MIF-1

Description

Overview

MIF-1 (Melanocyte-Stimulating Hormone Release-Inhibiting Factor-1) is a synthetic tripeptide. It is composed of the amino acid sequence Pro-Leu-Gly-NH2. It belongs to a group of endogenous neuropeptides originally identified in brain tissue. It is investigated in biochemical and neurochemical research models.

MIF-1 is structurally related to peptides involved in neuropeptide signaling. It has been examined in laboratory studies focused on:

• peptide transport

• receptor interaction, and

• intracellular signaling mechanisms

Research involving MIF-1 frequently explores its interactions with multiple molecular pathways within experimental systems.

The compound is supplied strictly as a research material intended for controlled laboratory investigation.

MIF-1

Property	Description
Compound Name	MIF-1
Peptide Sequence	Pro-Leu-Gly-NH2
Peptide Class	Synthetic tripeptide
Synonyms	Melanostatin, Pro-Leu-Gly-NH2
Molecular Type	Neuropeptide fragment
Research Category	Peptide signaling research compound

Mechanism of Action

Neuropeptide Signaling Interaction

MIF-1 has been investigated in laboratory experiments for its interaction with multiple intracellular signaling pathways. These are the ones associated with peptide-mediated molecular communication. Experimental data indicate that the peptide may influence cellular signaling markers such as pERK and STAT3 phosphorylation pathways in neuronal cell models.

Receptor Binding Investigations

Studies examining MIF-1 and related peptides have reported that these compounds may exhibit distinct receptor-binding characteristics compared with structurally similar peptides found in neural tissues. Analytical work on related peptides in the MIF-1 family has identified unique receptor interaction profiles in brain tissue preparations.

Peptide Transport and Molecular Stability

Due to its small peptide structure, MIF-1 is commonly examined in research investigating peptide transport mechanisms and molecular stability within biological systems. Its simple tripeptide composition allows researchers to analyze structure-function relationships in short peptide signaling molecules.

Research Applications

In controlled laboratory environments, MIF-1 may be utilized for investigations involving:

• peptide signaling pathway analysis
• receptor-binding characterization studies
• neuropeptide transport and distribution research
• structure-activity relationship studies involving short peptides
• analytical characterization of tripeptide signaling molecules

All applications are restricted strictly to analytical and experimental research environments.

Why Choose Purerawz?

Buy MIF-1 for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials intended strictly for research purposes. Each compound is supplied with an independent third-party Certificate of Analysis verifying identity, purity, and concentration.

Note: MIF-1 is an investigational compound currently undergoing scientific evaluation and has not been established as safe or effective for any therapeutic application.

Disclaimer

This information is for educational purposes only and does not constitute medical advice.

THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the Institutional Animal Care and Use Committee (IACUC) in accordance with the guidelines of the Animal Welfare Act (AWA).

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ATTENTION: All products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use.

References

Khan, R. S., Yu, C., Kastin, A. J., et al. Brain activation by peptide Pro-Leu-Gly-NH₂ (MIF-1). International Journal of Peptides. PubMed: https://pubmed.ncbi.nlm.nih.gov/20721355/

Hackler, L., Kastin, A. J., & Zadina, J. E. Isolation of a novel peptide with a unique binding profile from human brain cortex: Tyr-K-MIF-1. Peptides. PubMed: https://pubmed.ncbi.nlm.nih.gov/7991457/