Description

DNSP-11 – Product Information

DNSP-11 (Dopamine Neuron Stimulating Peptide-11) is a synthetic peptide designed to mimic a portion of proBDNF (pro-brain-derived neurotrophic factor). This peptide has shown potential in promoting the survival and function of dopaminergic neurons, which are crucial for motor control and are notably affected in neurodegenerative diseases like Parkinson’s disease.

• In the context of research, it is advisable to opt for bacteriostatic water when reconstituting substances rather than sterile water.

DNSP-11
CAS Number	616204-22-9
Molar Mass	1180.27
Chemical Formula	C50H81N15O18
IUPAC Name	N/A

What is DNSP-11?

Dopamine Neuron Stimulating Peptide-11 (DNSP-11) is derived from the prosequence of the Glial Cell Line-Derived Neurotrophic Factor (GDNF), DNSP-11 holds immense promise as a research chemical with potent neurotrophic actions.

Neurotrophic factors like GDNF are naturally produced in the body as proproteins, which undergo proteolytic processing to yield various functional peptides. In the case of GDNF, the examination of its prosequence has revealed the presence of internal dibasic endopeptidase sites. Upon proteolytic cleavage, an 11-mer amidated peptide named Dopamine Neuron neuron-stimulating peptide-11 (DNSP-11) is generated. Remarkably, a rat homolog of DNSP-11 called brain excitatory peptide (BEP) has already demonstrated its functionality as a neuropeptide, exhibiting an increase in synaptic excitability.

What makes DNSP-11 particularly exciting is its ability to exhibit potent neurotrophic actions similar to mature GDNF. This characteristic positions DNSP-11 as a promising candidate for potential therapeutic applications in Parkinson’s disease (PD) treatment. However, intriguingly, DNSP-11 appears to signal through pathways that do not directly involve the GFRa1 receptor, suggesting the existence of novel mechanisms underlying its neurotrophic effects.

While DNSP-11 is currently intended for research purposes only and should not be used for human consumption, its immense potential as a research chemical cannot be overstated. As scientists continue to delve deeper into the properties and mechanisms of DNSP-11, the prospects for groundbreaking advancements in the understanding and treatment of neurological conditions are ever-increasing.[R]

DNSP-11 Research

Numerous animal and human studies have been conducted on the potential application of DNSP-11. Below are some of the relevant benefits findings:

DNSP-11 and Parkinson’s disease

A study demonstrates Dopamine Neuron Stimulating Peptide 11 (DNSP-11) for the protection of dopaminergic neurons in a rat model of Parkinson’s disease (PD).In the study, researchers used young adult Fischer 344 rats and gave them DNSP-11 through their noses. This led to a dose-dependent increase in dopamine turnover in a specific brain area called the striatum. The increase was measured by looking at the ratio of DOPAC to dopamine. In comparison, the rats in the control group, who received only a liquid without DNSP-11, did not show the same increase.

The researchers also studied the effects of DNSP-11 in rats with a condition similar to Parkinson’s disease. They created this condition by causing a specific brain area called the substantia nigra to have damage similar to what is seen in Parkinson’s disease. When these rats were treated with DNSP-11 through their noses, they had more dopaminergic neurons in the substantia nigra that were positive for a substance called tyrosine hydroxylase (TH). Additionally, there was an increase in TH+ fibers in the striatum. This suggests that DNSP-11 may have a protective effect on dopaminergic neurons, which are important for normal brain function. [R]

Further research and investigations are needed to fully understand the precise mechanisms and long-term effects of dopamine neurons’ function in treating PD. However, the non-invasive nature of intranasal administration and the observed neuroprotective and behavioral improvements make DNSP-11 a promising candidate for future therapeutic development in PD.

DNSP-11 and Rotational Behavior in PD

In animal studies, a single injection of DNSP-11 into the substantia nigra of normal adult rats resulted in its rapid uptake by neurons. This uptake led to increased resting levels of dopamine and its metabolites for an extended period of up to 28 days. Notably, DNSP-11 exhibited a significant improvement in apomorphine-induced rotational behavior, a common behavioral measure in PD research. It also increased dopamine and dopamine metabolite tissue levels in the substantia nigra, highlighting its potential as a therapeutic option for PD.[R]

However, it’s important to note that while these animal studies have shown promising results, further research is needed to determine the effect of snap recipients of DNSP-11 on the central dopamine system and dopamine neuron function.

DNSP-11 and Dopamine Release

Recent studies have demonstrated that DNSP-11 and related peptides derived from the GDNF proregion can affect the nervous system. Using high-speed chronoamperometry, researchers investigated the effects of DNSP-11 on dopamine release in the striatum at different time points post-treatment. They found an elevation in dopamine release after two weeks of therapy, suggesting a localized effect of DNSP-11 on dopamine release patterns. However, additional research is needed to gain a comprehensive understanding of the impact of DNSP-11 on dopamine [R] More study is necessary in order to understand the effect that DNSP-11 dopamine has.

Summary of DNSP-11

DNSP-11, or Dopamine Neuron neuron-stimulating peptide-11, is a research chemical derived from the prosequence of the Glial Cell Line-Derived Neurotrophic Factor (GDNF). It holds promise as a potent neurotrophic agent with potential therapeutic applications in Parkinson’s disease (PD) treatment. DNSP-11 exhibits neurotrophic actions similar to mature GDNF, but it appears to signal through novel mechanisms that do not directly involve the GFRa1 receptor.

Research conducted on DNSP-11 has shown promising results in relation to Parkinson’s disease. Studies on rat models have demonstrated that DNSP-11 can protect dopaminergic neurons and increase dopamine turnover in the striatum, a specific brain area. In rats with conditions similar to Parkinson’s disease, DNSP-11 treatment led to an increase in dopaminergic neurons and TH+ fibers, suggesting a potential neuroprotective effect.

Additionally, DNSP-11 has been found to improve apomorphine-induced rotational behavior, a common measure in PD research. It increases resting levels of dopamine and its metabolites in the substantia nigra for an extended period. These findings indicate its potential as a therapeutic option for PD. However, further research is necessary to determine its efficacy and safety in humans. Moreover, DNSP-11 has been shown to affect dopamine release in the striatum, with an elevation observed after two weeks of treatment. However, more research is required to fully understand the impact of DNSP-11 on dopamine release patterns.

While DNSP-11 is currently intended for research purposes only and should not be used for human consumption, its potential as a research chemical holds promise for advancements in the understanding and treatment of neurological conditions. Further investigations are needed to fully comprehend the precise mechanisms, long-term effects, and safety profile of DNSP-11.

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