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Baicalin – Product Information

Baicalin is a natural compound classified as a flavonoid. It is found in various plant species, particularly in the roots of Scutellaria baicalensis, commonly known as Chinese skullcap. Baicalin is recognized for its potential antioxidant and anti-inflammatory properties. It has been studied for its potential role in various health conditions, although its applications are primarily in preclinical and experimental research.

CAS Number 21967-41-9
Molar Mass 446.364 g/mol
Chemical Formula C21H18O11
IUPAC Name 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

What is Baicalin?

Baicalin, derived from the skullcap root of the Scutellaria baicalensis Georgi plant, also known as Huang-Qin in traditional Chinese medicine, is a remarkable natural compound with a rich history of potential medicinal use. It’s been valued for its diverse range of potential health benefits. This flavonoid has gained attention for its potential therapeutic properties in various health conditions. Baicalin has been extensively studied for its ability to combat viruses, protect cells from oxidative damage, inhibit the growth of tumors, prevent cell death, reduce inflammation, and promote cardiovascular health, among other effects.

Inflammation is a critical defense mechanism the body uses to heal from injuries or infections. However, when the immune system goes awry, it can lead to various health problems, including neurological disorders like Alzheimer’s disease and depression. Baicalin has shown promise in modulating the immune response by suppressing inflammatory pathways and reducing the production of harmful substances that contribute to inflammation. This review explores the exciting potential of baicalin in addressing inflammation and immune-related issues in cerebrovascular and neurological disorders, shedding light on its role in promoting better nervous system health.

Please note that baicalin is primarily intended for research purposes, and this article does not endorse its use for direct human consumption. Instead, it highlights the compound’s potential therapeutic applications and the need for further scientific investigation. [R]

How It Works

Baicalein may exhibit anti-inflammatory and anti-cancer properties in various types of cancer. It is particularly effective against prostate cancer, where it inhibits the overexpression of 12-lipoxygenase (12-LOX), a regulator of tumor growth. In prostate cancer cells, baicalein suppresses cell proliferation, causes cell cycle arrest, and promotes apoptosis. This is achieved by regulating cell cycle-related proteins and activating caspase-3 and caspase-7. In animal models, baicalein reduces tumor volume, showing potential as an anti-cancer agent. Additionally, baicalein demonstrates cytotoxicity in human lung non-small cell carcinoma cells by inducing cell cycle arrest and apoptosis through the inhibition of 12-LOX enzyme expression.

Baicalein also shows promise in addressing myocardial depression associated with sepsis. It counters the effects of inflammatory mediators like TNF-α and iNOS, improving cardiovascular function and survival rates in animal models. In atherosclerosis, a cardiovascular inflammatory disorder characterized by plaque buildup in arteries, baicalein exhibits anti-inflammatory properties by suppressing NF-κB activation and cellular adhesion molecules. It helps maintain the integrity of the endothelial barrier, reducing inflammation and promoting cardiovascular health.

These findings highlight baicalein’s active ingredient that gives versatile anti-inflammatory properties, making it a promising candidate for a range of inflammatory and autoimmune disorders. However, further research and clinical studies are needed to confirm its effectiveness in human subjects.[R]

Baicalin Research

Numerous studies have been conducted on the potential application of Baicali. Below are some of the relevant findings on mushroom products:

Baicalin on Depression and Anxiety

Baicalin (BA) shows promise in alleviating depressive-like behaviors induced by chronic stress. It achieves this by addressing several key factors in depression. Chronic stress can trigger inflammation and apoptosis, leading to neuron loss. BA may act as an antidepressant by inhibiting inflammation, preventing cell death, and protecting neurons.

