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Tianeptine is a unique yet controversial compound that has garnered the intention of researchers worldwide. Initially developed in the 1980s as a treatment for depression, Tianeptine is currently classified as an atypical tricyclic antidepressant. Research shows it works by modifying the glutamatergic system by controlling AMPA and NMDA receptors. This unique mode of action allows Tianeptine to improve serotonin reuptake in specific brain areas. This is in contrast to conventional antidepressants that raise serotonin levels.
Although it is not federally classified as a controlled substance, it has been restricted or outright banned in several states in the U.S.
| State | Detail |
|---|---|
| Michigan | Michigan became the first U.S state to ban Tianeptine Sodium. It has been classified as a schedule II controlled substance. |
| Alabama | On March 15, 2021, Alabama classified tianeptine as a Schedule II controlled substance and later reclassified it to Schedule I on November 14, 2021, making its sale and possession illegal without a prescription. |
| Tennessee | Effective July 1, 2022, Tennessee outlawed tianeptine, classifying it as a Schedule II controlled substance, which includes tianeptine and its derivatives. |
| Ohio | On December 22, 2022, Ohio classified tianeptine as a Schedule I controlled substance. |
| Kentucky | On March 23, 2023, Kentucky reclassified tianeptine-containing products as Schedule I controlled substances by emergency regulation. |
| Florida | On September 20, 2023, Florida's Attorney General issued an emergency rule classifying tianeptine as a Schedule I controlled substance. |
| Georgia | Classified as a Schedule I controlled substance, the sale and possession of all forms of Tianeptine are prohibited under law. |
| Indiana | Classified as a Schedule I controlled substance, the sale and possession of all forms of Tianeptine are prohibited under law. |
| Mississippi | As of early 2023, a bill that will outlaw tianeptine has been enacted by the state legislature and is awaiting the governor's signature. |
| South Carolina | In January 2024, South Carolina House Bill 4870 was introduced, proposing to add tianeptine to Schedule I of the state's controlled substances list. The bill was referred to the Judiciary Committee but has not progressed further and is currently considered inactive. |
| Delaware | In December 2024, Delaware House Bill 21 was introduced, aiming to classify tianeptine as a Schedule I controlled substance. This would make it illegal to sell, possess, or distribute tianeptine in the state. The bill is currently under review by the House Health & Human Development Committee. |
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