5-HTP (5-Hydroxytryptophan)

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5-HTP (5-Hydroxytryptophan) – Product Information

  • 5-HTP Liquid is offered as 67mg per ml for 30ml, totaling 2000mg.

5-Hydroxytryptophan (5-HTP) is an amino acid precursor that helps serotonin form. 5-HTP has been used as an oral supplement alternative to boost serotonin in laboratory settings.

Commercially produced 5-HTP is typically available in natural color variation and is egg-free.

Dietary supplements for 5-HTP are only approved for laboratory purposes since they may lead to certain side effects. This research chemical still requires significant clinical trials before being approved as safe for human usage.

The 5-HTP sold by PureRawz is for laboratory research use only and is not for human consumption.

CAS Number 4350-09-8
Molar Mass 220,23 g/mol
Chemical Formula C11H12N2O3
IUPAC Name 2-amino-3- (5-hydroxy-1H-indol-3-yl) propanoic acid


What is 5-HTP?

5-HTP (5-hydroxytryptophan) is a chemical produced by the body from the amino acid l tryptophan (an essential amino acid you get from food).

After tryptophan is converted into 5-HTP, the chemical is transformed into serotonin (a neurotransmitter that relays signals between brain cells). 5-HTP aids in increasing levels of serotonin in the brain, thus influencing the central nervous system.

Because serotonin promotes a positive mood and behavior, 5-HTP may treat insomnia, mood, anxiety, appetite, and pain relief.

5-HTP, available online, is a research chemical from a particular African plant. It is used as a dietary supplement in laboratory-controlled research trials. For this reason, the Food and Drug Administration does not recommend 5-HTP for human consumption.

Potential Applications of 5-HTP

5-Hydroxytryptophan (5-HTP) refers to an amino acid that occurs naturally.

5-HTP is potentially used by the body to produce serotonin, a chemical messenger that sends signals between nerve cells.

Depression, anxiety, sleep disorders, weight gain, and other health issues are linked to low serotonin levels.

As a result, increasing serotonin production may have various advantages concerning human medical conditions. According to clinical studies, the following are some potential applications of 5-HTP.

5-HTP and Weight Loss

5-HTP may increase feelings of fullness, causing one’s appetite to decrease, resulting in weight loss. [R][R]

Weight loss can increase the production of hunger hormones. These feelings of constant hunger can make long-term weight loss unsustainable.

A 5-HTP dietary supplement may suppress appetite and help you lose weight by counteracting these hunger-inducing hormones. [R]

Interestingly, 5-HTP primarily inhibited carbohydrate intake, which was associated with better blood sugar control. [R] Furthermore, animal studies have shown that 5-HTP may reduce overeating caused by stress or depression. [R]

5-HTP and Joint Pain

A recent study demonstrated 5-HTP’s potential to help people experiencing rheumatoid arthritis (RA), a medical condition related to joint pains. [R]

The researchers induced an autoimmune reaction in mouse cells similar to RA. These cells were then treated with 5-HTP.

When these cells were given 5-HTP, they produced fewer inflammatory immune cells linked to the damage seen in rheumatoid arthritis. These cells also produce more serotonin and other hormones to relieve pain.

5-HTP and Depression

According to some laboratory studies, using 5-HTP for depression may help improve depressive symptoms leading to a positive mood. [R] [R]

Overall, clinical trials published to date suggest that 5-HTP may be effective in treating depression symptoms alone and in combination with prescription antidepressants.

A related study comparing the effectiveness of slow-release 5-HTP versus immediate-release 5-HTP in mice discovered that the slow-release version was more effective. [R]

It is noteworthy that many reviews conclude that there is still a need for more high-quality research before 5-HTP dietary supplements can be recommended as a treatment for depression. [R]

Indeed, the evidence for 5-HTP and depression suggests that people taking medications, especially antidepressants, should avoid taking 5-HTP.

Serotonin syndrome, a potentially fatal condition characterized by mental changes, hot flashes, rapidly fluctuating blood pressure and heart rate, and possibly coma, may result from such medications interacting with 5-HTP. [R]

5-HTP and Migraine

Low serotonin levels are commonly found in people suffering from depression. Still, migraineurs and people suffering from chronic headache disorders can also have low serotonin levels during and between attacks.

It is unclear why migraines and serotonin are linked. The most widely held belief is that a lack of serotonin makes a person hypersensitive to pain. [R]

A 2017 rat study found that 5-HTP supplementation helped prevent estrogen-related brain changes associated with migraine with aura. This suggests that 5-HTP may work by lessening the effects of migraine triggers. [R]

5-HTP and Sleep

Serotonin is produced by 5-HTP, which can be converted into the hormone melatonin.

