based on your own personal circumstances. You should independently research and verify any information that you find on our Website and wish to rely upon.
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ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY not for veterinary or human usage.

COA

COA GW 501516 lot 0089 2023 08 17 PR1 1

36 reviews for Cardarine (GW-501516)

  1. User Avatar: Wesley Riles

    Wesley Riles

    Loving it. The results are quick and real.

  2. Wesley R

    Super efficient for cutting.

  3. Jonathan Manley

    This product delivers 100%! Very impressed.

  4. Fredrick McGuire

    Great costumer support.

  5. Mason Robinson

    Got the tabs and I must say they are a super convenient way to see great results.

  6. Mitchell Nel

    Getting the summer body back!

  7. Keith Yarrow

    100% satisfied.

  8. Marc Finch

    Real results – very happy.

  9. Kingsley Evers

    Highly recommendable.

  10. Jason F

    One of the best quality cardarines

  11. Ayrton Galagher

    The shreds are incredible!

  12. Mike Kastins

    Really upped my endurance. Fantastic product.

  13. Adrian R

    Quick results that you can most definitely notice.

  14. Gordon Westerman

    Outstanding quality, real results.

  15. Chris E

    Fast fat loss and endurance gain

  16. Eric Wilson

    Better heart health. Doctor is amazed.

  17. Innes White

    Burning lots of calories quickly.

  18. jschristmas

    Really good product to increase endurance and help lose fat. I can tell a difference when I take this in my overall performance and stamina. A must for any cutting cycle or event prep.

  19. Julian Nixon

    Noticeable improvement in my cardio at the gym when I use this.

  20. Martin Scott

    This stuff is amazing, helped me get back in shape fast.

  21. Daniel Brown (verified owner)

    Love this product! I can not believe the over all good feeling I get when taking it. And no matter how hard I work out I don’t get sore~

  22. Joe K

    Great results!

  23. Ben Whitehead

    Excellent product , great results in a short time

  24. Charlie Edwards

    I am unstoppable thanks to your quality product! I recommended your website to some of my friends

  25. Matthew J

    Very happy with the quality of this product! Seeing great results so far.

  26. Jestoni Miller

    Awesome! I’ll keep buying this great product because it’s so great.

  27. Nate Wilson

    Very productive for cutting. I have been searching for this outcome!

  28. Zak Robinson

    Awesome! Excellent supplement for increasing endurance and aiding in fat loss.

  29. Morris Soe (verified owner)

  30. Anonymous (verified owner)

  31. Mark (verified owner)

    Long delivery but excellent packaging. Been on GW for about a week now and the endurance is 100% noticeable. Not 75% more but like 50% more. I’m on Tren and nandrolone so I have no endurance but I’m now able to run a couple miles at full speed without gassing. Lost 10lbs and feel healthier 4/5 only because delay on shipping and no tracking but great product

  32. Carl (verified owner)

  33. Reginald Tubman (verified owner)

  34. Madheatfan3

    Great stuff fat loss and increased cardio in a bottle. Able to hit the weights longer for sure

  35. Anthony (verified owner)

  36. jackhannedy

    Great results! I will be back for more.

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