PE-22-28

Description

Overview of PE-22-28

PE-22-28 is a synthetic peptide derivative structurally related to spadin, a fragment associated with the sortilin pathway. It is characterized in biochemical research as a peptide investigated for its interaction with the TREK-1 (TWIK-related potassium channel 1) ion channel. 

Current investigations primarily examine its interaction with ion channel signaling pathways and its influence on cellular electrophysiology under controlled laboratory conditions.

Chemical and Molecular Properties 

PE-22-28
PubChem CID	172871876
Molecular Formula	C35H59N11O11
Molecular Weight	833.9 g/mol
Synonyms	PE 22-28 (acetate)
IUPAC	acetic acid;(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[(2-aminoacetyl)amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
CAS	1801959-12-5
Labeling	Research-use peptide
Chemical Structure Depiction
Purity	Purity ≥95% (verified by HPLC or equivalent analytical method)
Classification	Research Use Only (RUO)
Storage Temperature	-20°C
Solubility	Soluble in aqueous buffers under controlled pH
Safety	For controlled laboratory handling only

Proposed Working Mechanism of PE-22-28

PE-22-28 is being investigated for its interaction with TREK-1 potassium channels, which are part of the two-pore domain potassium (K2P) channel family. These channels contribute to the regulation of membrane potential and ion flux across cellular membranes. In controlled experimental systems, PE-22-28 has been reported to associate with TREK-1-related sites, with potential effects on potassium ion conductance and membrane polarization.

This interaction is being studied for its potential to modulate downstream signaling pathways linked to ion channel activity. In particular, changes in ion permeability and channel gating behavior are being studied for their potential to influence intracellular signaling cascades in controlled experimental systems. 

Ongoing biochemical investigations also explore how TREK-1 modulation contributes to broader signaling network activity. These investigations include pathways related to ion homeostasis, membrane stability, and electrophysiological regulation under controlled experimental conditions. 

Why Choose Purerawz for PE-22-28 Peptide?

Buy PE-22-28 peptide for laboratory research use from our online shop. At Purerawz, we provide high-quality reference materials. Each research compound comes with a Certificate of Analysis for verification of purity and concentration.

Note:

PE-22-28 peptide is an investigational compound. It is not established as safe or effective for any therapeutic use.

Disclaimer

This information is for educational purposes only and not medical advice. Products are for research use only. Research must follow IRB or IACUC guidelines. Verify information independently before purchasing. By ordering, you agree to our Terms and Conditions. If you are not 100% satisfied with the product you received, please contact us at support@purerawz.co

ATTENTION: All our products are for LABORATORY AND RESEARCH PURPOSES ONLY, not for veterinary or human use

Reference Links

• National Center for Biotechnology Information (2026). PubChem Compound Summary for CID 172871876, PE 22-28 (acetate). Retrieved April 22, 2026 from https://pubchem.ncbi.nlm.nih.gov/compound/PE-22-28-_acetate. 
• Djillani, A., Pietri, M., Moreno, S., Heurteaux, C., Mazella, J., & Borsotto, M. (2017). Shortened Spadin analogs display better TREK-1 inhibition, in vivo stability and antidepressant activity. Frontiers in Pharmacology, 8, 643. https://doi.org/10.3389/fphar.2017.00643