It is well known that melatonin is essential for sleep regulation. [R] Its levels increase during nighttime to induce restful sleep.

As a result, 5-HTP may promote sound sleep, addressing insomnia by increasing melatonin production.

One study found that combining 5-HTP and gamma-aminobutyric acid (GABA) reduced the time it took to fall asleep, increased sleep duration, and improved sleep quality. [R]

GABA is a chemical messenger that helps people relax. It is possible that combining it with 5-HTP leads to a synergistic effect.

Several animal and insect studies indicate that 5-HTP improves sleep quality and that the effect is enhanced when combined with GABA. [R] [R] These also suggest that 5-HTP could be taken on an empty stomach before going to sleep.

While the above results are promising, the lack of human-based studies makes it difficult to recommend 5-HTP supplements for improving sleep quality, especially when used alone. For this reason, the Food and Drug Administration does not allow the human consumption of 5-HTP or use it as a treatment for any medical condition.

5-HTP and Fibromyalgia

Based on research done on 5-HTP, this includes a double-blind study of certain patients, the amino acid under consideration may improve symptoms of fibromyalgia, including pain, anxiety, morning stiffness, and fatigue. [R] [R] [R] [R]

Many people with fibromyalgia have low serotonin levels, and doctors frequently prescribe certain medications, especially antidepressants. 5-HTP, like antidepressants, increases serotonin levels in the brain.

There is currently no known cause of fibromyalgia, but low serotonin levels have been linked to the condition. As a result, researchers believe that increasing serotonin levels with 5-HTP supplements may benefit people with fibromyalgia.

How does 5-HTP Work?

5-HTP is a chemical byproduct of the amino acid L-tryptophan, a protein building block. It is commercially produced from Griffonia simplicifolia extract, an African plant.

5-HTP works in the brain and central nervous system by offering neurotransmitter support. This is achieved by increasing serotonin production.

Serotonin can influence sleep, appetite, temperature, sexual behavior, and pain sensation.

Frequently Asked Questions

What is Griffonia simplicifolia?

Griffonia simplicifolia is a plant that grows in western Africa. Because the seeds contain a chemical called 5-hydroxytryptophan, they are used as medicine (5-HTP).

How does 5-HTP affect the central nervous system?

5-HTP triggers serotonin production in the brain and central nervous system.

5-HTP is used to treat conditions where serotonin is thought to play a role because it raises serotonin levels.

These include depression, anxiety, and a variety of other conditions, but most of these applications have little scientific evidence to back them up.

What foods contain 5-HTP?

Aside from being a Griffonia simplicifolia extract, 5-HTP is present in certain foods we consume. These would be the following:

  • Turkey
  • Chicken
  • Milk
  • Potatoes
  • Pumpkin
  • Sunflower seeds
  • Turnip

Where can you buy 5-HTP online?

PureRawz is an online site that is the best place to buy 5-HTP.

To be the best research chemicals supplier, we provide reference materials with every product we sell. Each product comes with an independent, third-party-issued Certificate of Analysis for identification, purity, and concentration.


This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY.

All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB).

All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

Our content is intended to be used and must be used for informational purposes only. It is very important to do your own analysis and research from Trusted Sources before making any purchase based on your own personal circumstances.

You should independently research and verify any information that you find on our Website and wish to rely upon.

By completing and paying for your order, you agree to our Terms and Conditions. Customer satisfaction is our number one priority, if you are not 100% satisfied with the product you received, please contact us at

10 reviews for 5-HTP (5-Hydroxytryptophan)

  1. Ashly J

    Very happy with this product. It has really amazing results.

  2. Stevey Randal

    Happy customer. Happy life

  3. Johnny Long

    Sort of expected this not to work but it really did. If you feel miserable all the time, 5-HTP just might turn things around for you. It also fixed my sleeping schedule. For the first time in my life I go to sleep at a normal hour because I’m finally able to without tossing and turning for hours.

  4. Jacob

    I am very happy with the product and the quality is excellent. Lifted my depression impressively.

  5. Anonymous

    I will buy again for sure.

  6. Nathan Soole

    5-HTP is very affordable and will fit into my budget. I will be ordering again soon!

  7. George Diaz

    This supplement is helping my mood. It calms my body and mind and also makes me more confident!

  8. Stephanie

    I have been feeling so much better since I started this, my overall mood has improved drastically.

  9. Ada Pruitt

    My moods have been much more stable.

  10. Markus Trantow

    I really enjoyed using this. It improves your disposition, relieves tension, reduces anxiety, and increases your mental proactivity.

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