In a study involving rats with stress-induced depression, BA administration improved mood-related behaviors and boosted the levels of important brain proteins like doublecortin (DCX), Neuron-specific enolase (NSE), and Brain-derived neurotrophic factor (BDNF) in the hippocampus.[R]

Baicalein, might have a calming effect similar to anxiety-relief medications. In a test using mice, both baicalein and baicalin made the mice more comfortable with mild shocks, kind of like how anxiety medications work( 5-HT1A and benzodiazepine site receptors). These effects are like those of medicines that target specific parts of the brain. It’s important to note that these calming effects could be stopped by one type of medicine, but not by another. This suggests that baicalein and baicalin might work by affecting a certain part of the brain called GABAA receptors, which are linked to relaxation. However, more research is needed to fully understand how these compounds work and if they could be recommended by healthcare professionals. [R]

Baicalin (Skullcap Extract) on cerebrovascular and neurological disorders.

Baicalin has emerged as a promising solution for cerebrovascular and neurological disorders. In numerous studies, it has demonstrated its ability to combat inflammation and regulate the immune system. Baicalin achieves this by targeting various pathways and molecules involved in inflammation, leading to reduced production of inflammatory substances. This, in turn, supports the protection of brain cells and their function in neurological diseases. Through advanced network pharmacology tools, researchers have identified key targets responsible for baicalin’s anti-inflammatory effects. These findings pave the way for potential clinical applications of baicalin in treating cerebrovascular and neurological disorders, offering hope for improved therapeutic approaches.[R]

Baicalin and Skin Health

Studies found that baicalin-loaded tiny bubbles (called nanovesicles) have strong anti-inflammatory effects, no matter how much is administered. These nanovesicles were really good at reducing skin damage caused by something called phorbol ester (TPA). They even worked better than dexamethasone, which is a synthetic drug that fights inflammation. When you put baicalin into these special vesicles, it becomes even better for skin cells. These tiny bubbles could be a great way to deliver baicalin for treating skin inflammation, making it a useful tool for skincare and skin health.[R]

Where to Buy Baicalin (Skullcap Extract) Online

At PureRawz, your number one source for buying high-quality baikal skullcap online, we have Baicalin (Skullcap Extract) sold in capsules and powder form at an affordable price.

In order to produce quality items, we provide reference materials with every product we sell. Each of our products undergoes an independent, lab-tested Certificate of Analysis that provides consistency for standardized identification, purity, and concentration.

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Baicalin (chinese skullcap), derived from the Scutellaria baicalensis Georgi plant, is a natural compound with a rich history of medicinal use. It has a wide range of potential health benefits, including antiviral properties, protection against oxidative damage, inhibition of tumor growth, and reducing inflammation. Baicalin has shown promise in modulating the immune response and addressing inflammation in cerebrovascular and neurological disorders.

In research, Baicalin has displayed potential in various health areas. It has shown promise in protecting against neurodegenerative diseases like Parkinson’s by reducing oxidative stress and enhancing antioxidant activity. Additionally, Baicalin exhibits anti-inflammatory and anti-cancer properties, particularly in prostate and lung cancer, by inhibiting tumor growth and promoting apoptosis. It also holds the potential to address myocardial depression associated with sepsis and atherosclerosis by reducing inflammation and improving cardiovascular function.

Studies have explored Baicalin’s effectiveness in test subjects with both coronary artery disease and rheumatoid arthritis, showing favorable changes in blood lipid levels and inflammation markers. It has also demonstrated promise in alleviating depressive-like behaviors induced by chronic stress and might have a calming effect similar to anxiety-relief medications. For skin health, Baicalin-loaded nanovesicles have strong anti-inflammatory effects, making them useful for skin care and treating skin inflammation. Overall, Baicalin holds promise in various therapeutic applications, but further research and clinical studies are needed to confirm its effectiveness and safety in human subjects.


This information is for educational purposes only and does not constitute medical advice. THE PRODUCTS DESCRIBED HEREIN ARE FOR LABORATORY AND RESEARCH USE ONLY. Not as a dietary supplement listing. All clinical research must be conducted with oversight from the appropriate Institutional Review Board (IRB). All preclinical research must be conducted with oversight from the appropriate Institutional Animal Care and Use Committee (IACUC) following the guidelines of the Animal Welfare Act (AWA).

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