MOTS-c – Product Information
MOTS-c is a mitochondrial-derived peptide naturally produced in the body. Preclinical research has shown that it has the potential to promote metabolic homeostasis, enhance exercise capacity, and improve osteoporosis. The peptide has also been shown to potentially boost insulin levels.
In cell-based studies, MOTS-C was reported to increase the intracellular levels of NAD+, a coenzyme that influences DNA repair, immune cell function, and stress response. Aside from this, MOTS-c reduces the activity of myostatin, the enzyme that inhibits muscle growth.
Pure Rawz sells MOTS-c for laboratory and research purposes only.
|Molar Mass||2174.7 g/mol|
What is MOTS-c?
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome. It is expressed in various tissues, including skeletal muscle, as well as in circulation. Research shows that while plasma MOTS-c levels decline with age, muscle MOTS-C levels increase. [R]
Unlike other endogenous peptides, such as DSIP, MOTS-c cannot penetrate the blood-brain barrier. Still, it has been shown to reduce inflammation-based memory problems in preclinical studies. In mice, MOTS-C was found to protect against AB42 and LPS (inflammation). [R]
This peptide has been shown to regulate nuclear gene expression, fat metabolism, and glucose uptake. Research has also found that MOTS-c peptide enhances insulin sensitivity, promotes the differentiation of bone marrow stem cells, and counters diet-induced insulin resistance.
How does MOTS-c Work?
Following are the proven effects of MOTS-c:
Reduces myostatin levels
Preclinical studies show that plasma MOTS-c levels are inversely correlated with circulating myostatin levels. Moreover, MOTS c treatment has been found to decrease myostatin levels in mice. These effects show that this peptide is a novel myostatin inhibitor. [R]
Activates AMP-activated kinase
AMP-activated kinase (AMPK) is a cell’s energy sensor. AMPK stimulates pathways that increase energy production (glucose transport, fatty acid oxidation). It also switches off pathways that consume energy (lipogenesis, protein synthesis). [R][R]
Suppresses folate cycle
The folate cycle is crucial to proper cellular function and metabolism. It is also responsible for the dysfunction of the natural killer cell, which is a type of immune cell (i.e., a type of white blood cell) that kills tumor cells or cells infected with a virus. [R][R]
Increases AICAR levels
AICAR (5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside) is a substance produced naturally by the body. AICAR has been shown to augment insulin action, up-regulate mitochondrial enzymes in skeletal muscles, and decrease the intra-abdominal fat content. [R][R]
Following is a summary of the existing research on MOTS-c. The information given in this section is for educational purposes only. It doesn’t constitute medical advice. Speak to a qualified medical health provider to know more about MOTS-c peptide.
MOTS-c and Insulin Sensitivity
Insulin sensitivity refers to how sensitive the body is to the effects of insulin. An improved/high insulin sensitivity reduces blood sugar and your risk of developing diabetes. [R]
In a preclinical study, mice treated with MOTS-c injections for 7 days had enhanced glucose clearance indicative of improved insulin sensitivity. Results from the study show that MOTS-c improved whole-body insulin sensitivity independent of changes in body weight. [R]
MOTS-c and Obesity
A 2017 study in China measured MOTS-c levels in 40 obese children and 57 healthy males. The obese group was found to have significantly decreased MOTS-c levels. [R]
Furthermore, MOTS-c levels were negatively correlated with body mass index (BMI), waist circumference, and waist-to-hip ratio. These results indicated that MOTS-c levels were inversely proportional to obesity and insulin resistance parameters. [R]
MOTS-c and Osteoporosis
Osteoporosis is a skeletal muscle disease that is characterized by bone mass decrease and bone structural damage. In the US, over 10 million people aged 50 years and older have osteoporosis. [R]
A cell-based study has demonstrated that MOTS-c improves osteoporosis by promoting the synthesis of type I collagen in osteoblasts. In another study, this peptide was shown to suppress ovariectomy-induced bone loss via AMPK activation. [R][R]
MOTS-c and Longevity
With an average life expectancy of 85.03 years for both sexes, Japan has the 2nd highest life expectancy of all the countries in the world. [R]
MOTS-c has been suggested to be among the putative biological mechanisms explaining the high longevity of Japanese people. The polymorphism located in the MOTS-c encoding mtDNA, which is specific for the Northeast Asian population, is hypothesized to exert this effect. [R]
MOTS-c and Heart Health
A clinical study on 40 patients undergoing angiography reported levels of circulating MOTS-c in patients with endothelial cell dysfunction. Endothelial cells regulate blood pressure, plaque formation, and blood clotting. The study suggests the implication of MOTS-c in cardiovascular disease. [R]
A preclinical study examined the effects of MOTS-c on cardiac function. Administration of exogenous MOTS-c was found to improve the mechanical efficiency of the myocardium. It also strengthened the systolic function of the heart. [R]
MOTS-c and Muscle Atrophy
In a preclinical study, MOTS-c inhibited muscle atrophy signaling by reducing myostatin. Myostatin is an enzyme that prevents muscle growth to facilitate easy muscle movement. These results suggest that MOTS-c could be a potential therapy for insulin-therapy-induced skeletal muscle atrophy. [R]
MOTS-c and Fatty Acids
According to a mice study, MOTS-c improves insulin sensitivity and increases beta-oxidation to prevent fat accumulation through three pathways. [R]
Where to Buy MOTS-c Online?
PureRawz is the best place to buy the highest-quality MOTS-c online.
In order to be the best supplier of research chemicals, we provide reference materials with every product we sell. All of our products come with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.
We offer free international shipping on all orders above $100. You can pay for your purchase through various methods, including PayPal and Bitcoin. We sell liquid, powder, and capsule high-quality TUDA formulations. All the formulations are equally high quality.
MOTS-c is an endogenously produced peptide that regulates mitochondrial communication. It also plays a potentially significant role in cardiac cells, boosts insulin levels, and inhibits myostatin levels. Pure Rawz doesn’t sell mitochondrial-derived peptides for human consumption.